Dopamine and Noradrenaline Coupling in the Cerebral Cortex
The catecholaminergic innervation of rodent cerebral cortex differs in distribution of areas of dopaminergic and noradrenergic afferents. Noradrenergic innervation, originating from the locus coeruleus, is widespread and uniformly distributed throughout the cortex, predominantly in layer I (Audet et al., 1988). On the contrary, dopaminergic innervation, originating from ventral tegmental (VTA), and to a lesser degree from dorsal part of substantia nigra-pars compacta, is mainly concentrated in specific cortical areas, namely infralimbic-prelimbic, anterior cingulate and entorhinal cortices and innervates layers III, V and VI (Descarries et al., 1987). However, a consistent mismatch exists between DA innervation and its receptors. Indeed, the latter are widely spread throughout the cerebral cortex and not confined to DA innervated areas (Martres et al., 1985; Lidow et al., 1989; Richfield et al., 1989; Goldsmith and Joyce, 1994; Wedzony et al., 2000).
KeywordsCerebral Cortex Prefrontal Cortex Nucleus Accumbens Ventral Tegmental Area Locus Coeruleus
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