Skip to main content
SpringerLink
Log in

Neuromodulation of Cortical Synaptic Plasticity

  • Chapter
Book cover Monoaminergic Modulation of Cortical Excitability

Sensory experience can shape the synaptic connectivity of the sensory cortices during its maturation in infants, and during learning in adults. Besides sensory inputs, cortical plasticity also depends on neuromodulatory inputs conveying information on the individual’s behavioral state. As a result, experience-dependent cortical plasticity requires the individual to be awake and attentive. In contrast, passive experience usually does not leave a permanent trace on cortical connectivity. The traditional view on the neuromodulatory control of cortical plasticity has emphasized their role in increasing neural excitability, improving the signal to noise ratio, and their role in controlling the propagation of activity through the cortex. This Chapter will review the notion that neuromodulators control sensory-induced plasticity at a synaptic level by setting the gain of mechanisms like long-term potentiation (LTP) and long-term depression (LTD). We will discuss how intracellular signal generated by different neuromodulator receptors can interact with the biochemical machinery responsible for LTP and LTD. Finally, we will discuss the emerging notion that different neuromodulator receptors can specifically control LTP and LTD by regulating the trafficking of glutamate AMPA receptors in and out of the synapse.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aizenman C, Kirkwood A, Bear M (1996) Current source density analysis of evoked re-sponses in visual cortex in vitro: implications for the regulation of long-term potentiation. Cereb Cortex 6:751-758.

    Article  CAS  PubMed  Google Scholar 

  • Barria A, Muller D, Derkach V, Griffith LC, Soderling TR (1997) Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation. Science 276:2042-2045.

    Article  CAS  PubMed  Google Scholar 

  • Bear MF, Singer W (1986) Modulation of visual cortical plasticity by acetylcholine and noradrenaline. Nature 320:172-176.

    Article  CAS  PubMed  Google Scholar 

  • Bear MF, Malenka RC (1994) Synaptic plasticity: LTP and LTD. Curr Opin Neurobiol 4: 389-399.

    Article  CAS  PubMed  Google Scholar 

  • Behrends JC, ten Bruggencate G (1993) Cholinergic modulation of synaptic inhibition in the guinea pig hippocampus in vitro: excitation of GABAergic interneurons and inhibition of GABA release. J Neurophysiol 69:626-629.

    CAS  PubMed  Google Scholar 

  • Blond O, Crepel F, Otani S (2002) Long-term potentiation in rat prefrontal slices facilitated by phased application of dopamine. Eur J Pharmacol 438:115-116.

    Article  CAS  PubMed  Google Scholar 

  • Boehm J, Kang MG, Johnson RC, Esteban J, Huganir RL, Malinow R (2006) Synaptic incor-poration of AMPA receptors during LTP is controlled by a PKC phosphorylation site on GluR1. Neuron 51:213-225.

    Article  CAS  PubMed  Google Scholar 

  • Brocher S, Artola A, Singer W (1992) Agonists of cholinergic and noradrenergic receptors facilitate synergistically the induction of long-term potentiation in slices of rat visual cor-tex. Brain Res 573:27-36.

    Article  CAS  PubMed  Google Scholar 

  • Choi S, J C, Jiang B, GH S, SS M, JS H, Shin HS, Gallagher M, Kirkwood A (2005) Multiple receptors coupled to PLC gate LTD in visual cortex. J Neurosci 25:11433-11443.

    Article  CAS  PubMed  Google Scholar 

  • Cummings JA, Mulkey RM, Nicoll RA, Malenka RC (1996) Ca2+ signalling requirements for long-term depression in the hippocampus. Neuron 16:825-833.

    Article  CAS  PubMed  Google Scholar 

  • Derkach VA, Oh MC, Guire ES, Soderling TR (2007) Regulatory mechanisms of AMPA receptors in synaptic plasticity. Nat Rev Neurosci 8:101-113.

