Neuroendocrine Tumors

  • Samuel P. Hammar


Of all neoplasms that occur in the body, few have been studied or written about as much as neuroendocrine lung tumors. Neuroendocrine lung neoplasms exhibit a wide variety of morphologic appearances, ranging from typical carcinoid to small cell (undifferentiated) carcinoma (small cell lung cancer [SCLC]). A conceptual understanding of these neoplasms is based on knowledge of the neuroendocrine cell system and the evolution of the amine precursor uptake and decarboxylase (APUD) concept.


Small Cell Carcinoma Neuroendocrine Carcinoma Small Cell Lung Carcinoma Large Cell Carcinoma Atypical Carcinoid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Feyrter F. Ueber diffuse endokrine epitheliate organe. Zentralbl Inn Med 1938;59:545–561.Google Scholar
  2. 2.
    Pearse AGE. The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of this concept. J Histochem Cytochem 1969;17:303–313.PubMedGoogle Scholar
  3. 3.
    Pearse AGE, Takor T. Embyrology of the diffuse neuroendocrine system and its relationship to the common peptides. Fed Proc 1979;38:2288–2294.PubMedGoogle Scholar
  4. 4.
    Pearse AGE. The diffuse neuroendocrine system: an extension of the APUD concept. In: Taylor S, ed. Endocrinology. London: Heinemann, 1972:145.Google Scholar
  5. 5.
    Gould VE, DeLellis RA. The neuroendocrine cell system: its tumors, hyperplasias, and dysplasias. In: Silverberg SG, ed. Principles and practice of surgical pathology. New York: Wiley, 1983:1488–1501.Google Scholar
  6. 6.
    Gould VE, Moll R, Moll I, Lee I, Franke WW. Neuroendocrine (Merkel) cells of the skin: hyperplasias, dysplasias and neoplasms. Lab Invest 1985;52:334–353.PubMedGoogle Scholar
  7. 7.
    Gould VE, Linnoila RI, Memoli VA, Warren WH. Neuroendocrine components of the bronchopulmonary tract: hyperplasias, dysplasias, and neoplasms. Lab Invest 1983;49:519–537.PubMedGoogle Scholar
  8. 8.
    Gould VE, Wiedenmann B, Lee I, et al. Synaptophysin expression in neuroendocrine neoplasms as determined by immunocytochemistry. Am J Pathol 1987;126:243–257.PubMedGoogle Scholar
  9. 9.
    Hammar S, Gould VE. Neuroendocrine neoplasms. In: Azar HA, ed. Pathology of human neoplasms: an atlas of diagnostic electron microscopy and immunohistochemistry. New York: Raven Press, 1988:333–404.Google Scholar
  10. 10.
    Barnes PJ, Baranivk JN, Belvisi MG. Neuropeptides in the respiratory tract. Am Rev Respir Dis 1991;144(1):1187–1198;(2):1391–1399.PubMedGoogle Scholar
  11. 11.
    Haimoto H, Takahashi Y, Koshikawa T, Nagura H, Kato K. Immunohistochemical localization of γ-enolase in normal human tissues other than nervous and neuroendocrine tissues. Lab Invest 1985;52:257–263.PubMedGoogle Scholar
  12. 12.
    Pahlman S, Esscher T, Nilsson K. Expression of γ-subunit of enolase, neuron-specific enolase in human nonneuroendocrine tumors and derived cell lines. Lab Invest 1986;54:554–560.PubMedGoogle Scholar
  13. 13.
    Vinores SA, Bonnin JM, Rubinstein LJ, Marangos PJ. Immunohistochemical demonstration of neuron-specific enolase in neoplasms of the CNS and other tissues. Arch Pathol Lab Med 1984;120:186–192.Google Scholar
  14. 14.
    Bergh J, Escher T, Steinholtz L, Nilsson K, Pahlman S. Immunocytochemical demonstration of neuron-specific enolase (NSE) in human lung cancers. Am J Clin Pathol 1985;84:1–7.PubMedGoogle Scholar
  15. 15.
    Said JW, Vimadalal S, Nash G, et al. Immunoreactive neuron-specific enolase, bombesin, and chromogranin as markers for neuroendocrine lung tumors. Hum Pathol 1985;16:236–240.PubMedCrossRefGoogle Scholar
  16. 16.
    Schmechel DE. γ-subunit of the glycolytic enzyme enolase: nonspecific or neuron specific? Lab Invest 1985;52:239–242.PubMedGoogle Scholar
  17. 17.
    O’Connor DT, Burton D, Deftos LJ. Immunoreactive human chromogranin A in diverse polypeptide hormone producing human tumors and normal endocrine tissues. J Clin Endocrinol Metab 1983;57:1084–1086.PubMedCrossRefGoogle Scholar
  18. 18.
    Lloyd RV, Wilson BS, Kovacs K, Ryan N. Immunohistochemical localization of chromogranin in human hypophyses and pituitary adenomas. Arch Pathol Lab Med 1985;109:515–517.PubMedGoogle Scholar
  19. 19.
    McNutt MA, Bolen JW. Adenomatous tumor of the middle ear. Am J Clin Pathol 1985;84:541–547.PubMedGoogle Scholar
  20. 20.
    Bussolati G, Gugliotta P, Sapino A, Eusebi V, Lloyd R. Chromogranin-reactive endocrine cells in argyrophilic carcinomas (“carcinoids”) from normal tissue of the breast. Am J Pathol 1985;120:186–192PubMedGoogle Scholar
  21. 21.
    O’Connor DT, Deftos LJ. Secretion of chromogranin A by peptide-producing endocrine neoplasms. N Engl J Med 1986;314:1145–1151.PubMedGoogle Scholar
  22. 22.
    Lloyd RV, Sisson JC, Shapiro B, Verhofstad AAJ. Immunohistochemical localization of epinephrine, norepinephrine, catecholamine-synthesizing enzymes and chromogranin in neuroendocrine cells and tumors. Am J Pathol 1986;125:45–54.PubMedGoogle Scholar
  23. 23.
    Banks P, Helle K. The release of protein from the stimulated adrenal medulla. Biochem J 1965;97:40C–41C.PubMedGoogle Scholar
  24. 24.
    Angeletti RH. Chromogranins and neuroendocrine secretion. Lab Invest 1986;55:387–390.PubMedGoogle Scholar
  25. 25.
    Wilson BS, Lloyd RV. Detection of chromogranin in neuroendocrine cells with a monoclonal antibody. Am J Pathol 1984;115:458–468.PubMedGoogle Scholar
  26. 26.
    Lauweryns JM, vanRanst K, Lloyd RV, et al. Chromogranin in bronchopulmonary neuroendocrine cells: immunohistochemical detection in human, monkey and pig respiratory mucosa. J Histochem Cytochem 1987;35:113–118.PubMedGoogle Scholar
  27. 27.
    Mukai M, Torikata C, Iri H, et al. Expression of neurofilament triplet proteins in human neural tumor: an immunohistochemical study of paraganglioma, ganglioneuroma, ganglioneuroblastoma and neuroblastoma. Am J Pathol 1986;122:28–36.PubMedGoogle Scholar
  28. 28.
    Shah IA, Schlageter M, Netto D. Immunoreactivity of neurofilament proteins in neuroendocrine neoplasms. Mod Pathol 1991;4:215–219.PubMedGoogle Scholar
  29. 29.
