Fertility Preservation and Adolescent Cancer Patients: Lessons from Adult Survivors of Childhood Cancer and Their Parents

  • Carrie L. Nieman
  • Karen E. Kinahan
  • Susan E. Yount
  • Sarah K. Rosenbloom
  • Kathleen J. Yost
  • Elizabeth A. Hahn
  • Timothy Volpe
  • Kimberley J. Dilley
  • Laurie Zoloth
  • Teresa K. Woodruff
Part of the Cancer Treatment and Research book series (CTAR, volume 138)

Building on 40 years of progress in cancer detection and treatment, survival rates for childhood cancers have risen from 20 % to almost 80 % [1,2]. Approximately 270,000 Americans are childhood cancer survivors and, by 2010, an estimated 1 in every 250 adults will be living with a history of childhood cancer [2,3]. The early and late effects of treatment are beginning to take on greater importance for survivors, their families and providers [4]. Increasing numbers of childhood cancer survivors are beginning to face a new challenge in returning to normalcy after cancer.


Focus Group Ovarian Tissue Childhood Cancer Fertility Preservation Pediatric Cancer Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bleyer WA. The U.S. pediatric cancer clinical trials programmes: international implications and the way forward. Eur J Cancer 1997;33:1439–1447.CrossRefPubMedGoogle Scholar
  2. 2.
    Reis LAG, Eisner MP, Kosary CL, et al, editors. SEER cancer statistics review, 1973–1999. Bethesda, MD: National Cancer Institute, 2002.Google Scholar
  3. 3.
    Bleyer WA. The impact of childhood cancer on the United States and the world. Cancer 1990;40:355–367.Google Scholar
  4. 4.
    Eiser C. Practitioner review: long-term consequences of childhood cancer. J Child Psychol Psychiatry 1998;39:621–633.CrossRefPubMedGoogle Scholar
  5. 5.
    Stevens MCG, Mahler H, Parkes S. The health status of adult survivors of cancer in childhood. Eur J Cancer 1998;34:694–698.CrossRefPubMedGoogle Scholar
  6. 6.
    Zeltzer LK. Cancer in adolescents and young adults: psychosocial aspects in long-term survivors. Cancer 1993;71:3463–3468.CrossRefPubMedGoogle Scholar
  7. 7.
    Robertson JA. Cancer and fertility: ethical and legal challenges. J Natl Cancer Inst Monogr 2005;34:104–106.CrossRefPubMedGoogle Scholar
  8. 8.
    Patrizio P, Butts S, Caplan A. Ovarian tissue preservation and future fertility: emerging technologies and ethical considerations. J Natl Cancer Inst Monogr 2005;34:107–110.CrossRefPubMedGoogle Scholar
  9. 9.
    Crockin SL. Legal issues related to parenthood after cancer. J Natl Cancer Inst Monogr 2005;34:111–113.CrossRefPubMedGoogle Scholar
  10. 10.
    Nieman CL, Kazer R, Brannigan RE, et al. Cancer survivors and infertility: a review of a new problem and novel answers. J Support Oncol 2006;4:171–178.PubMedGoogle Scholar
  11. 11.
    Hammer-Burns L. An overview of the psychology of infertility: comprehensive psychosocial history of infertility. Infert Reprod Med Clinic N Am 1993;4:433–454.Google Scholar
  12. 12.
    Schover L. Psychosocial aspects of infertility and decisions about reproduction in young cancer survivors: a review. Med Pediat Oncol 1999;33:53–59.CrossRefGoogle Scholar
  13. 13.
    Ostroff J, Steinglass P. Psychosocial adaptation following treatment: a family systems perspective on childhood cancer survivorship. In: Baider L, Cooper CL, Kaplan De-Nour A, editors. Cancer and the family. Chichester, England: John Wiley & Sons, Inc., 1996:129–148.Google Scholar
  14. 14.
    Zebrack BJ, Casillas J, Nohr L, et al. Fertility issues for young adult survivors of childhood cancer. Psycho-oncology 2004;13:689–699.CrossRefPubMedGoogle Scholar
  15. 15.
    Schover L. Motivation for parenthood after cancer: a review. J Natl Cancer Inst Monogr 2005;34:2–5.CrossRefPubMedGoogle Scholar
  16. 16.
    Schover LR, Rybicki LA, Martin BA, et al. Having children after cancer: a pilot survey of survivors’ attitudes and experiences. Cancer 1999;86:697–709.CrossRefPubMedGoogle Scholar
  17. 17.
    Schover LR. Sexuality and fertility after cancer. New York: John Wiley & Sons, Inc., 1997.Google Scholar
  18. 18.
    Dow KH. Having children after breast cancer. Cancer Pract 1994;2:407–413.PubMedGoogle Scholar
  19. 19.