    Article  CAS  PubMed  Google Scholar 

  • Edagawa Y, Saito H, Abe K (1998) 5-HT1A receptor-mediated inhibition of long-term poten-tiation in rat visual cortex. Eur J Pharmacol 349:221-224.

    Article  CAS  PubMed  Google Scholar 

  • Edagawa Y, Saito H, Abe K (2000) The serotonin 5-HT2 receptor-phospholipase C system inhibits the induction of long-term potentiation in the rat visual cortex. Eur J Neurosci 12:1391-1396.

    Article  CAS  PubMed  Google Scholar 

  • Edagawa Y, Saito H, Abe K (2001) Endogenous serotonin contributes to a developmental decrease in long-term potentiation in the rat visual cortex. J Neurosci 21:1532-1537.

    CAS  PubMed  Google Scholar 

  • Ego-Stengel V, Shulz DE, Haidarliu S, Sosnik R, Ahissar E (2001) Acetylcholine-dependent induction and ixpression of functional plasticity in the barrel cortex of the adult rat. J Neu-rophysiol 86:422-437.

    CAS  Google Scholar 

  • Esteban JA, Shi SH, Wilson C, Nuriya M, Huganir RL, Malinow R (2003) PKA phosphoryla-tion of AMPA receptor subunits controls synaptic trafficking underlying plasticity. Nat Neurosci 6:136-143.

    Article  CAS  PubMed  Google Scholar 

  • Etkin A, Alarcon JM, Weisberg SP, Touzani K, Huang YY, Nordheim A, Kandel ER (2006) A role in learning for SRF: deletion in the adult forebrain disrupts LTD and the formation of an immediate memory of a novel context. Neuron 50:127-143.

    Article  CAS  PubMed  Google Scholar 

  • Fox K (1992) A critical period for experience-dependent synaptic plasticity in rat barrel cor-tex. J Neurosci 12:1826-1838.

    CAS  PubMed  Google Scholar 

  • Gordon B, Allen EE, Trombley PQ (1988) The role of norepinephrine in plasticity of visual cortex. Prog Neurobiol 30:171-191.

    Article  CAS  PubMed  Google Scholar 

  • Gu Q, Singer W (1993) Effects of intracortical infusion of anticholinergic drugs on neuronal plasticity in kitten striate cortex. Eur J Neurosci, 5:475-485.

    Article  CAS  PubMed  Google Scholar 

  • Gu Q, Singer W (1995) Involvement of serotonin in developmental plasticity in kitten visual cortex. Eur J Neurosci 7:1146-1153.

    Article  CAS  PubMed  Google Scholar 

  • Gurden H, Takita M, Jay TM (2000) Essential role of D1 but not D2 receptors in the NMDA receptor-dependent long-term potentiation at hippocampal-prefrontal cortex synapses in vivo. J Neurosci 20:RC106.

    CAS  PubMed  Google Scholar 

  • Kasamatsu T, Pettigrew JD (1979a) Preservation of binocularity after monocular deprivation in the striate cortex of kittens treated with 6-OHDA. J Comp Neurol 185:139-162.

    Article  CAS  PubMed  Google Scholar 

  • Kasamatsu T, Pettigrew JD (1979b) Restoration of visual cortical plasticity by local microper-fusion of norepinephrine. J Comp Neurol 185:163-182.

    Article  CAS  PubMed  Google Scholar 

  • Kasamatsu T, Watabe K, Heggelund P, Scholler E (1985) Plasticity in cat visual cortex restored by electrical stimulation of the locus coeruleus. Neurosci Res 2:365-386.

    Article  CAS  PubMed  Google Scholar 

  • Kato N (1993) Mechanisms of beta-adrenergic facilitation in rat visual cortex. Neuroreport 4:1087-1090.

    Article  CAS  PubMed  Google Scholar 

  • Kato N, Artola A, Singer W (1991) Developmental changes in the susceptibility to long-term potentiation of neurones in rat visual cortex slices. Dev Brain Res 60:43-50.