    Leoncini P, DeMarco EB, Bugnoli M, Mencarelli C, Vindigni C, Cintorino M. Expression of phosphorylated and non-phosphorylated neurofilament subunits and cytokeratins in neuroendocrine lung tumors. Pathol Res Pract 1989;185:848–855.PubMedGoogle Scholar
  30. 30.
    Jahn B, Schibler W, Ouimet C, et al. A 38,000 dalton membrane protein (p38) present in synaptic vesicles. Proc Natl Acad Sci USA 1985;82:4137–4141.PubMedCrossRefGoogle Scholar
  31. 31.
    Gould VE, Lee I, Wiedenmann B, Moll R, Chejfec G, Franke WW. Synaptophysin: a novel marker for neurons, certain neuroendocrine cells and their neoplasms. Hum Pathol 1986;17:979–983.PubMedCrossRefGoogle Scholar
  32. 32.
    Bunn P, Linnoila I, Minna J, Carney D, Gazdar AF. Small cell cancer, endocrine cells of the fetal bronchus, and other neuroendocrine cells express Leu7 antigenic determinant present on natural killer cells. Blood 1985;65:764–768.PubMedGoogle Scholar
  33. 33.
    Tsutsumi Y. Leu7 immunoreactivity as a histochemical marker for paraffin-embedded neuroendocrine tumors. Acta Histochem Cytochem 1984;17:15.Google Scholar
  34. 34.
    Tischler AS, Mobtaker H, Mann K, et al. Anti-lymphocyte monoclonal antibody HNK-1 (Leu7) recognizes a constituent of neuroendocrine matrix. Lab Invest I 986;54:64A.Google Scholar
  35. 35.
    Komminoth P, Roth J, Lackie PM, Bitter-Suermann D, Heitz PU. Polysialic acid of the neural cell adhesion molecule distinguishes small cell lung carcinoma from carcinoids. Am J Pathol 1991;139:297–304.PubMedGoogle Scholar
  36. 36.
    Kibbelaar RE, Moolenaar CEC, Michalides RJAM, Bitter-Suermann D, Addis BJ, Mooi WJ. Expression of the embryonal neural cell adhesion molecular N-CAM in lung carcinoma. Diagnostic usefulness of monoclonal antibody 735 for the distinction between small cell lung cancer and non-small cell lung cancer. J Pathol 1989;159:23–28.PubMedCrossRefGoogle Scholar
  37. 37.
    Moolenaar CE, Muller EJ, Schol DJ. Expression of neural cell adhesion molecule-related sialoglycoprotein in small cell lung cancer, and neuroblastoma cell lines H69 and CHP-212. Cancer Res 1990;50:1102–1106.PubMedGoogle Scholar
  38. 38.
    Stahlman M, Gray M, Whitsett J. Expression of thyroid transcription factor 1 (TTF-1) in fetal and neonatal human lung. J Histochem Cytochem 1996;44:673–678.PubMedGoogle Scholar
  39. 39.
    Lazzaro D, Price M, DeFelice M, et al. The transcription factor 1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the fetal brain. Development 1991;113:1093–1104.PubMedGoogle Scholar
  40. 40.
    Holzinger A, Dingle S, Bejarano P, et al. Monoclonal antibody to thyroid transcription factor-1: production, characterization, and usefulness in tumor diagnosis. Hybridoma 1996;15:49–53.PubMedCrossRefGoogle Scholar
  41. 41.
    DiLoreto C, DiLauro V, Puglisi F, et al. Immunohistochemical expression of tissue specific transcription factor-1 in lung carcinoma. J Clin Pathol 1997;50:30–32.CrossRefGoogle Scholar
  42. 42.
    Fabbro D, DiLoreto C, Stamerra O, et al. TTF-1 expression in human lung tumours. Eur J Cancer 1996;32A:512–517.PubMedCrossRefGoogle Scholar
  43. 43.
    Harlamert H, Mira J, Bejarano P, et al. Thyroid transcription factor-1 and cytokeratins 7 and 20 in pulmonary and breast carcinoma. Acta Cytol 1998;42:1382–1388.PubMedGoogle Scholar
  44. 44.
    Byrd-Gloster A, Khoor A, Glass L, et al. Differential expression of thyroid transcription factor 1 in small cell lung carcinoma and Merkel cell tumor. Hum Pathol 2000;31:58–62.PubMedCrossRefGoogle Scholar
  45. 45.
    Folpe A, Gown A, Lamps L, et al. Thyroid transcription factor-1: immunohistochemical evaluation in pulmonary neuroendocrine tumors. Mod Pathol 1999;12:5–8.PubMedGoogle Scholar
  46. 46.
    Hanly A, Elgart G, Jorda M, et al. Analysis of thyroid transcription factor-1 and cytokeratin 20 separates Merkel cell carcinoma from small cell carcinoma of lung. J Cutan Pathol 2000;27:118–120.PubMedCrossRefGoogle Scholar
  47. 47.
    Kaufmann O, Dietel M. Expression of thyroid transcription factor-1 in pulmonary and extrapulmonary small cell carcinomas and other neuroendocrine carcinomas of various primary sites. Histopathology 2000;36:415–429.PubMedCrossRefGoogle Scholar
  48. 48.
    Sturm N, Lanteujoul S, Lavierriere M, et al. Thyroid transcription factor-1 (TTF-1) and cytokeratin 1, 5, 10, 14 (34betaE12) expression in basaloid and large cell neuroendocrine carcinomas of the lung. Hum Pathol 2001;32:918–925.PubMedCrossRefGoogle Scholar
  49. 49.
    Oliveira A, Tazelaar H, Myers J, et al. Thyroid transcription factor-1 distinguishes metastatic pulmonary from well-differentiated neuroendocrine tumors of other sites. Am J Surg Pathol 2001;25:815–819.PubMedCrossRefGoogle Scholar
  50. 50.
    Sturm N, Rossi G, Lanteujoul S, et al. Expression of thyroid transcription factor-1 in the spectrum of neuroendocrine cell lung proliferations with special interest in carcinoids. Hum Pathol 2002;33:175–182.PubMedCrossRefGoogle Scholar
  51. 51.
    Saqi A, Alexis D, Remotti F, et al. Usefulness of CDX2 and TTF-1 in differentiating gastrointestinal from pulmonary carcinoids. Am J Clin Pathol 2005;123:394–404.PubMedCrossRefGoogle Scholar
  52. 52.
    Lonardo F, Pass HI, Lucas DR. Immunohistochemistry frequently detects c-Kit expression in pulmonary small cell carcinoma and may help select clinical subsets for a novel form of chemotherapy. Appl Immunohist Mol Morphol 2003;11:51–55.CrossRefGoogle Scholar
  53. 53.
    Casali C, Stefani A, Rossi G, et al. The prognostic role of c-Kit protein expression in resected large cell neuroendocrine carcinoma of the lung. Ann Thorac Surg 2004;77:252–253.CrossRefGoogle Scholar
  54. 54.
    Butnor KJ, Burchette JL, Sporn TA, Hammar SP, Roggli VL. The spectrum of c-Kit (CD117) immunoreactivity in lung and pleural tumors: a study of 96 cases using a singlesource antibody with a review of the literature. Arch Pathol Lab Med 2004;128:538–543.PubMedGoogle Scholar
  55. 55.
