Cytopathology of Pulmonary Neoplasia

  • N. Paul Ohori
  • Elise R. Hoff


Cytopathologic techniques have the potential to provide useful diagnostic information from specimens obtained through minimally invasive procedures including expectorated sputum, washings, lavages, brushings, and aspiration procedures. These procedures provide access to almost any site within the thorax. Given optimal conditions, many neoplasms can be diagnosed by cytology procedures. However, it is important to understand the strengths and limitations of cytopathologic evaluation. While pulmonary neoplastic classification is relatively stable, recent histopathologic, immunohistochemical, and molecular studies underscore the complexity of neoplasms. Cytologic sampling may be representative of the entire tumor or may represent the “tip of the iceberg.” An understanding of biologic complexity of pulmonary neoplasms helps to avoid overdiagnosing an entity. To provide an ideal cytopathologic diagnosis and report that accurately reflect the entire process, the pathologist should take a number of steps.


Bronchioloalveolar Carcinoma Large Cell Neuroendocrine Carcinoma Chromatin Pattern Sclerosing Hemangioma Pulmonary Sclerosing Hemangioma 
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© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • N. Paul Ohori
    • 1
  • Elise R. Hoff
    • 1
  1. 1.Department of PathologyUniversity of Pittsburgh Medical Center—PresbyterianPittsburghUSA

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