    Article  CAS  Google Scholar 

  • Kilgard MP, Merzenich MM (1998) Cortical map reorganization enabled by nucleus basalis activity. Science 279:1714-1718.

    Article  CAS  PubMed  Google Scholar 

  • Kim HS, Jang HJ, Cho KH, Hahn SJ, Kim MJ, Yoon SH, Jo YH, Kim MS, Rhie DJ (2006) Serotonin inhibits the induction of NMDA receptor-dependent long-term potentiation in the rat primary visual cortex. Brain Res 1103:49-55.

    Article  CAS  PubMed  Google Scholar 

  • Kimura F, Baughman RW (1997) Distinct muscarinic receptor subtypes suppress excitatory and inhibitory synaptic responses in cortical neurons. J Neurophysiol 77:709-716.

    CAS  PubMed  Google Scholar 

  • Kirkwood A, Lee H-K, Bear MF (1995) Co-regulation of long-term potentiation and experi-ence-dependent plasticity in visual cortex by age and experience. Nature 375:328-331.

    Article  CAS  PubMed  Google Scholar 

  • Kirkwood A, Rozas C, Kirkwood J, Perez F, Bear MF (1999) Modulation of long-term de-pression in visual cortex by acetylcholine and norepinephrine. J Neurosci 19:1599-1609.

    CAS  PubMed  Google Scholar 

  • Kojic L, Gu Q, Douglas. RM, Cynader MX (1997) Serotonin facilitates synaptic plasticity in kitten visual cortex: an in vitro study. Dev Brain Res 101:299-304.

    Article  CAS  Google Scholar 

  • Kojic L, Gu Q, Douglas RM, Cynader MS (2001) Laminar distribution of cholinergic- and serotonergic-dependent plasticity within kitten visual cortex. Dev Brain Res 126:157-162.

    Article  CAS  Google Scholar 

  • Kojic L, Dyck RH, Gu Q, Douglas. RM, Matsuraba J, Cynader MS (2000) Columnar distribu-tion of serotonin-dependent plasticity within kitten striate cortex. Proc Natl Acad Sci U S A 97:1841-1844.

    Article  CAS  PubMed  Google Scholar 

  • Lee HK (2006) Synaptic plasticity and phosphorylation. Pharmacol Ther 112:810-832.

    Article  CAS  PubMed  Google Scholar 

  • Lee HK, Barbarosie M, Kameyama K, Bear MF, Huganir RL (2000) Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity. Nature 405:955-959.

    Article  CAS  PubMed  Google Scholar 

  • Lee HK, Takamiya K, Han JS, Man H, Kim CH, Rumbaugh G, Yu S, Ding L, He C, Petralia RS, Wenthold RJ, Gallagher M, Huganir RL (2003) Phosphorylation of the AMPA recep-tor GluR1 subunit is required for synaptic plasticity and retention of spatial memory. Cell 112:631-643.

    Article  CAS  PubMed  Google Scholar 

  • Lisman J (1989) A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory. Proc Natl Acad Sci U S A 86:9574-9578.

    Article  CAS  PubMed  Google Scholar 

  • Malenka RC, Bear MF (2004) LTP and LTD: an embarrassment of riches. Neuron 44:5-21.

    Article  CAS  PubMed  Google Scholar 

  • Malinow R, Malenka RC (2002) AMPA receptor trafficking and synaptic plasticity. Annu Rev Neurosci 25:103-126.

    Article  CAS  PubMed  Google Scholar 

  • Murakoshi T (1995) Cholinergic modulation of synaptic transmission in the rat visual cortex in vitro. Vision Res 35:25-35.

    Article  CAS  PubMed  Google Scholar 

  • Osterheld-Haas MC, Van der Loos H, Hornung JP (1994) Monoaminergic afferents to cortex modulate structural plasticity in the barrelfield of the mouse. Dev Brain Res 77:189-202.