    Yesner R. Spectrum of lung cancer and ectopic hormones. Pathol Annu 1978;13(pt 1):217–240.Google Scholar
  56. 56.
    Kahn HJ, Garrido A, Huang S-N, Baumal R. Intermediate filaments and tumor diagnosis. Lab Invest 1983;49:509.Google Scholar
  57. 57.
    Lehto V-P, Stenman S, Miettinen M, Dahl D, Virtanen I. Expression of a neural type of intermediate filament as a distinguishing feature between oat cell carcinoma and other lung cancers. Am J Pathol 1983;110:113–118.PubMedGoogle Scholar
  58. 58.
    VanMuijen GNP, Ruiter DJ, Leeuwen CV, Prins FA, Rietsema K, Warnaar SO. Cytokeratin and neurofilament in lung carcinomas. Am J Pathol 1984;116:363–369.Google Scholar
  59. 59.
    Lehto V-P, Miettinen M, Dahl D, Virtanen I. Bronchial carcinoid cells contain neural-type intermediate filaments. Cancer (Philadelphia) 1984;54:624–628.CrossRefGoogle Scholar
  60. 60.
    Clark RK, Miettinen M, Leij L, Damjanov I. Terminally differentiated derivatives of pulmonary small cell carcinomas may contain neurofilaments. Lab Invest 1985;53:243–244.PubMedGoogle Scholar
  61. 61.
    Broers J, Huysmans A, Moesker O, Vooijs P, Ramaekers F, Wagenaar S. Small cell lung cancer contains intermediate filaments of the cytokeratin type. Lab Invest 1985;52:113–114.PubMedGoogle Scholar
  62. 62.
    Moll R, Franke WW, Schiller DL, et al. The catalogue of human cytokeratins. Patterns of expression in normal epithelia, tumors and cultured cells. Cell 1982;31:11–24.PubMedCrossRefGoogle Scholar
  63. 63.
    Cooper D, Schermer A, Sun T-T. Classification of human epithelia and their neoplasms using monoclonal antibodies to keratins: strategies, applications and limitations. Lab Invest 1985;52:243–256.PubMedGoogle Scholar
  64. 64.
    Gown AM, Gabbiani G. Intermediate-sized (10-nm) filaments in human tumors. In: DeLellis, RA, ed. Advances in immunohistochemistry. New York: Masson, 1984:89–109.Google Scholar
  65. 65.
    Miettinen M, Lehto V-P, Virtanen I. Antibodies to intermediate filament proteins in the diagnosis and classification of human tumors. Ultrastruct Pathol 1984;7:83–107.PubMedCrossRefGoogle Scholar
  66. 66.
    Moll R, Cowin P, Kapprell H-P, Franke WW. Desmosomal proteins: new markers for identification and classification of tumors. Lab Invest 1986;54:4–25.PubMedGoogle Scholar
  67. 67.
    Funa K, Gazdar AF, Minna JD, Linnoila RI. Paucity of B2-microglobulin expression on small cell lung cancer, bronchial carcinoids, and certain other neuroendocrine tumors. Lab Invest 1986;55:186–192.PubMedGoogle Scholar
  68. 68.
    Payne CM, Nagle RB, Borduin V. Methods in laboratory investigation: an ultrastructural cytochemical stain specific for neuroendocrine neoplasms. Lab Invest 1984;51:350–365.PubMedGoogle Scholar
  69. 69.
    Nagle RB, Payne CM, Clark VA. Comparison of the usefulness of histochemistry and ultrastructural cytochemistry in the identification of neuroendocrine neoplasms. Am J Clin Pathol 1986;85:289–296.PubMedGoogle Scholar
  70. 70.
    Gould VE, Benditt EP. Ultrastructural and functional relationships of some human endocrine tumors. Pathol Annu 1973;8:205–230.PubMedGoogle Scholar
  71. 71.
    Gould VE. Neuroendocrinomas and neuroendocrine carcinomas: APUD-cell system neoplasms and their aberrant secretory activities. Pathol Annu 1977;12(pt 2):33–62.PubMedGoogle Scholar
  72. 72.
    Sunday ME, Choi N, Spindel ER, Chin WW, Mark EJ. Gastrin-releasing peptide gene expression in small cell and large cell undifferentiated carcinomas. Hum Pathol 1991;22:1030–1039.PubMedCrossRefGoogle Scholar
  73. 73.
    Hamid Q, Corrin B, Sheppard MN, Polak JM. Localization of chromogranin mRNA in small cell carcinoma of the lung. J Pathol 1991;163:293–297.PubMedCrossRefGoogle Scholar
  74. 74.
    Frohlich F. Die “Helle Zelle” der Bronchialschleimhaut and ihre Beziehungen zum Problem der Chemoreceptoren. Frankfurt Ztschr Z Pathol 19 1949;60:517–559Google Scholar
  75. 75.
    Feyrter F. Zur Pathologic des argyrophilen Helle-Zell-Organes im Bronchialbaum des Menschen. Virchows Arch 1954;325:723–732.PubMedCrossRefGoogle Scholar
  76. 76.
    Bensch KG, Gordon GB, Miller LR. Studies on the bronchial counterpart of the Kultschitzky (argentaffin) cell and innervation of bronchial glands. J Ultrastruct Res 1965;12:668–686.PubMedCrossRefGoogle Scholar
  77. 77.
    Bensch KG, Gordon GB, Miller LR. Electron microscopic and biochemical studies on the bronchial carcinoid tumor. Cancer 1965;18:592–602.PubMedCrossRefGoogle Scholar
  78. 78.
    Gmelich JT, Bensch KG, Liebow AA. Cells of Kultschitzky type in bronchioles and their relation to the origin of peripheral carcinoid tumor. Lab Invest 1967;17:88–98.PubMedGoogle Scholar
  79. 79.
    Lauweryns JM, Cokelaere M. Theunynck PK. Neuroepithelial bodies in the respiratory mucosa of various mammals: a light optical, histochemical, and ultrastructural investigation. Z Zellforsch Mikrosk Anat 1972;135:569–592.PubMedCrossRefGoogle Scholar
  80. 80.
    Lauweryns JM, Goddeeris P. Neuroepithelial bodies in the human child and adult lung. Am Rev Respir Dis 1975;111:469–476.PubMedGoogle Scholar
  81. 81.
    Johnson DE, Loch JE, Elde RP, Thompson TR. Pulmonary neuroendocrine cells in bronchopulmonary dysplasia and hyaline membrane disease. Pediatr Res 1982;16:446–454.PubMedGoogle Scholar
  82. 82.
    Johnson DE, Wobken JD, Landrum BG. Changes in bombesin, calcitonin and serotonin immunoreactive pulmonary neuroendocrine cells in cystic fibrosis and after prolonged mechanical ventilation. Am Rev Respir Dis 1988;137:123–131.PubMedGoogle Scholar
  83. 83.
    Stahlman MT, Gray ME. Ontogeny of neuroendocrine cells in human fetal lung. I. An electron microscopic study. Lab Invest 1984;51:449–463.PubMedGoogle Scholar
  84. 84.
    Stahlman MT, Kasselberg AG, Orth DN, Gray ME. Ontogeny of neuroendocrine cells in human fetal lung. II. An immunohistochemical study. Lab Invest 1985;52:52–60.PubMedGoogle Scholar
  85. 85.
