Cellular Mechanisms of Working Memory and its Modulation by Dopamine in the Prefrontal Cortex of Primates and Rats

  • Guillermo Gonzalez-Burgos
  • Sven Kröner
  • Jeremy K. Seamans

In this chapter we first present a simplified and abbreviated view of the complex organization of the PFC in rodents and primates with an emphasis on those properties that might represent the substrate of putative WM functions. We will then compare the primate dorsolateral and rat medial PFC modulation by dopaminergic afferents. Finally, we give an overview of the properties of PFC neurons in primate and rat PFC during WM tasks.


Prefrontal Cortex Pyramidal Neuron Pyramidal Cell Cereb Cortex Regular Spike Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Guillermo Gonzalez-Burgos
    • 1
  • Sven Kröner
    • 2
  • Jeremy K. Seamans
    • 3
  1. 1.Department of PsychiatryUniversity of PittsburghPittsburghUSA
  2. 2.Department of Physiology & NeuroscienceMedical University of South CarolinaCharlestonUSA
  3. 3.Brain Research CentreUniversity of British ColumbiaVancouverCanada

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