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Comparative Genome Analyses of the Pathogenic Yersiniae Based on the Genome Sequence of Yersinia enterocolitica Strain 8081

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The Genus Yersinia

Part of the book series: Advances In Experimental Medicine And Biology ((AEMB,volume 603))

This chapter represents a summary of the findings from the Yersinia enterocolitica strain 8081 whole genome sequence and the associated microarray analysis. Section 1 & 2 provide an introduction to the species and an overview of the general features of the genome. Section 3 identifies important regions within the genome which highlight important differences in gene function that separate the three pathogenic Yersinias. Section 4 describes genomic loci conferring important, species-specific, metabolic and virulence traits. Section 5 details extensive microarray data to provide an overview of species-specific core Y. enterocolitica gene functions and important insights into the intra-species differences between the high, low and non-pathogenic Y. enterocolitica biotypes.

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References

  • Achtman, M., Morelli, G., Zhu, P., Wirth, T., Diehl, I., Kusecek, B., Vogler, A.J., Wagner, D.M., Allender, C.J., Easterday, W.R., Chenal-Francisque, V., Worsham, P., Thomson, N.R., Parkhill, J., Lindler, L.E., Carniel, E. and Keim, P. (2004) Microevolution and his-tory of the plague bacillus, Yersinia pestis. Proc. Natl. Acad. Sci. USA 101, 17837-17842.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Achtman, M., Zurth, K., Morelli, G., Torrea, G., Guiyoule, A. and Carniel, E. (1999) Yersinia pestis, the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis. Proc. Natl. Acad. Sci. USA 96, 14043-14048.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Campbell, A. (2003) Prophage insertion sites. Res Microbiol. 154, 277-282.

    Article  CAS  PubMed  Google Scholar 

  • Chain, P.S., Carniel, E., Larimer, F.W., Lamerdin, J., Stoutland, P.O., Regala, W.M., Georgescu, A.M., Vergez, L.M., Land, M.L., Motin, V.L., Brubaker, R.R., Fowler, J., Hinnebusch, J., Marceau, M., Medigue, C., Simonet, M., Chenal-Francisque, V., Souza, B., Dacheux, D., Elliott, J.M., Derbise, A., Hauser, L.J. and Garcia, E. (2004) Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis. Proc. Natl. Acad. Sci. USA 101, 13826-13831.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Collyn, F., Billault, A., Mullet, C., Simonet, M. and Marceau, M. (2004) YAPI, a new Yersinia pseudotuberculosis pathogenicity island. Infect. Immun. 72, 4784-4790.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Collyn, F., Guy, L., Marceau, M., Simonet, M. and Roten, C.A. (2006) Describing ancient horizontal gene transfers at the nucleotide and gene levels by comparative pathogenicity island genometrics. Bioinformatics 22, 1072-1079.

    Article  CAS  PubMed  Google Scholar 

  • Day, W.A., Jr., Fernandez, R.E. and Maurelli, A.T. (2001) Pathoadaptive mutations that en-hance virulence: genetic organization of the cadA regions of Shigella spp. Infect. Immun. 69, 7471-7480.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Deng, W., Burland, V., Plunkett, G., 3rd, Boutin, A., Mayhew, G.F., Liss, P., Perna, N.T., Rose, D.J., Mau, B., Zhou, S., Schwartz, D.C., Fetherston, J.D., Lindler, L.E., Brubaker, R.R., Plano, G.V., Straley, S.C., McDonough, K.A., Nilles, M.L., Matson, J.S., Blattner, F.R. and Perry, R.D. (2002) Genome sequence of Yersinia pestis KIM. J. Bacteriol. 184, 4601-4611.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Foultier, B., Troisfontaines, P., Muller, S., Opperdoes, F.R. and Cornelis, G.R. (2002) Charac-terization of the ysa pathogenicity locus in the chromosome of Yersinia enterocolitica and phylogeny analysis of type III secretion systems. J. Mol. Evol. 55, 37-51.

    Article  CAS  PubMed  Google Scholar 

  • Haller, J.C., Carlson, S., Pederson, K.J. and Pierson, D.E. (2000) A chromosomally encoded type III secretion pathway in Yersinia enterocolitica is important in virulence. Mol. Mi-crobiol. 36, 1436-1446.

