Transgenic Models of Impaired Insulin Signaling

  • Francesco Oriente
  • Domenico Accili


Insulin resistance plays a key role in the pathogenesis of several human diseases, including diabetes, obesity, hypertension and cardiovascular diseases. The predisposition to insulin resistance results from genetic and environmental factors. The search for gene variants that predispose to insulin resistance has been thwarted by its genetically heterogeneous pathogenesis. However, using techniques of targeted mutagenesis and transgenesis in rodents, investigators have developed mouse models to test critical hypotheses on the pathogenesis of insulin resistance. Moreover, experimental crosses among mutant mice have shed light onto the polygenic nature of the interactions underlying this complex metabolic condition. This review focuses on targeted mutations affecting the function of genes in the insulin signaling pathway in mice.


Insulin Resistance Insulin Secretion Insulin Receptor Insulin Signaling Brown Adipose Tissue 
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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  • Francesco Oriente
  • Domenico Accili
    • 1
  1. 1.Berrie Research PavilionNew YorkUSA

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