    Spindel ER, Sunday ME, Hofler H, Wolfe HJ, Habener JF, Chin WW. Transient elevation of messenger RNA encoding gastrin releasing peptide, a putative pulmonary growth factor in human fetal lung. J Clin Invest 1987;80:1172–1179.PubMedCrossRefGoogle Scholar
  86. 86.
    Sobol RE, O’Connor DT, Addison J, Suchocki K, Royston I, Deftos LJ. Elevated serum chromogranin A levels in small cell lung carcinoma. Ann Intern Med 1986;1095:698–700.Google Scholar
  87. 87.
    Gosney JR, Sissons MCJ, Allibone RO, Blakely AF. Pulmonary endocrine cells in chronic bronchitis and emphysema. J Pathol 1989;157:127–133.PubMedCrossRefGoogle Scholar
  88. 88.
    Aguayo SM, King TE Jr, Waldron JA Jr, Sherritt KM, Kane MA, Miller YE. Increased pulmonary neuroendocrine cells with bombesin-like immunoreactivity in adults with eosinophilic granuloma. J Clin Invest 1989;86:838–844.CrossRefGoogle Scholar
  89. 89.
    Aguayo SM, Kane MA, King TE Jr, Schwarz MI, Graver L, Miller YE. Increased levels of bombesin-like peptides in the lower respiratory tract of asymptomatic cigarette smokers. J Clin Invest 1989;84:1105–1113.PubMedCrossRefGoogle Scholar
  90. 90.
    Tabassian AR, Nylen ES, Linnoila RI, Snider RH, Cassidy MM, Becker KL. Stimulation of hamster pulmonary neuroendocrine cells and associated peptides by repeated exposure to cigarette smoke. Am Rev Respir Dis 1989;140:436–440.PubMedGoogle Scholar
  91. 91.
    Aguayo SM, Miller YE, Waldron JA Jr, et al. Brief report: Idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells and airways disease. N Engl J Med 1992;327:1285–1288.PubMedCrossRefGoogle Scholar
  92. 92.
    Benfreld JR. Neuroendocrine neoplasms of the lung. J Thorac Cardiovasc Surg 1990;100:628–629.Google Scholar
  93. 93.
    Travis WD, Colby TV, Corrin B, et al. Histological typing of lung and pleural tumors. In collaboration with L.H. Sobin and pathologists from 14 countries. World Health Organization International Classification of Tumours. 3rd ed. Berlin, Heidelberg, New York: Springer-Verlag, 1999.Google Scholar
  94. 94.
    Travis WD, Brambilla E, Muller-Hermelink HG, Harris CC, eds. Pathology and genetics: tumours of the lung, pleura, thymus and heart. Lyon: IARC Press, 2004.Google Scholar
  95. 95.
    Whitwell F. Tumorlets of the lung. J Pathol Bacteriol 1955;70:529–541.PubMedCrossRefGoogle Scholar
  96. 96.
    Churg A, Warnock ML. Pulmonary tumorlet: A form of peripheral carcinoid. Cancer (Philadelphia) 1976;37:1469–1477.CrossRefGoogle Scholar
  97. 97.
    Miller MA, Mark J, Kanarek D. Multiple peripheral pulmonary carcinoids and tumorlets of carcinoid type, with restrictive and obstructive lung disease. Am J Med 1978;65:373–378.PubMedCrossRefGoogle Scholar
  98. 98.
    Pelosi G, Zancanaro C, Sbubo L, Bresaola E, Martignoni G, Bontempini L. Development of innumerable neuroendocrine tumorlets in pulmonary lobe scarred by intralobar sequestration: Immunohistochemical and ultrastructural study of an unusual case. Arch Pathol Lab Med 1992;116:1167–1174.PubMedGoogle Scholar
  99. 99.
    D’Aggti VD, Perzin KH. Carcinoid tumorlets of the lung with metastasis to a peribronchial lymph node: report of a case and review of the literature. Cancer (Philadelphia) 1985;55:2472–2476.CrossRefGoogle Scholar
  100. 100.
    Mueller H. Zur Untersuchungsgeschichte der bronchialen Weiterungen. Inaug Diss Halle, 1882.Google Scholar
  101. 101.
    Kramer R. Adenoma of bronchus. Ann Otol Rhinol Laryngol 1930;39:689–695.Google Scholar
  102. 102.
    Hamperl H. Uber gutartige Bronchialtumoren. Virchows Arch [Pathol Anat] 1937;300:1937:46–88.Google Scholar
  103. 103.
    Oberndorfer S. Karzinoide Tumoren des Diinndarms. Frankfurt Zeitschr Pathol 1907;1:426–432.Google Scholar
  104. 104.
    Briselli M, Mark GJ, Grillo HC. Tracheal carcinoids. Cancer (Philadelphia) 1978;42:2870–2879.CrossRefGoogle Scholar
  105. 105.
    Bonikos DS, Bensch KG, Jamplis RW. Peripheral pulmonary carcinoid tumors. Cancer (Philadelphia) 1976;37:1977–1998.CrossRefGoogle Scholar
  106. 106.
    Felton WL, Liebow AA, Lindskog GE. Peripheral and multiple bronchial adenomas. Cancer (Philadelphia) 1953;6:555–567.CrossRefGoogle Scholar
  107. 107.
    Skinner C, Ewen SWB. Carcinoid lung: diffuse pulmonary infiltration by a multifocal bronchial carcinoid. Thorax 1976;31:212–219.PubMedCrossRefGoogle Scholar
  108. 108.
    Abdi EA, Goel R, Bishop S, Bain GO. Peripheral carcinoid tumours of the lung: A clinicopathological study. J Surg Oncol 1988;39:190–196.PubMedCrossRefGoogle Scholar
  109. 109.
    Carter D, Eggleston JC, Carcinoid tumors. In: Tumors of the lower respiratory tract. Atlas of tumor pathology, 2d Ser., Fasc. 17. Washington, DC: Armed Forces Institute of Pathology, 1980:162–188.Google Scholar
  110. 110.
    Mark EJ, Quay SC, Dickensin GR. Papillary carcinoid tumor of the lung. Cancer (Philadelphia) 1981;48:316–324.CrossRefGoogle Scholar
  111. 111.
    Ranchod M, Levine GD. Spindle cell carcinoid tumors of the lung: a clinicopathologic study of 35 cases. Am J Surg Pathol 1980;4:315–331.PubMedCrossRefGoogle Scholar
  112. 112.
    Sklar JL, Churg A, Bensch KG. Oncocytic carcinoid tumor of the lung. Am J Surg Pathol 1980;4:287–292.PubMedCrossRefGoogle Scholar
  113. 113.
    Sajjad SM, Mackay B, Lukeman JM. Oncocytic carcinoid tumor of the lung. Ultrastruct Pathol 1980;1:171–176.PubMedCrossRefGoogle Scholar
  114. 114.
    Scharifker D, Marchevsky A. Oncocytic carcinoid of lung: an ultrastructural analysis. Cancer (Philadelphia) 1981;47:530–532.CrossRefGoogle Scholar
  115. 115.
    Ghadially FN, Block HJ. Oncocytic carcinoid of the lung. J Submicrosc Cytol 1985;17:435–442.PubMedGoogle Scholar
  116. 116.
