Invasion and Dissemination of Yersinia enterocolitica in the Mouse Infection Model
Yersinia enterocolitica is one of the most common causes of food borne gastrointestinal disease. After oral uptake yersiniae replicate in the small intestine, invade Peyeŕs patches of the distal ileum and disseminate to spleen and liver. In these tissues and organs yersiniae replicate extracellularly and form exclusively monoclonal microabscesses. Only very few yersiniae invade Peyeŕs patches and establish just a very few monoclonal microabscesses. This is due to both Yersinia and host specific factors.
KeywordsMesenteric Lymph Node Distal Ileum Yersinia Enterocolitica Oral Infection Mouse Infection Model
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- Autenrieth, I.B., Vogel, U., Preger, S., Heymer, B. and Heesemann, J. (1993) Experimental Yersinia enterocolitica infection in euthymic and T-cell-deficient athymic nude C57BL/6 mice: comparison of time course, histomorphology, and immune response. Infect. Immun. 61, 2585-2595.PubMedPubMedCentralGoogle Scholar
- Hanski, C., Kutschka, U, Schmoranzer, H.P., Naumann, M., Stallmach, A., Hahn, H., Menge, H. and Riecken, E.O. (1989) Immunohistochemical and electron microscopic study of interaction of Yersinia enterocolitica serotype O8 with intestinal mucosa during experimental enteritis. Infect. Immun. 57, 673-678.PubMedPubMedCentralGoogle Scholar
- Oellerich, M., Jacobi, C., Freund, S., Niedung, K., Bach, A., Heesemann, J. and Trülzsch, K. (2007) Yersinia enterocolitica infection of mice reveals clonal invasion and abscess for-mation. submitted for publication.Google Scholar
- Simonet, M., Richard, S. and Berche, P. (1990) Electron microscopic evidence for in vivo extracellular localization of Yersinia pseudotuberculosis harboring the pYV plasmid. In-fect. Immun. 58, 841-845.Google Scholar