Skip to main content
SpringerLink
Log in

A Brief History of Research on Agrobacterium Tumefaciens: 1900–1980s

  • Chapter
Agrobacterium: From Biology to Biotechnology

The study of tumorigenesis on plants as a result of their infection by Agrobacterium tumefaciens has resulted in enormous advances in our understanding of interspecies genetic transfer. This chapter seeks to trace the earlier studies (from the early 1900s up to mid 1980s) that were involved in defining the biology, genetics and molecular biology of this system. The analysis of these studies will be carried out with the objective of unders-tanding how Agrobacterium has become not only a model system in bacterial pathogenesis but also a key player in both basic plant molecular genetics and agricultural biotechnology.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

6 References

  • Akiyoshi DE, Klee H, Amasino RM, Nester EW, Gordon MP (1984) T-DNA of Agrobacterium tumefaciens encodes an enzyme of cytokinin biosynthesis. Proc Natl Acad Sci USA 81: 5994-5998

    PubMed  Google Scholar 

  • Alonso JM, Stepanova AN (2003) T-DNA mutagenesis in Arabidopsis. Methods Mol Biol 236: 177-188

    PubMed  Google Scholar 

  • Barker R, Idler KB, Thompson DV, Kemp JD (1983) Nucleotide sequence of the T-DNA region from the Agrobacterium tumefaciens octopine Ti plasmid pTi 15955. Plant Mol Biol 2: 335-350

    Google Scholar 

  • Baron C, Zambryski PC (1995) The plant response in pathogenesis, symbiosis and wounding: variations on a common theme? Annu Rev Genet 29: 107-129

    PubMed  Google Scholar 

  • Barry GF, Rogers SG, Fraley RT, Brand L (1984) Identification of cloned cyto-kinin biosynthesis gene. Proc Natl Acad Sci USA 81: 4776-4780

    PubMed  Google Scholar 

  • Barton KA, Binns AN, Matzke AJM, Chilton MD (1983) Regeneration of intact tobacco plants containing full length copies of genetically engineered T-DNA, and transmission of T-DNA to R1 progeny. Cell 32: 1033-1043

    PubMed  Google Scholar 

  • Bevan MW, Flavell RB, Chilton M-D (1983) A chimeric antibiotic resistance gene as a selectable marker for plant transformation. Nature 304: 184-187

    Google Scholar 

  • Binns AN (1983) Host and T-DNA encoded determinants of cytokinin autonomy in tobacco cells transformed by Agrobacterium tumefaciens. Planta 158: 272-279

    Google Scholar 

  • Binns AN, Sciaky D, Wood HN (1982) Variation in hormone autonomy and regeneration potential of cells transformed by strain A66 of Agrobacterium tumefaciens. Cell 31: 605-612

    PubMed  Google Scholar 

  • Binns AN, Wood HN, Braun AC (1981) Suppression of the tumourous state in tobacco crown gall teratomas: A clonal analysis. Differentiation 19: 97-102

    Google Scholar 

  • Bomhoff G, Klapwijk PM, Kester HCM, Schilperoort RA, Hernalsteens JP, Schell J (1976) Octopine and nopaline synthesis and breakdown genetically con-trolled by a plasmid of Agrobacterium tumefaciens. Mol Gen Genet 145: 177-181

    PubMed  Google Scholar 

  • Braun AC (1943) Studies on tumor inception in the crown-gall disease. Am J Bot 30: 674-677

    Google Scholar 

  • Braun AC (1947) Thermal studies on tumor inception in the crown gall disease. Am J Bot 34: 234-240

    Google Scholar 

  • Braun AC (1948) Studies on the origin and development of plant teratomas incited by the crown-gall bacterium. Am J Bot 35: 511-519

    Google Scholar 

  • Braun AC (1951a) Cellular autonomy in crown gall. Phytopathology 41: 963-966 Braun AC (1951b) Recovery of crown gall tumor cells. Cancer Res 11: 839-844

    PubMed  Google Scholar 

  • Braun AC (1952) Conditioning of the host cell as a factor in the transformation process in crown gall. Growth 16: 65-74

