Environmental Agents in Lung and Pleural Neoplasms

  • Steven R. Blumen
  • Brooke T. Mossman
Part of the Molecular Pathology Library book series (MPLB, volume 1)


A number of chemical and other environmental pollutants, including noxious gases and metals, infectious agents, insoluble agents such as asbestos and wood dusts, and dietary factors, induce or promote lung cancers. Many of these agents are classified as “known” or “reasonably anticipated” carcinogens, including polycyclic aromatic hydrocarbons, metals such as cadmium, hexavalent chromium, and nickel compounds, and mineral fibers such as asbestos and erionite.1 Others are “suspect” carcinogens based on inconclusive data from epidemiologic, animal, and mechanistic studies. The use of mechanistic studies to predict carcinogenicity of environmental and occupational agents in humans has been advocated recently as a critical component of risk analysis.2 With the evolution and vast potential of new technologies such as microarray analysis and proteomics, our knowledge of the mechanisms of lung carcinogenesis has increased.


Polycyclic Aromatic Hydrocarbon Mesothelial Cell Malignant Mesothelioma Mesothelioma Cell Chrysotile Asbestos 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Steven R. Blumen
    • 1
  • Brooke T. Mossman
    • 1
  1. 1.Department of PathologyUniversity of VermontBurlingtonUSA

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