Twin Arginine Translocation in Yersinia

  • Moa Lavander
  • Åke Forsberg
  • Jeanette E. Bröms
  • Solveig K. Ericsson
Part of the Advances In Experimental Medicine And Biology book series (AEMB, volume 603)

Bacteria utilise Twin arginine translocation (Tat) to deliver folded proteins across the cytoplasmic membrane. Disruption of Tat typically results in pleiotropic effects on e.g. growth, stress resistance, bacterial membrane biogenesis, motility and cell morphology. Further, Tat is coupled to virulence in a range of pathogenic bacteria, including species of Pseudomonas, Legionella, Agrobacterium and Mycobacterium. We have investigated this, for Yersinia, previously unexplored system, and have shown that the Tat pathway is functional and absolutely required for virulence of Yersinia pseudotuberculosis. A range of putative Yersinia Tat substrates have been predicted in silico, which together with the Tat system itself may be interesting targets for future development of antimicrobial treatments. Here we present a brief review of bacterial Tat and discuss our results concerning this system in Yersinia.


Yersinia Pestis Twin Arginine Translocation Twin Arginine Isogenic Wild Type Swedish Defence Research Agency 


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Moa Lavander
    • 1
  • Åke Forsberg
    • 2
  • Jeanette E. Bröms
    • 2
  • Solveig K. Ericsson
    • 2
  1. 1.DiseasesSwedish Defence Research AgencySweden
  2. 2.Department of Medical Countermeasures, Division of NBC DefenceSwedish Defence Research AgencySweden

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