    PubMed  Google Scholar 

  • Braun AC (1958) A physiological basis for the autonomous growth of the crown gall tumor cell. Proc Natl Acad Sci USA 44: 344-349

    PubMed  Google Scholar 

  • Braun AC (1959) A demonstration of the recovery of the crown-gall tumor cell with the use of complex tumors of single cell origin. Proc Natl Acad Sci USA 45: 932-938

    PubMed  Google Scholar 

  • Braun AC (1981) An epigenetic model for the origin of cancer. Q Rev Biol 56: 33-60

    PubMed  Google Scholar 

  • Braun AC (1982) A history of the crown gall problem. In G Kahl, J Schell, eds, Molecular Biology of Plant Tumors. Academic Press, New York, pp 155-210

    Google Scholar 

  • Braun AC, Laskaris T (1942) Tumor formation by attenuated crown-gall bacteria in the presence of growth promoting substances. Proc Natl Acad Sci USA 28: 468-477

    PubMed  Google Scholar 

  • Braun AC, Mandle RJ (1948) Studies on the inactivation of the tumor inducing principle in crown gall. Growth 12: 255-269

    PubMed  Google Scholar 

  • Braun AC, White PR (1943) Bacteriological sterility of tissues derived from sec-ondary crown-gall tumors. Phytopathology 33: 85-100

    Google Scholar 

  • Braun AC, Wood HN (1976) Suppression of the neoplastic state with the ac-quistion of specialized functions in cells, tissues and organs of crown-gall teratomas of tobacco. Proc Natl Acad Sci USA 73: 496-500

    PubMed  Google Scholar 

  • Brencic A, Angert ER, Winans SC (2005) Unwounded plants elicit Agrobacterium vir gene induction and T-DNA transfer: transformed plant cells produce opines yet are tumor free. Mol Microbiol 57: 1522-1531

    PubMed  Google Scholar 

  • Buchmann I, Marner F-J, Schröder G, Waffenschmidt S, Schröder J (1985) Tumor genes in plants: T-DNA encoded cytokinin biosynthesis. EMBO J 4: 853-859

    PubMed  Google Scholar 

  • Cavara F (1897) Intorno alla eziologia di alcune malattie di plant cultivate. Stn Sper Agrar Ital Modena 30: 483-487

    Google Scholar 

  • Chilton M-D, Drummond MH, Merio DJ, Sciaky D, Montoya AL, Gordon MP, Nester EW (1977) Stable incorporation of plasmid DNA into higher plant cells: the molecular basis of crown gall tumorigenesis. Cell 11: 263-271

    PubMed  Google Scholar 

  • Chilton M-D, Drummond MH, Merlo DJ, Sciaky D (1978) Highly conserved DNA of Ti plasmid overlaps T-DNA maintained in plant tumors. Nature 275: 147-149

    Google Scholar 

  • Chilton M-D, Farrand SK, Eden FC, Currier TC, Bendich AJ, Gordon MP, Nester EW (1974) Is there foreign DNA in crown gall tumor DNA? In R Markham, DR Davies, D Hopwood, RW Horne, eds, Modification of the Information Content of Plant Cells. Elsevier, New York, p 297

    Google Scholar 

  • Chilton M-D, Saiki RK, Yadav N, Gordon MP, Quétier F (1980) T-DNA from Agrobacterium Ti plasmid is in the nuclear fraction of crown gall tumor cells. Proc Natl Acad Sci USA 77: 2693-2697

    PubMed  Google Scholar 

  • De Greve H, Leemans J, Hernalsteens JP, Thia-Toong L, De Beukeleer M, Willmitzer L, Otten L, Van Montagu M, Schell J (1982) Regeneration of normal and fertile plants that express octopine synthase from tobacco galls af-ter deletion of tumor-controlling functions. Nature 300: 752-757

    Google Scholar 

  • Depicker A, Van Montagu M, Schell J (1978) Homologous DNA sequences in different Ti-plasmids are essential for oncogenicity. Nature 275: 150-153