    Article  CAS  Google Scholar 

  • Howard, S.L., Gaunt, M.W., Hinds, J., Witney, A.A., Stabler, R. and Wren, B.W. (2006) Application of comparative phylogenomics to study the evolution of Yersinia enterocol-itica and to identify genetic differences relating to pathogenicity. J. Bacteriol. 188, 3645-3653.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Iwobi, A., Heesemann, J., Garcia, E., Igwe, E., Noelting, C. and Rakin, A. (2003) Novel viru-lence-associated type II secretion system unique to high-pathogenicity Yersinia enterocoli-tica. Infect. Immun. 71, 1872-1879.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kachlany, S.C., Planet, P.J., Bhattacharjee, M.K., Kollia, E., DeSalle, R., Fine, D.H. and Figurski, D.H. (2000) Nonspecific adherence by Actinobacillus actinomycetemcomitans requires genes widespread in bacteria and archaea. J. Bacteriol. 182, 6169-6176.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lawrence, J.G. and Roth, J.R. (1996) Evolution of coenzyme B12 synthesis among enteric bacteria: evidence for loss and reacquisition of a multigene complex. Genetics 142, 11-24.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Maier, R.J. (2005) Use of molecular hydrogen as an energy substrate by human pathogenic bacteria. Biochem. Soc. Trans. 33, 83-85.

    Article  CAS  PubMed  Google Scholar 

  • Maier, R.J., Olczak, A., Maier, S., Soni, S. and Gunn, J. (2004) Respiratory hydrogen use by Salmonella enterica serovar Typhimurium is essential for virulence. Infect. Immun. 72, 6294-6299.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Matsumoto, H. and Young, G.M. (2006) Proteomic and functional analysis of the suite of Ysp proteins exported by the Ysa type III secretion system of Yersinia enterocolitica Biovar 1B. Mol. Microbiol. 59, 689-706.

    Article  CAS  PubMed  Google Scholar 

  • McNally, A., Cheasty, T., Fearnley, C., Dalziel, R.W., Paiba, G.A., Manning, G. and Newell, D.G. (2004) Comparison of the biotypes of Yersinia enterocolitica isolated from pigs, cattle and sheep at slaughter and from humans with yersiniosis in Great Britain during 1999-2000. Lett. Appl. Microbiol. 39, 103-108.

    Article  CAS  PubMed  Google Scholar 

  • Mohd-Zain, Z., Turner, S.L., Cerdeno-Tarraga, A.M., Lilley, A.K., Inzana, T.J., Duncan, A.J., Harding, R.M., Hood, D.W., Peto, T.E. and Crook, D.W. (2004) Transferable antibiotic resistance elements in Haemophilus influenzae share a common evolutionary origin with a diverse family of syntenic genomic islands. J. Bacteriol. 186, 8114-8122.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Olson, J.W. and Maier, R.J. (2002) Molecular hydrogen as an energy source for Helicobacter pylori. Science 298, 1788-1790.

    Article  CAS  PubMed  Google Scholar 

  • Parkhill, J., Wren, B.W., Thomson, N.R., Titball, R.W., Holden, M.T., Prentice, M.B., Sebaihia, M., James, K.D., Churcher, C., Mungall, K.L., Baker, S., Basham, D., Bentley, S.D., Brooks, K., Cerdeno-Tarraga, A.M., Chillingworth, T., Cronin, A., Davies, R.M., Davis, P., Dougan, G., Feltwell, T., Hamlin, N., Holroyd, S., Jagels, K., Karlyshev, A.V., Leather, S., Moule, S., Oyston, P.C., Quail, M., Rutherford, K., Simmonds, M., Skelton, J., Stevens, K., Whitehead, S. and Barrell, B.G. (2001) Genome sequence of Yersinia pestis, the causative agent of plague. Nature. 413, 523-527.

    Article  CAS  PubMed  Google Scholar 

  • Perry, R.D. and Fetherston, J.D. (1997) Yersinia pestis--etiologic agent of plague. Clin. Micro-biol. Rev. 10, 35-66.

