Comparative Genome Analyses of the Pathogenic Yersiniae Based on the Genome Sequence of Yersinia enterocolitica Strain 8081

  • Nicholas R. Thomson
  • Michael B. Prentice
  • Brendan W. Wren
  • Sarah Howard
Part of the Advances In Experimental Medicine And Biology book series (AEMB, volume 603)

This chapter represents a summary of the findings from the Yersinia enterocolitica strain 8081 whole genome sequence and the associated microarray analysis. Section 1 & 2 provide an introduction to the species and an overview of the general features of the genome. Section 3 identifies important regions within the genome which highlight important differences in gene function that separate the three pathogenic Yersinias. Section 4 describes genomic loci conferring important, species-specific, metabolic and virulence traits. Section 5 details extensive microarray data to provide an overview of species-specific core Y. enterocolitica gene functions and important insights into the intra-species differences between the high, low and non-pathogenic Y. enterocolitica biotypes.


Comparative Genome Analysis Genomic Island Yersinia Enterocolitica Yersinia Pestis Yersinia Species 


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Nicholas R. Thomson
    • 1
  • Michael B. Prentice
    • 2
  • Brendan W. Wren
    • 3
  • Sarah Howard
    • 3
  1. 1.The Pathogen Sequencing Unit, Wellcome Trust Genome CampusThe Wellcome Trust Sanger InstituteUK
  2. 2.Department of Microbiology, Department of PathologyUniversity College CorkIreland
  3. 3.Department of Infectious and Tropical DiseasesLondon School of Hygiene and Tropical MedicineUK

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