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Nuclear Receptors in the Control of Lipid Metabolism

  • Shannon M. Reilly
  • Chih-Hao Lee

Nuclear hormone receptors are found at the heart of virtually every biological process. In addition to their functions in mediating steroid hormone effects, the role of this superfamily in maintaining metabolic homeostasis has been illuminated by the identification of dietary fats and their metabolites as ligands for several subfamilies. These receptors, in response to derivatives of fatty acids, cholesterol, and bile acids, constitute a transcriptional network controlling glucose and lipid metabolism as well as inflammation, all of which are key determinants of metabolic diseases, including dyslipidemia, insulin resistance, and atherosclerosis. In line with this, synthetic, high-affinity ligands developed to target these receptors have either been used or shown promise in the treatment of metabolic syndrome. For instance, the thiazolidinedione (TZD) class of drugs, one of the leading drug treatments of diabetes, specifically targets PPARgamma. This chapter discusses the metabolic roles and potential therapeutic applications of nuclear receptors, with an emphasis on receptors that sense and are activated by dietary lipids.

Keywords

Bile Acid Nuclear Receptor Cholesterol Efflux Nuclear Hormone Receptor Constitutive Androstane Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Shannon M. Reilly
    • 1
  • Chih-Hao Lee
    • 1
  1. 1.Department of Genetics and Complex DiseasesHarvard University School of Public HealthBostonUSA

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