Response to Conventional Therapy and Targeted Molecular Therapy

  • Timothy Craig Allen
  • Anna Sienko
  • Philip T. Cagle
Part of the Molecular Pathology Library book series (MPLB, volume 1)


Currently, the standard chemotherapy regimen for non-small cell lung cancer (NSCLC) involves platinum-based anticancer drugs such as cisplatin, which functions by the formation of bulky platinum DNA adducts, along with a third-generation agent such as paclitaxel, gemcitabine, vinorelbine, or irinotecan.1, 2, 3, 4 Nonplatinum agents such as docetaxel, a taxane that functions by disrupting microtubule dynamics via β-tubulin binding, are also frequently used to treat NSCLC patients.4,5 Vinorelbine, a vinca alkaloid, have also been used with some success in treating NSCLC patients.1 The benefits of these standard systemic chemotherapeutic agents is limited for patients with advanced NSCLC, with half of those patients exhibiting an 8- to 11-month median survival despite cisplatinbased therapy.2,6 Along with troubling cisplatin toxicity, the development of cisplatin resistance has become a serious concern.1,3


Epidermal Growth Factor Receptor Clin Oncol Epidermal Growth Factor Receptor Mutation KRAS Mutation Epidermal Growth Factor Receptor Inhibitor 
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Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Timothy Craig Allen
    • 1
  • Anna Sienko
    • 2
  • Philip T. Cagle
    • 3
    • 4
  1. 1.Department of PathologyUniversity of Texas Health Center at TylerTylerUSA
  2. 2.Department of PathologyMethodist HospitalHoustonUSA
  3. 3.Pathology and Laboratory MedicineWeill Medical College of Cornell UniversityNew York
  4. 4.The Methodist HospitalHoustonUSA

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