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Pulmonary Angiogenesis in Neoplastic and Nonneoplastic Disorders

  • Michael P. Keane
  • Robert M. Strieter
Part of the Molecular Pathology Library book series (MPLB, volume 1)

Abstract

Angiogenesis is the process of new blood vessel growth and is a critical biologic process in both physiologic and pathologic conditions. Angiogenesis can occur in physiologic conditions, including normal wound repair and embryogenesis. In contrast, pathologic angiogenesis is associated with chronic inflammatory and fibroproliferative disorders, as well as growth of tumors. A variety of factors have been described that either promote or inhibit angiogenesis, including the CXC chemokines, endothelin-1 (ET-1), vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF). In the local microenvironment, net angiogenesis is determined by the balance between angiogenic and angiostatic factors.

Keywords

Vascular Endothelial Growth Factor Aberrant Angiogenesis Angiostatic Activity Pulmonary Angiogenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Michael P. Keane
    • 1
  • Robert M. Strieter
    • 2
  1. 1.Department of Pulmonary and Critical Care MedicineDavid Geffen School of Medicine at UCLALos AngelesUSA
  2. 2.Department of MedicineUniversity of Virginia School of MedicineCharlottesvilleUSA

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