    CAS  Google Scholar 

  • Pickard, D., Wain, J., Baker, S., Line, A., Chohan, S., Fookes, M., Barron, A., Gaora, P.O., Chabalgoity, J.A., Thanky, N., Scholes, C., Thomson, N., Quail, M., Parkhill, J. and Dougan, G. (2003) Composition, acquisition, and distribution of the Vi exopolysaccharide-encoding Salmonella enterica pathogenicity island SPI-7. J. Bacteriol. 185, 5055-5065

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Prentice, M.B., Cope, D. and Swann, R.A. (1991) The epidemiology of Yersinia enterocolitica infection in the British Isles 1983-1988. Contrib. Microbiol. Immunol. 12, 17-25.

    CAS  PubMed  Google Scholar 

  • Rosqvist, R., Skurnik, M. and Wolf-Watz, H. (1988) Increased virulence of Yersinia pseudotu-berculosis by two independent mutations. Nature 334, 522-524.

    Article  CAS  PubMed  Google Scholar 

  • Schreiner, H.C., Sinatra, K., Kaplan, J.B., Furgang, D., Kachlany, S.C., Planet, P.J., Perez, B.A., Figurski, D.H. and Fine, D.H. (2003) Tight-adherence genes of Actinobacillus actinomycetemcomitans are required for virulence in a rat model. Proc. Natl. Acad. Sci. USA 100, 7295-7300.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schubert, S., Fischer, D. and Heesemann, J. (1999) Ferric enterochelin transport in Yersinia enterocolitica: molecular and evolutionary aspects. J. Bacteriol. 181, 6387-6395.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Schubert, S., Rakin, A. and Heesemann, J. (2004) The Yersinia high-pathogenicity island (HPI): evolutionary and functional aspects. Int. J. Med. Microbiol. 294, 83-94.

    Article  CAS  PubMed  Google Scholar 

  • Sekowska, A., Denervaud, V., Ashida, H., Michoud, K., Haas, D., Yokota, A. and Danchin, A. (2004) Bacterial variations on the methionine salvage pathway. BMC Microbiol. 4, 9.

    Article  PubMed  PubMed Central  Google Scholar 

  • Song, Y., Tong, Z., Wang, J., Wang, L., Guo, Z., Han, Y., Zhang, J., Pei, D., Zhou, D., Qin, H., Pang, X., Zhai, J., Li, M., Cui, B., Qi, Z., Jin, L., Dai, R., Chen, F., Li, S., Ye, C., Du, Z., Lin, W., Yu, J., Yang, H., Huang, P. and Yang, R. (2004) Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans. DNA Res. 11, 179-197.

    Article  CAS  PubMed  Google Scholar 

  • Thomson, N.R., Howard, S., Wren, B.W., Holden, M.T., Crossman, L., Challis, G.L., Churcher, C., Mungall, K., Brooks, K., Chillingworth, T., Feltwell, T., Abdellah, Z., Hauser, H., Jagels, K., Maddison, M., Moule, S., Sanders, M., Whitehead, S., Quail, M.A., Dougan, G., Parkhill, J. and Prentice, M.B. (2006) The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081. PLoS Genet 2, e206.

    Article  PubMed  PubMed Central  Google Scholar 

  • Van Noyen, R., Vandepitte, J., Wauters, G. and Selderslaghs, R. (1981) Yersinia enterocoli tica: its isolation by cold enrichment from patients and healthy subjects. J. Clin. Pathol. 34, 1052-1056.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wauters, G., Kandolo, K. and Janssens, K. (1987) Revised biogrouping scheme of Yersinia enterocolitica. Contrib. Microbiol. Immunol. 9, 14-21.

    CAS  PubMed  Google Scholar 

  • Wren, B.W. (2003) The yersiniae-a model genus to study the rapid evolution of bacteria pathogens. Nat. Rev. Microbiol. 1, 55-64.

    Article  CAS  PubMed  Google Scholar 

  • Zogaj, X., Nimtz, M., Rohde, M., Bokranz, W. and Romling, U. (2001) The multi-cellular morphotypes of Salmonella typhimurium and Escherichia coli produce cellulose as the second component of the extracellular matrix. Mol. Microbiol. 39, 1452-1463.

    Article  CAS  PubMed  Google Scholar 

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Thomson, N.R., Prentice, M.B., Wren, B.W., Howard, S. (2007). Comparative Genome Analyses of the Pathogenic Yersiniae Based on the Genome Sequence of Yersinia enterocolitica Strain 8081. In: Perry, R.D., Fetherston, J.D. (eds) The Genus Yersinia. Advances In Experimental Medicine And Biology, vol 603. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72124-8_1

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