    Google Scholar 

  • Dons JJM (1975) Crown gall - a plant tumor. Investigation on the nuclear content and on the presnce of Agrobacterium tumefaciens DNA and phage PS8 DNA in crown gall tumor cells. Ph. D. dissertation. Leiden, The Netherlands

    Google Scholar 

  • Douglas CJ, Halperin W, Nester EW (1982) Agrobacterium tumefaciens mutants affected in attachment to plant cell. J Bacteriol 152: 1265-1275

    PubMed  Google Scholar 

  • Drlica KA, Kado CI (1975) Crown gall tumors: are bacterial nucleic acids in-volved? Bacteriol Rev 39: 186-196

    PubMed  Google Scholar 

  • Farrand SK, Van Berkum PB, Oger P (2003) Agrobacterium is a definable genus of the family Rhizobiaceae. Int J Syst Evol Microbiol 53: 1681-1687

    PubMed  Google Scholar 

  • Fraley RT, Rogers SG, Horsch RB, Sanders PR, Flick JS, Adams SP, Bittner ML, Brand LA, Fink CL, Fry JS, Galluppi GR, Goldberg SB, Hoffmann NL, Woo SC (1983) Expression of bacterial genes in plant cells. Proc Natl Acad Sci USA 80: 4803-4807

    PubMed  Google Scholar 

  • Garfinkel DJ, Nester EW (1980) Agrobacterium tumefaciens mutants affected in crown gall tumorigenesis and octopine catabolism. J Bacteriol 144: 732-743

    PubMed  Google Scholar 

  • Garfinkel DJ, Simpson RB, Ream LW, White FF, Gordon MP, Nester EW (1981) Genetic analysis of crown gall: fine structure map of the T-DNA by sitedirected mutagenesis. Cell 27: 143-153

    PubMed  Google Scholar 

  • Goldmann A, Tempé J, Morel G (1968) Quelques particularités de diverses sou-ches d’Agrobacterium tumefaciens. CR Seances Soc Biol Ses Fil 162: 630-631

    Google Scholar 

  • Hamilton RC, Fall MZ (1971) The loss of tumor initiating ability in Agrobacte-rium tumefaciens by incubation at high temperature. Experientia 27: 229-230

    PubMed  Google Scholar 

  • Hendrickson AA, Baldwin IL, Riker AJ (1934) Studies on certain physiological characters of Phytomonas tumefaciens, Phytomonas rhizogenes and Phytomonas radiobacter. J Bacteriol 28: 597-618

    PubMed  Google Scholar 

  • Herrera-Estrella L, Depicker A, Van Montagu M, Schell J (1983) Expression of chimaeric genes transferred into plant cells using a Ti plasmid derived vector. Nature 303: 209-213

    Google Scholar 

  • Hille J, Wullems GJ, Schilperoort RA (1983) Non-oncogenic T-region mutants of Agrobacterium tumefaciens do transfer T-DNA into plant cells. Plant Mol Biol 2: 155-164

    Google Scholar 

  • Hoekma A, Hirsch PR, Hooykaas PJJ, Schilperoort RA (1983) A binary vector strategy based on separation of the vir and T-region of the Agroabcterium tumefaciens Ti plasmid. Nature 303: 179-180

    Google Scholar 

  • Horsch RB, Fraley RT, Rogers SG, Sanders PR, Lloyd A, Hoffmann N (1984) In-heritance of functional foreign genes in plants. Science 223: 496-497

    PubMed  Google Scholar 

  • Inzé D, Follin A, Van Lijsebettens M, Simoens C, Genetello C, et al. (1984) Ge-netic analysis of the individual T-DNA genes of Agrobacterium tumefaciens: further evidence that two genes are involved in indole-3-acetic acid sysnthe-sis. Mol Gen Genet 194: 265-274

    Google Scholar 

  • Kahl G, Schell J (1982) Molecular Biology of Plant Tumors. Academic Press, New York

    Google Scholar 

  • Kerr A (1969) Transfer of virulence between isolates of Agrobacterium. Nature 223: 1175-1176