    Tournaye H, Goossens E, Verheyen G, et al. Preserving the reproductive potential of men and boys with cancer: current concepts and future prospects. Hum Reprod Update 2004;10:525–532.CrossRefPubMedGoogle Scholar
  20. 20.
    Meirow D, Nugent D. The effects of radiotherapy and chemotherapy on female reproduction. Hum Reprod Update 2001;7:535–543.CrossRefPubMedGoogle Scholar
  21. 21.
    Sonmezer M, Oktay K. Fertility preservation in female patients. Hum Reprod Update 2004;10:251–266.CrossRefPubMedGoogle Scholar
  22. 22.
    Wallace WHB, Anderson RA, Irvine DS. Fertility preservation for young patients with cancer: who is at risk and what can be offered? Lancet Oncol 2005;6:209–218.CrossRefPubMedGoogle Scholar
  23. 23.
    Kim SS, Battaglia DE, Soules MR. The future of human ovarian cryopreservation and transplantation: fertility and beyond. Fertil Steril 2001;75:1049–1056.CrossRefPubMedGoogle Scholar
  24. 24.
    Oktay K, Buyuk E, Veeck L, et al. Embryo development after heterotopic transplantation of cryopreserved ovarian tissue. Lancet 2004;363:837–840.CrossRefPubMedGoogle Scholar
  25. 25.
    Donnez J, Dolmans MM, Demylle D, et al. Livebirth after orthotopic transplantation of cryopreserved ovarian tissue. Lancet 2004;364:1405–1410.CrossRefPubMedGoogle Scholar
  26. 26.
    Xu M, Kreeger PK, Shea LD, et al. Tissue engineered follicles produce live, fertile offspring. Tissue Eng 2006;12:2739–2746.CrossRefPubMedGoogle Scholar
  27. 27.
    Burns KC, Boudreau C, Panepinto JA. Attitudes regarding fertility preservation in female adolescent cancer patients. J Pediatr Hematol Oncol 2006;28:350–354.CrossRefPubMedGoogle Scholar
  28. 28.
    Kodish ED, Pentz RD, Noll RB, et al. Informed consent in the Childrens Cancer Group: results of preliminary research. Cancer 1998;82:2467–2481.CrossRefPubMedGoogle Scholar
  29. 29.
    Somerfield MR, Curbow B, Wingard JR, et al. Coping with the physical and psychosocial sequelae of bone marrow transplantation among long-term survivors. J Behav Med 1996;19:163–184.CrossRefPubMedGoogle Scholar
  30. 30.
    Goodwin T, Oosterhuis BE, Kiernan M, et al. Attitudes and practices of pediatric oncology providers regarding fertility issues. Pediatr Blood Cancer 2006; [Epub ahead of print].Google Scholar
  31. 31.
    Hinds PS, Oakes L, Quargnenti A, et al. An international feasibility study of parental decision making in pediatric oncology. Oncol Nurs Forum 2000;27:1233–1243.PubMedGoogle Scholar
  32. 32.
    Kelly KP, Porock D. A survey of pediatric oncology nurses’ perceptions of parent educational needs. J Pediatr Oncol Nurs 2005;22:58–66.CrossRefPubMedGoogle Scholar
  33. 33.
    Pyke-Grimm KA, Degner L, Small A, et al. Preferences for participation in treatment decision making and information needs of parents of children with cancer: a pilot study. J Pediatr Oncol Nurs 1999;16:13–24.CrossRefPubMedGoogle Scholar
  34. 34.
    Clarke-Steffen L. Waiting and not knowing: the diagnosis of cancer in a child. J Pediatr Oncol Nurs 1993;10:146–153.CrossRefPubMedGoogle Scholar
  35. 35.
    Fife B, Norton J, Groom G. The family’s adaptation to childhood leukemia. Soc Sci Med 1987;24:159–168.CrossRefPubMedGoogle Scholar
  36. 36.
    Sawyer M, Antoniou G, Toogood I, et al. Childhood cancer: a two-year prospective study of the psychological adjustment of children and parents. J Am Acad Child Adoles Psychiatry 1997;36:1736–1743.CrossRefGoogle Scholar
  37. 37.
    Hoekstra-Weebers JEHM, Jaspers JPC, Kamps WA, et al. Gender differences in psychological adaptation and coping in parents of pediatric cancer patients. Psycho-oncology 1998;7:26–36.CrossRefPubMedGoogle Scholar
  38. 38.
    Kazak AE, Boeving CA, Alderfer MA, et al. Posttraumatic stress symptoms during treatment in parents of children with cancer. J Clin Oncol 2005;23:7405–7410.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Carrie L. Nieman
    • 1
  • Karen E. Kinahan
    • 2
  • Susan E. Yount
    • 2
  • Sarah K. Rosenbloom
    • 2
  • Kathleen J. Yost
    • 2
  • Elizabeth A. Hahn
    • 2
  • Timothy Volpe
    • 2
  • Kimberley J. Dilley
    • 2
  • Laurie Zoloth
    • 2
  • Teresa K. Woodruff
    • 3
  1. 1.University of IllinoisChicagoUSA
  2. 2.Northwestern UniversityChicagoUSA
  3. 3.Institute for Women's Health Research, Feinberg School of MedicineNorthwestern UniversityChicagoUSA

Personalised recommendations