    Santos-Briz, Terron J, Sastre R, Romero L, Valle A. Oncocytoma of the lung. Cancer 1977;40:1330–1336.PubMedCrossRefGoogle Scholar
  117. 117.
    Cebelin MS. Melanocytic bronchial carcinoid tumor. Cancer (Philadelphia) 1980;46:1843–1848.CrossRefGoogle Scholar
  118. 118.
    Grazer R, Cohen SM, Jacobs JB, Lucas P. Melanin-containing peripheral carcinoid of the lung. Am J Surg Pathol 1982;6:73–78.PubMedCrossRefGoogle Scholar
  119. 119.
    Carlson JA, Dickersin GR. Melanocytic paraganglioid carcinoid tumor: a case report and review of the literature. Ultrastruct Pathol 1993;17:353–372.PubMedCrossRefGoogle Scholar
  120. 120.
    Barbareschi M, Frigo B, Mosca L, et al. Bronchial carcinoids with S100 positive sustentacular cells. Pathol Res Pract 1990;186:212–217.PubMedGoogle Scholar
  121. 121.
    Capella C, Gabrielli M, Polak JM, Buffa R, Solcia E. Ultrastructural and histological study of 11 bronchial carcinoids. Virchows Arch Pathol Anat [A] 1979;381:313–329.Google Scholar
  122. 122.
    Gaffey MJ, Mills SE, Frierson HF Jr, et al. Pulmonary clear cell carcinoid tumor; another entity in the differential diagnosis of pulmonary clear cell neoplasia. Am J Surg Pathol 1998;22:1020–1025.PubMedCrossRefGoogle Scholar
  123. 123.
    Barbareschi M, Frigo B, Cristina S, Valentini L, Leonardi E, Mosca L. Bronchial carcinoid with paranuclear fibrillary inclusions related to cytokeratins and vimentin. Virchows Arch [A] Pathol Anat 1989;415:31–36.CrossRefGoogle Scholar
  124. 124.
    Arrigoni MG, Woolner LB, Bernatz PE. Atypical carcinoid tumors of the lung. J Thorac Cardiovasc Surg 1972;64:413121.Google Scholar
  125. 125.
    Leschke H. DeÜber nur regionär bösartige and über krebsig entartete Bronchusadenome bzw. Carcinoide. Virchows Arch [Path Anat] 1956;328:635–657.CrossRefGoogle Scholar
  126. 126.
    Warren WH, Memoli VA, Gould VE. Immunohistochemical and ultrastructural analysis of bronchopulmonary neuroendocrine neoplasms. II. Well-differentiated neuroendocrine carcinomas. Ultrastruct Pathol 1984;7:185–199.PubMedCrossRefGoogle Scholar
  127. 127.
    Mark EJ, Ramirez JF. Peripheral small-cell carcinoma of the lung resembling carcinoid tumor: A clinical and pathologic study of 14 cases. Arch Pathol Lab Med 1985;109:263–269.PubMedGoogle Scholar
  128. 128.
    Paladugu RR, Benfield JR, Pak HY, Ross RK, Teplitz RL. Bronchopulmonary Kulchitzky cell carcinomas. Cancer (Philadelphia) 1985;55:1303–1311.CrossRefGoogle Scholar
  129. 129.
    Tsutsumi Y, Yazaki K, Yoshioka K. Atypical carcinoid tumor of the lung, associated with giant cell transformation in bone metastases.Google Scholar
  130. 130.
    Hammar S, Bockus D, Remington F, Cooper L. The unusual spectrum of neuroendocrine lung neoplasms. Ultra Pathol 1989;13(5,6):515–560.CrossRefGoogle Scholar
  131. 131.
    Gould VE, Chejfec G. Ultrastructural and biochemical analysis of pulmonary “undifferentiated” carcinomas. Hum Pathol 1978;9:377–384.PubMedCrossRefGoogle Scholar
  132. 132.
    McDowell EM, Wilson TS, Trump BF. Atypical endocrine tumors of the lung. Arch Pathol Lab Med 1981;105:20–28.PubMedGoogle Scholar
  133. 133.
    Hammond ME, Sause WT. Large cell neuroendocrine tumors of the lung: Clinical significance and histopathologic definition. Cancer (Philadelphia) 1985;56:1624–1629.CrossRefGoogle Scholar
  134. 134.
    Neal MH, Kosinki R, Cohen P, Orenstein JM. Atypical endocrine tumors of the lung: a histologic, ultrastructural and clinical study of 19 cases. Hum Pathol 1986;17:1264–1277.PubMedCrossRefGoogle Scholar
  135. 135.
    Barbareschi M, Mariscotti C, Barberis M, Frigo B, Mosca L. Large cell neuroendocrine carcinoma of the lung. Tumori 1989;75:583–588.PubMedGoogle Scholar
  136. 136.
    Travis WD, Linnoila I, Tsokos MG, et al. Neuroendocrine tumors of the lung with proposed criteria for large cell neuroendocrine carcinoma: an ultrastructural, immunohistochemical and flow cytometric study of 35 cases. Am J Surg Pathol 1991;15:529–533.PubMedCrossRefGoogle Scholar
  137. 137.
    Wick MR, Berg LC, Hertz MI. Large cell carcinoma of the lung with neuroendocrine differentiation; a comparison with large cell “undifferentiated” pulmonary tumors. Am J Clin Pathol 1992;987:796–805.Google Scholar
  138. 138.
    Mooi WJ, Dewar A, Springall D, Polak JM, Addis BJ. Non-small cell lung carcinomas with neuroendocrine features: a light microscopic, immunohistochemical and ultrastructural study of 11 cases. Histopathology 1988;13:329–337.PubMedCrossRefGoogle Scholar
  139. 139.
    Bernard WG. The nature of the “oat-celled sarcoma” of the mediastinum. J Pathol Bacteriol 1926;29:241–244.CrossRefGoogle Scholar
  140. 140.
    Gibbon JH Jr, Nealon TF Jr. Neoplasms of the lungs and trachea. In: Gibbon JH Jr, ed. Surgery of the chest. Philadelphia: Saunders, 1962:484.Google Scholar
  141. 141.
    Kreyberg L. Histological lung cancer types. Acta Pathol Microbiol Scand [A] 1962;157(suppl):1.Google Scholar
  142. 142.
    World Health Organization. Histological typing of lung tumors. Geneva: World Health Organization, 1967.Google Scholar
  143. 143.
    The World Health Organization histological typing of lung tumors. 2d ed. Am J Clin Pathol 1982;77:123–136.Google Scholar
  144. 144.
    Hirsch FR, Matthews MJ, Aisner S, et al. Histopathologic classification of small cell lung cancer: changing concepts and terminology. Cancer 1988;62:973–977.PubMedCrossRefGoogle Scholar
  145. 145.
    Yesner R. Classification of lung-cancer histology. N Engl J Med 1985;312:652–653.PubMedGoogle Scholar
  146. 146.
    Azzopardi JG. Oat-cell carcinoma of the bronchus. J Pathol Bacteriol 1959;78:513–519.PubMedCrossRefGoogle Scholar
  147. 147.
    Yesner R. Small cell tumors of the lung. Am J Surg Pathol 1983;7:775–785.PubMedCrossRefGoogle Scholar
  148. 148.
    Carter D. Small-cell carcinoma of the lung. Am J Surg Pathol 1983;7:787–795.PubMedCrossRefGoogle Scholar
  149. 149.