    Google Scholar 

  • Klee HJ, White FF, Iyer VN, Gordon MP, Nester EW (1983) Mutational analysis of the virulence region of an Agrobacterium tumefaciens Ti plasmid. J Bacte-riol 153: 878-883

    Google Scholar 

  • Kunkel LO (1941) Heat cure of aster yellows in periwinkle. Am J Bot 28: 761-769

    Google Scholar 

  • Leemans J, Deblaere R, Willmitzer L, De Greeve H, Hernalsteens JP, Van Montagu M, Schell J (1982) Genetic identification of functions of TL-DNA transcripts in octopine crown galls. EMBO J 1: 147-152

    PubMed  Google Scholar 

  • Lejeune B, Jubier MF (1967) Etude de la dégradation de la lysopine par Agrobacterium tumefaciens. C R Hebd Seances Acad Sci Ser D 264: 1803-1805

    Google Scholar 

  • Lemmers M, De Beuckeleer M, Holsters M, Zambryski P, Depicker A, Hernals-teens JP, Van Montagu M, Schell J (1980) Internal organization, boundaries and integration of Ti-plasmid DNA in nopaline crown gall tumours. J Mol Biol 144: 353-376

    PubMed  Google Scholar 

  • Levin I, Levine M (1918) Malignancy of the crown gall and its analogy to animal cancer. Proc Soc Exp Biol and Med 16: 21-22

    Google Scholar 

  • Levine M (1919) Studies on plant cancers - I. The mechanism of the formation of the leafy crown gall. Bull Torr Bot Soc 46: 447-452

    Google Scholar 

  • Lioret C (1957) Les acides aminés libres des tissus de crown-gall. Mise en évi-dence d’un acide aminé particulier à ces tissus. CR Hebd Seances Acad Sci 244: 2171-2174

    Google Scholar 

  • Lippincott BB, Lippincott JA (1969) Bacterial attachment to a specific wound site as an essential stage in tumor initiation by Agrobacterium tumefaciens. J Bac-teriol 97: 620-628

    Google Scholar 

  • Lippincott BB, Whatley MH, Lippincott JA (1977) Tumor induction by Agrbabcterium tumefaciens involves attachment of the bacterium to a site on the host plant cell wall. Plant Physiol 59: 388-390

    PubMed  Google Scholar 

  • Lippincott JA, Lippincott BB (1978) Cell walls of crown-gall tumors and embry-onic tissues lack Agrobacterium adherence sites. Science 109: 1075-1078

    Google Scholar 

  • Locke SB, Riker AJ, Duggar BM (1938) Growth substance and the development of crown gall. J Agr Res 57: 21-39

    Google Scholar 

  • McCullen CA, Binns AN (2006) Agrobacterium tumefaciens and plant cell inter-actions and activities required for interkingdom macromolecular transfer. Annu Rev Cell Dev Biol 22: 101-127

    PubMed  Google Scholar 

  • Meins FJ, Binns AN (1978) Epigenetic clonal variation in the requirement of plant cells for cytokinins. In S Subtelny, IM Sussex, eds, The Clonal Basis of De-velopment. Academic Press, New York, pp 185-201

    Google Scholar 

  • Moore L, Warren G, Strobel G (1979) Involvement of a plasmid in the hairy root disease of plants caused by Agrobacterium rhizogenes. Plasmid 2: 617-626

    PubMed  Google Scholar 

  • Neff NT, Binns AN (1985) Agrobacterium tumefaciens interaction with suspen-sion-cultured tomato cells. Plant Physiol 77: 35-42

    PubMed  Google Scholar 

  • Ooms G, Hooykaas PJJ, Noleman G, Schilperoort RA (1981) Crown gall tumors of abnormal morphology induced by Agrobacterium tumefaciens carrying mu-tated octopine Ti plasmids: analysis of T-DNA functions. Gene 14: 33-50

    PubMed  Google Scholar 

  • Ooms G, Klapwijk PM, Poulis JA, Schilperoort RA (1980) Characterization of Tn904 insertions in octopine Ti plasmid mutants of Agrobacterium tumefa-ciens. J Bacteriol 144: 82-91

