Characterization of Six Novel Chaperone/Usher Systems in Yersinia pestis

  • Suleyman Felek
  • Eric S. Krukonis
  • David G. Thanassi
  • Lisa M. Runco
Part of the Advances In Experimental Medicine And Biology book series (AEMB, volume 603)

Yersinia pestis, the causative agent of plague, is a gram-negative pathogen that evolved from Yersinia pseudotuberculosis 1,500-20,000 years ago (Achtman et al. 1999). Plague has ravaged human populations for centuries and continues to occur in outbreaks throughout the world (Cantor 2001; Perry and Fetherston 1997). Y. pestis is usually transmitted by fleas that have fed on infected rodents prior to biting their human hosts. A number of virulence factors have been described in Y. pestis that contribute to disease including the 70-kb Yop-encoding plasmid pCD1 (Cornelis et al. 1998), plasminogen activator (Sodeinde et al. 1992), iron acquisition functions (Brubaker et al. 1965) and a surface-localized adhesin pH 6 antigen (Lindler et al. 1990).


Yersinia Pestis Crystal Violet Staining Polystyrene Culture Plate Surface Appendage Bubonic Plague 
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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Suleyman Felek
    • 1
  • Eric S. Krukonis
    • 2
  • David G. Thanassi
    • 3
  • Lisa M. Runco
    • 3
  1. 1.Department of Biologic and Materials SciencesUniversity of Michigan School of DentistryAnn ArborUSA
  2. 2.Department of Microbiology and ImmunologyUniversity of Michigan School of MedicineAnn ArborUSA
  3. 3.Department of Molecular Genetics and MicrobiologyState University of New YorkStony BrookUSA

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