    Stuart-Harris R, Boyer M, Greenberg M, Stevens S, Yung T. The histopathological classification of small cell lung cancer: application of the IASLC classification in 124 cases. Lung Cancer 1992;8:63–70.CrossRefGoogle Scholar
  150. 150.
    Gazdar AF, Carney DN, Baylin SB, et al. Small cell carcinoma of the lung. Altered morphological, biological and biochemical characteristics in long term cultures and heterotransplanted tumors. Proc Am Assoc Cancer Res 1980;21:51.Google Scholar
  151. 151.
    Fushimi H, Kihui M, Morino H, et al. Detection of large cell component in small cell lung carcinoma by combined cytologic and histologic examinations and its clinical implications. Cancer (Philadelphia) 1992;70:599–605.CrossRefGoogle Scholar
  152. 152.
    Sibley R, Rosai J, Froehlich W. A case for the panel: anemone cell tumor. Ultrastruct Pathol 1980;1:449–453.PubMedCrossRefGoogle Scholar
  153. 153.
    Sobrinho-Simoes M, Nesland JM, Johannessen JV. The mystery of the anemone cell tumor. Ultrastruct Pathol 1985;8:3–4.Google Scholar
  154. 154.
    Taxy JB, Almanasser IT. Anemone cell (villiform) tumors: electron microscopy and immunohistochemistry of five cases. Ultrastruct Pathol 1984;7:143–150.PubMedCrossRefGoogle Scholar
  155. 155.
    Wirt DP, Nagle RB, et al. The probable origin of an anemone cell tumor: metastatic transitional cell carcinoma producing HCG. Ultrastruct Pathol 1984;7:277–288.PubMedCrossRefGoogle Scholar
  156. 156.
    Osborne BM, Mackay B, Butler JJ, et al. Large cell lymphoma with microvillus-like projections: an ultrastructural study. Am J Clin Pathol 1983;79:443–450.PubMedGoogle Scholar
  157. 157.
    Phillips JI, Murray J, Verhaart S. Squamous cell carcinoma with anemone cell features. Ultrastruct Pathol 1987;11:47–52.PubMedCrossRefGoogle Scholar
  158. 158.
    Colby TV, Koss MN, Travis WD. Tumors of the lower respiratory tract. Atlas of Tumor Pathology. Washington, DC: AFIP, 1995:310–311.Google Scholar
  159. 159.
    Colby TV, Koss MN, Travis WD. Tumors of the lower respiratory tract. Atlas of Tumor Pathology. Washington, DC: AFIP, 1995:313.Google Scholar
  160. 160.
    Chejfec G, Capella C, Socia E, et al. Amphicrine cells, dysplasias and neoplasias. Cancer 1985;56:2683–2690.PubMedCrossRefGoogle Scholar
  161. 161.
    Hammar SP, Insalaco SJ, Lee RB, et al. Amphicrine carcinoma of the uterine cervix. Am J Surg Pathol 1992;97:516–522.Google Scholar
  162. 162.
    Visscher DW, Zarbo RJ, Trojanowski JQ, Sakr W, Crissman JD. Neuroendocrine differentiation in poorly-differentiated lung carcinomas: a light microscopic and immunohistologic study. Mod Pathol 1990;3:508–512.PubMedGoogle Scholar
  163. 163.
    Linnoila RI, Mulshine JL, Steinberg SM, et al. Neuroendocrine differentiation in endocrine and nonendocrine lung carcinomas. Am J Clin Pathol 1988;90:641–652.PubMedGoogle Scholar
  164. 164.
    Loy TS, Darkow GVD, Quesenberry JT. Immunostaining in the diagnosis of pulmonary neuroendocrine carcinomas: an immunohistochemical study with ultrastructural correlations. Am J Surg Pathol 1995;19:173–182.PubMedCrossRefGoogle Scholar
  165. 165.
    Schleusener JT, Tazelaar HD, Jung S, et al. Neuroendocrine differentiation is an independent prognostic factor in chemotherapy-treated non-small cell lung carcinoma. Cancer 1996;77:1284–1291.PubMedCrossRefGoogle Scholar
  166. 166.
    Jiang S, Kameya T, Shoji M, et al. Large cell neuroendocrine carcinoma of the lung: a histologic and immunohistochemical study of 22 cases. Am J Surg Pathol 1998;22:526–536.PubMedCrossRefGoogle Scholar
  167. 167.
    Lyda MH, Weiss LM. Immunoreactivity for epithelial and neuroendocrine antibodies are useful in the differential diagnosis of lung carcinomas. Hum Pathol 2000;31:980–987.PubMedCrossRefGoogle Scholar
  168. 168.
    Agoff SN, Lamps LW, Philip AT, et al. Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonary neuroendocrine tumors. Mod Pathol 2000;13:238–242.PubMedCrossRefGoogle Scholar
  169. 169.
    Cheuk W, Kwan MY, Suster S, et al. Immunostaining for thyroid transcription factor-1 and cytokeratin 20 aids in the distinction of small cell carcinoma from Merkel cell carcinoma, but not pulmonary from extrapulmonary small cell carcinomas. Arch Path Lab Med 2001;125:228–231.PubMedGoogle Scholar
  170. 170.
    Chang Y, Lee Y, Liao Y, et al. The utility and limitation of thyroid transcription factor-1 protein in primary and metastatic pulmonary neoplasms. Lung Cancer 2004;44:149–157.PubMedCrossRefGoogle Scholar
  171. 171.
    Rossi G, Marchioni A, Milani M, et al. TTF-1, cytokeratin 7, 34betaE12 and CD56/NCAM immunostaining in the subclassification of large cell carcinomas of the lung. Am J Clin Pathol 2004;122:884–893.PubMedCrossRefGoogle Scholar
  172. 172.
    Zhang H, Cagle PT, Allen TC, et al. Distinction of pulmonary small cell carcinoma from poorly differentiated squamous cell carcinoma: an immunohistochemical approach. Mod Pathol 2005;18:111–118.PubMedCrossRefGoogle Scholar
  173. 173.
    Onuki N, Wistuba II, Travis WD, et al. Genetic changes in the spectrum of neuroendocrine lung tumors. Cancer 1999;85:600–607.PubMedCrossRefGoogle Scholar
  174. 174.
    Giard L, Zochbauer-Muller S, Virmani AK, et al. Genomewide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer and loci clustering. Cancer Research 2000;60:4894–4906.Google Scholar
  175. 175.
    Hiroshima K, Iyoda A, Shibuya K, et al. Genetic alterations in early stage pulmonary large cell neuroendocrine carcinoma. Cancer 2004;100:1190–1198.PubMedCrossRefGoogle Scholar
  176. 176.
    Peng W, Sano T, Oyama T, et al. Large cell neuroendocrine carcinoma of the lung: a comparison with large cell carcinoma with neuroendocrine morphology and small cell carcinoma. Lung Cancer 2005;47:225–233.PubMedCrossRefGoogle Scholar
  177. 177.
    Vosika GJ. Large cell bronchogenic carcinoma: Prolonged disease-free survival following chemotherapy. JAMA 1979;241:594–595.PubMedCrossRefGoogle Scholar
  178. 178.
    Gibbs FA. Lymphoma versus carcinoma. JAMA 1979;242:514.PubMedCrossRefGoogle Scholar
  179. 179.