    PubMed  Google Scholar 

  • Petit A, Delhaye S, Tempé J, Morel G (1970) Recherches sur les guanidines des tissus de crown-gall. Mise en evidence d’une relation biochimique spécifique entre les souches d’Agrobacterium tumefaciens et les tumeurs qu’elles indui-sent. Physiol Veg 8: 205-213

    Google Scholar 

  • Petit A, Tourneur J (1972) Perte de virulence associée à la perte d’une activité en-zymatique chez Agrobacterium tumefaciens. C R Acad Sci Paris Life Sciences 275: 137-139

    Google Scholar 

  • Ream LW, Gordon MP, Nester EW (1983) Multiple mutations in the T region of the Agrobacterium tumefaciens tumor-inducing plasmid. Proc Natl Acad Sci USA 80: 1660-1664

    PubMed  Google Scholar 

  • Riker AJ (1923a) Some morphological resoponses of the host tissue to the crown gall organism. J Agric Res 26: 425-435

    Google Scholar 

  • Riker AJ (1923b) Some relations of the crown gall organism to its host tissue. J Agric Res 25: 119-132

    Google Scholar 

  • Riker AJ (1926) Studies on the influence of some environmental factors on the development of crown gall. J Agric Res 32: 83-96

    Google Scholar 

  • Schröder G, Waffenschmidt S, Weiler EW, Schröder J (1984) The T-region of Ti plasmids codes for an enzyme synthesizing indole-3-acetic acid. Eur J Bio-chem 138: 387-391

    Google Scholar 

  • Skoog F, Miller CO (1957) Chemical regulation of growth and organ formation in plant tissues cultured in vitro. Symp Soc Exp Biol 11: 118-131

    Google Scholar 

  • Smith EF (1916) Crown gall studies showing changes in plant structures due to a changed stimula. Jour Agric Res 6: 179-182 (plus plates)

    Google Scholar 

  • Smith EF, Brown NA, Townsend CO (1912) The structure and development of crown gall: A plant cancer. US Dept Agric Bur Plant Ind Bull 255: 1-61

    Google Scholar 

  • Smith EF, Townsend CO (1907) A plant tumor of bacterial origin. Science 25: 671-673

    PubMed  Google Scholar 

  • Stachel SE, Messens E, Van Montagu M, Zambryski P (1985) Identification of the signal molecules produced by wounded plant cell that activate T-DNA trans-fer in Agrobacterium tumefaciens. Nature 318: 624-629

    Google Scholar 

  • Stachel SE, Nester EW (1986) The genetic and transcriptional organization of the vir region of the A6 Ti plasmid of Agrobacterium tumefaciens. EMBO J 5: 1445-1454

    PubMed  Google Scholar 

  • Stachel SE, Timmerman B, Zambryski P (1986) Generation of single-stranded T-DNA molecules during the initial stages of T-DNA transfer for Agrobacte-rium tumefaciens to plant cells. Nature 322: 706-712

    Google Scholar 

  • Stachel SE, Timmerman B, Zambryski P (1987) Activation of Agrobacterium tu-mefaciens vir gene expression generates multiple single-stranded T-strand molecules from the pTiA6 T-region: requirement for 5’ virD gene products. EMBO J 6: 857-863

    PubMed  Google Scholar 

  • Stachel SE, Zambryski PC (1986) virA and virG control the plant-induced activa-tion of the T-DNA transfer process of A. tumefaciens. Cell 46: 325-333

    PubMed  Google Scholar 

  • Tempé J, Goldmann A (1982) Occurence and biosynthesis of opines. In G Kahl, JS Schell, eds, Molecular Biology of Plant Tumors. Academic Press, New York, pp 427-449

    Google Scholar 

  • Thomashow LS, Reeves S, Thomashow MF (1984) Crown gall oncogenesis: evi-dence that a T-DNA gene from the Agrobacterium Ti plasmid pTiA6 encodes an enzyme that catalyzes synthesis of indole-3-acetic acid. Proc Natl Acad Sci USA 81: 5071-5075