    Article  CAS  Google Scholar 

  • Otani S, Blond O, Desce JM, Crepel F (1998) Dopamine facilitates long-term depression of glutamatergic transmission in rat prefrontal cortex. Neuroscience 85:669-676.

    Article  CAS  PubMed  Google Scholar 

  • Otani S, Daniel H, Takita M, Crepel F (2002) Long-term depression induced by postsynaptic group II metabotropic glutamate receptors linked to phospholipase C and intracellular cal-cium rises in rat prefrontal cortex. J Neurosci 22:3434-3444.

    CAS  PubMed  Google Scholar 

  • Otani S, Daniel H, Roisin MP, Crepel F (2003) Dopaminergic modulation of long-term synap-tic plasticity in rat prefrontal neurons. Cereb Cortex 13:1251-1256.

    Article  PubMed  Google Scholar 

  • Roche KW, Tingley WG, Huganir RL (1994) Glutamate receptor phosphorylation and synap-tic plasticity. Curr Opin Neurobiol 4:383-388.

    Article  CAS  PubMed  Google Scholar 

  • Rozas C, Frank H, J. HA, Morales B, Bear MF, Kirkwood A (2001) Developmental inhibitory gate controls the relay of activity to the superficial layers of the visual cortex. J Neurosci-ence 21:6791-6801.

    CAS  Google Scholar 

  • Scheiderer CL, Dobrunz LE, McMahon LL (2004) Novel form of long-term synaptic depres-sion in rat hippocampus induced by activation of alpha 1 adrenergic receptors. J Neuro-physiol 91:1071-1077.

    CAS  Google Scholar 

  • Shulz DE, Sosnik R, Ego V, Haidarliu S, Ahissar E (2000) A neuronal analogue of state-dependent learning. Nature 403:549-553.

    Article  CAS  PubMed  Google Scholar 

  • Sun X, Zhao Y, Wolf ME (2005) Dopamine receptor stimulation modulates AMPA receptor synaptic insertion in prefrontal cortex neurons. J Neurosci 25:7342-7351.

    Article  CAS  PubMed  Google Scholar 

  • Thomas MJ, Moody TD, Makinson M, O’Dell TJ (1996) Activity-dependent beta-adrenergic modulation of low frequency stimulation induced LTP in the hippocampal Ca1 region. Neuron 17:475-482.

    Article  CAS  PubMed  Google Scholar 

  • Valentino RJ, Dingledine R (1981) Presynaptic inhibitory effect of acetylcholine in the hippo-campus. J Neurosci 1:784-792.

    CAS  PubMed  Google Scholar 

  • Wiesel TN, Hubel DH (1963) Single cell responses in striate cortex of kittens deprived of vision in one eye. J Neurophysiol 26:1003-1017.

    CAS  PubMed  Google Scholar 

  • Zhang LI, Bao S, Merzenich MM (2002) Disruption of primary auditory cortex by synchro-nous auditory inputs during a critical period. Proc Natl Acad Sci U S A 99:2309-2314.

    Article  CAS  PubMed  Google Scholar 

  • Zhu XO, Waite PM (1998) Cholinergic depletion reduces plasticity of barrel field cortex. Cereb Cortex 8:63-72.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Mind Brain Institute, Johns Hopkins University, 21218, Baltimore, MD, USA

    Alfredo Kirkwood

Authors
  1. Alfredo Kirkwood
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Rosalind Franklin University of Medicine and Science, 60064, North Chicago, IL, USA

    Kuei-Yuan Tseng

  2. University of Texas, 75080, Dallas, TX, USA

    Marco Atzori

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Kirkwood, A. (2007). Neuromodulation of Cortical Synaptic Plasticity. In: Tseng, KY., Atzori, M. (eds) Monoaminergic Modulation of Cortical Excitability. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-72256-6_14

Download citation

Publish with us

Policies and ethics

Search

Navigation