    Vosika GJ. Large cell-small cell bronchogenic carcinoma. JAMA 1979;242:1259–1260.CrossRefGoogle Scholar
  180. 180.
    Marchevsky AM, Gal AA, Shah S, et al. Morphometry confirms the presence of considerable nuclear size overlap between “small cells” and “large cells” in high-grade pulmonary neuroendocrine neoplasms. Am J Clin Pathol 2001;116:466–472.PubMedCrossRefGoogle Scholar
  181. 181.
    Travis WD, Gal AA, Colby TV, et al. Reproducibility of neuroendocrine lung tumor classification. Hum Pathol 1998;29:272–279.PubMedCrossRefGoogle Scholar
  182. 182.
    Lin O, Olgac S, Green I, et al. Immunohistochemical staining of cytologic smears with MIB-1 helps distinguish lowgrade from high-grade neuroendocrine neoplasms. Am J Clin Pathol 2003;120:209–216.PubMedCrossRefGoogle Scholar
  183. 183.
    Pelosi G, Rodriguez J, Viale G, et al. Typical and atypical carcinoid tumor overdiagnosed as small cell carcinoma on biopsy specimens: a major pitfall in the management of lung cancer patients. Am J Surg Pathol 2005;29:179–187.PubMedCrossRefGoogle Scholar
  184. 184.
    Brambilla E. Basaloid carcinoma of the lung. In: Corrin B, ed. Pathology of lung tumors. New York: Churchill-Livingstone, 1997;71–82.Google Scholar
  185. 185.
    vanHengel P, vanGeffen F, Kazzaz BA, Heyerman HG. Atypical carcinoid presenting as mesothelioma. Neth J Med 2001;58:185–190.CrossRefGoogle Scholar
  186. 186.
    Falconieri G, Zanconati F, Bossani R, DiBonito L. Small cell carcinoma of lung simulating pleural mesothelioma: report of 4 cases with autopsy confirmation. Path Res Pract 1995;191:1147–1152.PubMedGoogle Scholar
  187. 187.
    Hammar SP, Robb JA, Yokoo H, Dodson RF, Henderson D. Pseudomesotheliomatous lung cancer: a neoplasm frequently associated with asbestos exposure. (Submitted for publication).Google Scholar
  188. 188.
    Hurlimann J. Desmin and neural marker expression in mesothelial cells and mesotheliomas. Hum Pathol 1994;25:753–757.PubMedCrossRefGoogle Scholar
  189. 189.
    Chute CG, Greenberg ER, Baron J, Korson R, Baker J, Yates J. Presenting conditions of 1539 population-based lung cancer patients by cell type and stage in New Hampshire and Vermont. Cancer (Philadelphia) 1985;56:2107–2111.CrossRefGoogle Scholar
  190. 190.
    Andersen HA, Bernatz PE. Extrathoracic manifestations of bronchogenic carcinoma. Med Clin North Am 1964;48:921–931.PubMedGoogle Scholar
  191. 191.
    Mountain CF, Lukeman JM, Hammar S, et al. Lung cancer classification: the relationship of disease extent and cell type to survival in a trial population. J Surg Oncol 1987;35:147–156.PubMedCrossRefGoogle Scholar
  192. 192.
    Feld R, Rubinstein LV, Weisenberger TH, and the Lung Cancer Study Group. Sites of resected stage 1 non-small cell lung cancer: a guide for future studies. J Clin Oncol 1984;2:1352–1358.PubMedGoogle Scholar
  193. 193.
    Li W, Hammar SP, Jolly PC, et al. Unpredictable course of small cell undifferentiated lung carcinoma. J Thorac Cardiovasc Surg 1981;81:34–43.PubMedGoogle Scholar
  194. 194.
    Okike N, Bernatz PE, Woolner LB. Carcinoid tumors of the lung. Ann Thorac Surg 1976;22:270–275.PubMedCrossRefGoogle Scholar
  195. 195.
    Brandt B, Heintz SE, Rose EF, Ehrenhaft JL. Bronchial carcinoid tumors. Ann Thorac Surg 1984;38:63–65.PubMedCrossRefGoogle Scholar
  196. 196.
    McCaughan BC, Martini N, Bains MS. Bronchial carcinoids: review of 124 cases. J Thorac Cardiovasc Surg 1985;89:8–17.PubMedGoogle Scholar
  197. 197.
    Thunnissen FBJM, van Eijk J, Baak JPA, et al. Bronchopulmonary carcinoids and regional node metastases: a quantitative pathologic investigation. Am J Pathol 1988;132:119–122.PubMedGoogle Scholar
  198. 198.
    Warren WH, Gould VE. Long-term follow-up of classical bronchial carcinoid tumors. Scand J Thor Cardiovase Surg 1990;24:125–130.Google Scholar
  199. 199.
    El-Naggar A, Ballance W, Abdul-Karim FW, et al. Typical and atypical bronchopulmonary carcinoids: a clinicopathologic and flow cytometric study. Am J Clin Pathol 1991;95:828–834.PubMedGoogle Scholar
  200. 200.
    Yousem SA, Taylor SR. Typical and atypical carcinoid tumors of lung: a clinicopathologic and DNA analysis of 20 tumors. Mod Pathol 1990;3:502–507.PubMedGoogle Scholar
  201. 201.
    Bernstein C, McGoey J, Lertzman M. Recurrent bronchial carcinoid tumor. Chest 1989;95:693–694.PubMedCrossRefGoogle Scholar
  202. 202.
    Greengard O, Head JF, Goldberg SI, Kirschner PA. Pulmonary carcinoid tumors: enzymic discriminants, growth rate and early age of inception. Cancer Res 1986;46:2600–2605.PubMedGoogle Scholar
  203. 203.
    Vadasz P, Palffy G, Egervary M, Schaff Z. Diagnosis and treatment of bronchial carcinoid tumors: clinical and pathological review of 120 operated patients. Eur J Cardiothorac Surg 1993;7:8–11.PubMedCrossRefGoogle Scholar
  204. 204.
    Ducrocq X, Thomas P, Massard G, et al. Operative risk and prognostic factors of typical bronchial carcinoid tumors. Ann Thorac Surg 1998;65:1410–1414.PubMedCrossRefGoogle Scholar
  205. 205.
    Slodkowska J, Langfort R, Rudzinski P, Kupis W. Typical and atypical carcinoids—pathologic and clinical analysis of 77 cases. Pneumonol Alergol Pol 1998;66:297–303.PubMedGoogle Scholar
  206. 206.
    Travis WD, Rush W, Flieder DB, et al. Survival analysis of 200 pulmonary neuroendocrine tumors with clarification of criteria for atypical carcinoid and its separation from typical carcinoid. Am J Surg Pathol 1998;22:934–944.PubMedCrossRefGoogle Scholar
  207. 207.
    Thomas CF Jr., Tazelaar HD, Jett JR. Typical and atypical pulmonary carcinoids: outcome in patients presenting with regional lymph node involvement. Chest 2001;119:1143–1150.PubMedCrossRefGoogle Scholar
  208. 208.
    Fink G, Krelbaum T, Yellin A, et al. Pulmonary carcinoid: presentation, diagnosis and outcome in 142 cases in Israel and review of 640 cases from the literature. Chest 2001;119:1647–1651.PubMedCrossRefGoogle Scholar
  209. 209.
