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Tissue Culture Models

  • Roger A. Vertrees
  • Thomas Goodwin
  • Jeffrey M. Jordan
  • Joseph B. Zwischenberger
Part of the Molecular Pathology Library book series (MPLB, volume 1)

Abstract

The use of tissue cultures as a research tool to investigate the pathophysiologic bases of diseases has become essential in the current age of molecular biomedical research. Although it will always be necessary to translate and validate the observations seen in vitro to the patient or animal, the ability to investigate the role(s) of individual variables free from confounders is paramount toward increasing our understanding of the physiology of the lung and the role of its cellular components in disease. Additionally, it is not feasible to conduct certain research in humans because of ethical constraints, yet investigators may still be interested in the physiologic response in human tissues; in vitro characterization of human tissue is an acceptable choice.

Keywords

Airway Smooth Muscle Lung Cancer Cell Line Small Cell Lung Carcinoma Airway Smooth Muscle Cell Severe Acute Respiratory Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Roger A. Vertrees
    • 1
  • Thomas Goodwin
    • 2
  • Jeffrey M. Jordan
    • 3
  • Joseph B. Zwischenberger
    • 1
  1. 1.Department of SurgeryUniversity of Texas Medical BranchGalvestonUSA
  2. 2.Department of Biomedical Research and Operations BranchNASA/Johnson Space CenterHoustonUSA
  3. 3.Department of PathologyUniversity of Texas Medical BranchGalvestonUSA

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