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Acquiring the Excitatory and the Inhibitory Action of Dopamine in the Prefrontal Cortex During Postnatal Development

  • Kuei-Yuan Tseng

In this chapter I will first review recent electrophysiological findings on how DA D1 and D2 receptors influence excitatory and inhibitory neurotransmission in the PFC during the peripubertal transition to adulthood, the cellular mechanism underlying this DA modulation as well as its functional significance. Secondly, I will discuss how a developmental disruption of PFC DA modulation may underlie some of the cortical pathophysiological changes observed in schizophrenia and related psychiatry disorders.

Keywords

Prefrontal Cortex Pyramidal Neuron GABAergic Interneuron Postnatal Development Neonatal Ventral Hippocampal Lesion 
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© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Kuei-Yuan Tseng
    • 1
  1. 1.Department of Cellular & Molecular PharmacologyRosalind Franklin University of Medicine and ScienceNorth ChicagoUSA

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