    Schmid K, Birner P, Gravenhorst V, et al. Prognostic value of lymphatic and blood vessel invasion in neuroendocrine tumors of the lung. Am J Surg Pathol 2005;29:324–328.PubMedCrossRefGoogle Scholar
  210. 210.
    Yousem SA. Pulmonary carcinoid tumors and well differentiated neuroendocrine carcinomas: Is there room for atypical carcinoid? Am J Cln Pathol 1991;95:828–834.Google Scholar
  211. 211.
    Warren WH, Memoli VA, Jordan AG, Gould VE. Reevaluation of pulmonary neoplasms as small cell neuroendocrine carcinomas. Cancer 1990;65:1003–1010.PubMedCrossRefGoogle Scholar
  212. 212.
    Larsimont D, Kiss R, deLaunoit Y, Melamed MR. Characterization of the morphonuclear features and DNA ploidy of typical and atypical carcinoids and small cell carcinomas of the lung. Am J Clin Pathol 1990;94:378–373.PubMedGoogle Scholar
  213. 213.
    Lequaglie C, Patriarca C, Cataldo I, Muscolino G, Preda F, Ravasi G. Prognosis of resected well-differentiated neuroendocrine carcinoma of the lung. Chest 1991;100:1053–1056.PubMedCrossRefGoogle Scholar
  214. 214.
    Memoli VA. Well-differentiated neuroendocrine carcinoma: a designation comes of age. Chest 1991;100:892.PubMedCrossRefGoogle Scholar
  215. 215.
    Jackson-York GL, Davis GH, Warren WH, Gould VE, Memoli VA. Flow cytometric DNA content analysis in neuroendocrine carcinoma of the lung: correlation with survival and histologic subtype. Cancer (Philadelphia) 1991;68:374–379.CrossRefGoogle Scholar
  216. 216.
    Jung KJ, Lee KS, Han J, et al. Large cell neuroendocrine carcinoma of the lung: clinical, CT and pathologic findings in 11 patients. J Thorac Imaging 2001;16:156–162.PubMedCrossRefGoogle Scholar
  217. 217.
    Mazieres J, Daste G, Molinier L, et al. Large cell neuroendocrine carcinoma of the lung: pathological study and clinical outcome of 18 resected cases. Lung Cancer 2002;37:287–292.PubMedCrossRefGoogle Scholar
  218. 218.
    Paci M, Cavazza A, Annessi V, et al. Large cell neuroendocrine carcinoma of the lung: a 10-year clinicopathologic retrospective study. Ann Thorac Surg 2004;77:1163–1167.PubMedCrossRefGoogle Scholar
  219. 219.
    Doddoli C, Barlesi F, Chetaille B, et al. Large cell neuroendocrine carcinoma of the lung: an aggressive disease potentially treatable with surgery. Ann Thorac Surg 2004;77:1168–1172.PubMedCrossRefGoogle Scholar
  220. 220.
    Quoix E, Fraser R, Wolkove N, Finkelstein H, Kreisman H. Small cell lung cancer presenting as a solitary pulmonary nodule. Cancer (Philadelphia) 1990;66:577–582.CrossRefGoogle Scholar
  221. 221.
    Kreisman H, Wolkove N, Quoix E. Small cell lung cancer presenting as a solitary pulmonary nodule. Chest 1992;101:225–229.PubMedCrossRefGoogle Scholar
  222. 222.
    Shepherd FA, Ginsberg R, Evans WK, Haddad R, Feld R, DeBoer G. “Very limited” small cell lung cancer: Results of nonsurgical treatment. Proc Am Soc Clin Oncol 1984;3:223–228.Google Scholar
  223. 223.
    Gephardt GN, Grady KJ, Ahmad M, Tubbs RR, Mehta AC, Shepard KV. Peripheral small cell undifferentiated carcinoma of the lung: clinicopathologic features of 17 cases. Cancer (Philadelphia) 1988;61:1002–1008.CrossRefGoogle Scholar
  224. 224.
    Fraire AE, Johnson EH, Yesner R, Zhang XB, Spjut HJ, Greenberg SD. Prognostic significance of histopathologic subtype and stage in small cell lung cancer. Hum Pathol 1992;23:520–528.PubMedCrossRefGoogle Scholar
  225. 225.
    Bepler G, Neumann K, Holle R, Havemann K, Kalbfleisch H. Clinical relevance of histologic subtyping in small cell lung cancer. Cancer (Philadelphia) 1989;64:74–79.CrossRefGoogle Scholar
  226. 226.
    Crown JPA, Chahinian AP, Jaffrey IS, Glidewell OJ, Kaneko M, Holland JR. Predictors of 5-year survival and curability in small cell lung cancer. Cancer (Philadelphia) 1990;66:382–386.CrossRefGoogle Scholar
  227. 227.
    Albain KS, Crowley JJ, Livingston RB. Long-term survival and toxicity in small cell lung cancer: Expanded Southwest Oncology Group experience. Chest 1991;99:1425–1432.PubMedCrossRefGoogle Scholar
  228. 228.
    Oud PS, Pahlplatz MM, Beck LM, Wiersma-Van Tilburg A, Wagenaar SJ, Vooijs GP. Image and flow DNA cytometry of small cell carernoma of the lung. Cancer (Philadelphia) 1989;64:1304–1309.CrossRefGoogle Scholar
  229. 229.
    Funa K, Steinholtz L, Nov E, Bergh J. Increased expression of N-myc in human small cell lung cancer biopsies predicts lack of response to chemotherapy. Am J Clin Pathol 1987;88:216–220.PubMedGoogle Scholar
  230. 230.
    Copple B, Wright SE, Moatamed F. Electron microscopy in small cell lung carcinomas: clinical correlation. J Clin Oncol 1984;2:910–916.PubMedGoogle Scholar
  231. 231.
    Vollmer RT, Shelburne JD, Iglehart JD. Intercellular junctions and tumor stage in small cell carcinoma of the lung. Hum Pathol 1986;18:22–27.CrossRefGoogle Scholar
  232. 232.
    Nicholson SA, Beasley MB, Brambilla E, et al. Small cell lung carcinoma (SCLC): a clinicopathologic study of 100 cases with surgical specimens. Am J Surg Pathol 2002;26:1184–1197.PubMedCrossRefGoogle Scholar
  233. 233.
    Garcia-Yuste M, Matilla JM, Alvarez-Gago T, et al. Prognostic factors in neuroendocrine lung tumors: a Spanish Multicenter Study. Ann Thorac Surg 2000;70:258–263.PubMedCrossRefGoogle Scholar
  234. 234.
    Huang Q, Muzitansky A, Mark EJ. Pulmonary neuroendocrine carcinomas: a review of 234 cases and a statistical analysis of 50 cases treated at one institution using a simple clinicopathologic classification. Arch Pathol Lab Med 2002;126:545–553.PubMedGoogle Scholar
  235. 235.
    Skuladottir H, Hirsch FR, Hansen HH, Olsen JH. Pulmonary neuroendocrine tumors: incidence and prognosis of histological subtypes. A population-based study in Denmark. Lung Cancer 2002;37:127–135.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Samuel P. Hammar
    • 1
  1. 1.Pathology Associates of Kitsap CountyHarrison Medical CenterBremertonUSA

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