    PubMed  Google Scholar 

  • Thomashow MF, Hughly S, Buchholz WG, Thomashow LS (1986) Molecular ba-sis for the auxin-independent phenotype of crown gall tumor tissue. Science 231: 616-618

    PubMed  Google Scholar 

  • Thomashow MF, Nutter R, Montoya AL, Gordon MP, Nester EW (1980a) Inte-gration and organization of Ti plasmid sequences in crown gall tumors. Cell 19: 729-739

    PubMed  Google Scholar 

  • Thomashow MF, Nutter R, Postle K, Chilton M-D, Blattner FR, Powell A, Gordon MP, Nester EW (1980b) Recombination between higher plant DNA and the Ti plasmid of Agrobacterium tumefaciens. Proc Natl Acad Sci USA 77: 6448-6452

    PubMed  Google Scholar 

  • Turgeon R, Wood HN, Braun AC (1976) Studies on the recovery of crown gall tumor cells. Proc Natl Acad Sci USA 73: 3562-3564

    PubMed  Google Scholar 

  • Van Larebeke N, Engler G, Holsters M, Van den Elsacker S, Zaenen I, Schilpero-ort RA, Schell J (1974) Large plasmid in Agrobacterium tumefaciens essential for crown gall-inducing ability. Nature 252: 169-170

    PubMed  Google Scholar 

  • Van Larebeke N, Genetello C, Schell J, Schilperoort RA, Hermans AK, Van Mon-tagu M, Hernalsteens JP (1975) Acquisition of tumour-inducing ability by non-oncogenic agrobacteria as a result of plasmid transfer. Nature 255: 742-743

    PubMed  Google Scholar 

  • Van Onckelen H, Prinsen E, Inzé D, Rudelsheim P, Van Lijsebettens M, Follin A, Schell J, Van Montagu M, De Greef J (1986) Agrobacterium T-DNA gene 1 codes for tryptophan 2-monooxygenase activity in tobacco crown gall cells. FEBS Lett 198: 357-360

    Google Scholar 

  • Van Onckelen H, Rudelsheim P, Hermans R, Horemans S, Messens E, Hernalsteens J-P, Van Montagu M, De Greef J (1984) Kinetics of endogenous cytokinin, IAA and ABA levels in relation to the growth and morphology of tobacco crown gall tissue. Plant Cell Physiol 25: 1017-1025

    Google Scholar 

  • Wang K, Herrera-Estrella L, Van Montagu M, Zambryski P (1984) Right 25 bp terminus sequence of the nopaline T-DNA is essential for and determines di-rection of DNA transfer from Agrobacterium to the plant genome. Cell 38: 455-462

    PubMed  Google Scholar 

  • Watson B, Currier TC, Gordon MP, Chilton M-D, Nester EW (1975) Plasmid re-quired for virulence of Agrobacterium tumefaciens. J Bacteriol 123: 255-264

    PubMed  Google Scholar 

  • White FF, Nester EW (1980) Hairy root: plasmid encodes virulence traits in Agrobacterium rhizogenes. J Bacteriol 141: 1134-1141

    PubMed  Google Scholar 

  • White PR, Braun AC (1941) Crown gall production by bacteria free tumor tissues. Science 94: 239-241

    PubMed  Google Scholar 

  • Willmitzer L, De Beuckeleer M, Lemmers M, Van Montagu M, Schell J (1980) DNA from Ti plasmid present in nucleus and absent from plastids of crown gall plant cells. Nature 287: 359-361

    Google Scholar 

  • Willmitzer L, Dhaese P, Schreier PH, Schmalenbach W, Van Montagu M, Schell J (1983) Size, location and polarity of T-DNA-encoded transcripts in nopaline crown gall tumos-common transcripts in octopine and nopaline tumors. Cell 32: 1045-1056

    PubMed  Google Scholar 

  • Willmitzer L, Simons G, Schell J (1982) The TL-DNA in octopine crown-gall tu-mors codes for seven well-defined polyadenylated transcripts. EMBO J 1: 139-146

