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Protective Immunity Against Plague

  • Claire Cornelius
  • Olaf Schneewind
  • Deborah Anderson
  • Lauriane Quenee
Part of the Advances In Experimental Medicine And Biology book series (AEMB, volume 603)

Plague, an infectious disease that reached catastrophic proportions during three pandemics, continues to be a legitimate public health concern worldwide. Although antibiotic therapy for the causative agent Yersinia pestis is available, pharmaceutical supply limitations, multi-drug resistance from natural selection as well as malicious bioengineering are a reality. Consequently, plague vaccinology is a priority for biodefense research. Development of a multi-subunit vaccine with Fraction 1 and LcrV as protective antigens seems to be receiving the most attention. However, LcrV has been shown to cause immune suppression and Y. pestis mutants lacking F1 expression are thought to be fully virulent in nature and in animal experiments. The LcrV variant, rV10, retains the well documented protective antigenic properties of LcrV but with diminished inhibitory effects on the immune system. More research is required to examine the molecular mechanisms of vaccine protection afforded by surface protein antigens and to decipher the host mechanisms responsible for vaccine success.

Keywords

Protective Immunity Protective Antigen Yersinia Enterocolitica Yersinia Pestis Pneumonic Plague 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Claire Cornelius
    • 1
  • Olaf Schneewind
    • 1
  • Deborah Anderson
    • 1
  • Lauriane Quenee
    • 1
  1. 1.Department of MicrobiologyUniversity of ChicagoChicagoUSA

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