    PubMed  Google Scholar 

  • Wood HN, Binns AN, Braun AC (1978) Differential expression of oncogenicity and nopaline synthesis in intact leaves derived from crown gall teratomas of tobacco. Differentiation 11: 175-180

    Google Scholar 

  • Yadav NS, Postle K, Saiki RK, Thomashow MF, Chilton M-D (1980) T-DNA of a crown gall teratoma is covalently joined to host plant DNA. Nature 287: 458-461

    Google Scholar 

  • Yadav NS, Vanderleyden J, Bennet DR, Barnes WM, Chilton M-D (1982) Short direct repeats flank th T-DNA on a nopaline Ti plasmid. Proc Natl Acad Sci USA 79: 6322-6326

    PubMed  Google Scholar 

  • Yang F, Montoya AL, Merlo DJ, Drummond MH, Chilton M-D, Nester EW, Gordon MP (1980) Foreign DNA sequences in crown gall teratomas and their fate during the loss of the tumorous traits. Mol Gen Genet 177: 707-714

    PubMed  Google Scholar 

  • Young JM, Kuykendall LD, Martinez-Romero E, Kerr A, Sawada H (2001) A revision of Rhizobium Frank 1889, with an emended description of the ge-nus, and the inclusion of all species of Agrobacterium Conn 1942 and Al-lorhizobium undicola de Lajudie et al. 1998 as new combinations: Rhizobium radiobacter, R. rhizogenes, R. rubi, R. undicola and R. vitis. Int J Syst Evol Microbiol 51: 89-103

    PubMed  Google Scholar 

  • Zaenen I, Van Larebeke N, Tenchy H, Van Montagu M, Schell J (1974) Super-coiled circular DNA in crown gall inducing Agrobacterium strains. J Mol Biol 86: 109-127

    PubMed  Google Scholar 

  • Zambryski P, Holsters M, Kruger K, Depicker A, Schell J, Van Montagu M, Goodman HM (1980) Tumor DNA structure in plant cells transformed by A. tumefaciens. Science 209: 1385-1391

    PubMed  Google Scholar 

  • Zambryski PC, Joos H, Genetello C, Leemans J, Van Montagu M, Schell J (1983) Ti plasmid vector for the introduction of DNA into plant cells without altera-tion of their normal regeneration capacity. EMBO J 2: 2143-2150

    PubMed  Google Scholar 

  • Zhu Y, Nam J, Humara JM, Mysore KS, Lee LY, Cao H, Valentine L, Li J, Kaiser AD, Kopecky AL, Hwang HH, Bhattacharjee S, Rao PK, Tzfira T, Rajagopal J, Yi H, Veena, Yadav BS, Crane YM, Lin K, Larcher Y, Gelvin MJ, Knue M, Ramos C, Zhao X, Davis SJ, Kim SI, Ranjith-Kumar CT, Choi YJ, Hallan VK, Chattopadhyay S, Sui X, Ziemienowicz A, Matthysse AG, Citovsky V, Hohn B, Gelvin SB (2003) Identification of Arabidopsis rat mutants. Plant Physiol 132: 494-505

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biology and Plant Sciences Institute, University of Pennsylvania, Philadelphia, PA 19104, USA

    Andrew N. Binns

Authors
  1. Andrew N. Binns
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Molecular, Cellular and Developmental Biology, University of Michigan, 830 N. University Ave. 4071D Natural Science Building, Ann Arbor, MI 48109-1048, USA

    Tzvi Tzfira

  2. Department of Biochemistry and Cell Biology, State University of New York, Stony Brook, NY 11792-5215, USA

    Vitaly Citovsky

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Binns, A.N. (2008). A Brief History of Research on Agrobacterium Tumefaciens: 1900–1980s. In: Tzfira, T., Citovsky, V. (eds) Agrobacterium: From Biology to Biotechnology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72290-0_2

Download citation

Publish with us

Policies and ethics

Search

Navigation