Lymphoproliferative Diseases

  • William George Morice
  • Thomas V. Colby


Lymphoreticular diseases affecting the lung include primary and secondary lymphomas and related disorders, leukemias, and a number of lesions that are generally considered benign and hyperplastic processes. Distinguishing neoplastic disorders such as low-grade B-cell lymphomas from reactive conditions associated with prominent lymphoid infiltrates such as lymphocytic interstitial pneumonia has long been difficult for pathologists.1, 2, 3, 4 This difficulty is typified by the colorful history of pseudolymphoma (see below) and by lymphomatoid granulomatosis, with all its synonyms,5, 6, 7 which has been considered by some to be a peculiar vasculitis and by others a lymphoproliferative disorder, although the weight of evidence suggests that most cases represent the latter.8


Anaplastic Lymphoma Kinase Malt Lymphoma Lymphatic Route Follicular Dendritic Cell Sarcoma Pulmonary Malt Lymphoma 


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  1. 1.
    Greenberg SD, Heisler JG, Gyorkey F, Jenkins DE. Pulmonary lymphoma versus pseudolymphoma: a perplexing problem. South Med J 1972;65:775–784.PubMedGoogle Scholar
  2. 2.
    Julsrud PR, Brown LR, Li CY, Rosenow EC 3rd, Crowe JK. Pulmonary processes of mature-appearing lymphocytes: pseudolymphoma, well-differentiated lymphocytic lymphoma, and lymphocytic interstitial pneumonitis. Radiology 1978;127:289–296.PubMedGoogle Scholar
  3. 3.
    Liebow AA, Carrington CR, Friedman PJ. Lymphomatoid granulomatosis. Hum Pathol 1972;3:457–558.PubMedCrossRefGoogle Scholar
  4. 4.
    Liebow AA, Carrington CB. Diffuse pulmonary lymphoreticular infiltrations associated with dysproteinemia. Med Clin North Am 1973;57:809–843.PubMedGoogle Scholar
  5. 5.
    Lipford EH Jr, Margolick JB, Longo DL, Fauci AS, Jaffe ES. Angiocentric immunoproliferative lesions: a clinicopathologic spectrum of post-thymic T-cell proliferations. Blood 1988;72:1674–1681.PubMedGoogle Scholar
  6. 6.
    DeRemee RA, Weiland LH, McDonald TJ. Polymorphic reticulosis, lymphomatoid granulomatosis. Two diseases or one? Mayo Clin Proc 1978;53:634–640.PubMedGoogle Scholar
  7. 7.
    Saldana MJ, Patchefsky AS, Israel HI, Atkinson GW. Pulmonary angiitis and granulomatosis. The relationship between histological features, organ involvement, and response to treatment. Hum Pathol 1977;8:391–409.PubMedCrossRefGoogle Scholar
  8. 8.
    Jaffe ES, Wilson WH. Lymphomatoid granulomatosis: pathogenesis, pathology and clinical implications. Cancer Surv 1997;30:233–248.PubMedGoogle Scholar
  9. 9.
    Jaffe ES, Harris NL, Stein H, Vardiman JW. World Health Organization classification of tumours. In: Kleihues P, Sobin L, eds. Pathology and genetics of tumours of haemotopoietic and lymphoid tissues. Lyon: IARC Press, 2001.Google Scholar
  10. 10.
    Okada Y. Lymphatic system of the human lung. Kyoto: Kinpodo, 1989.Google Scholar
  11. 11.
    Nagaishi C. Functional anatomy and histology of the lung. Baltimore: University Park, 1972.Google Scholar
  12. 12.
    Sykes AM, Swensen SJ, Tazelaar HD, Jung SH. Computed tomography of benign intrapulmonary lymph nodes: retrospective comparison with sarcoma metastases. Mayo Clin Proc 2002;77:329–333.PubMedCrossRefGoogle Scholar
  13. 13.
    Kradin RL, Spirn PW, Mark EJ. Intrapulmonary lymph nodes. Clinical, radiologic, and pathologic features. Chest 1985;87:662–667.PubMedCrossRefGoogle Scholar
  14. 14.
    Swensen SJ, Jett JR, Hartman TE, et al. Lung cancer screening with CT: Mayo Clinic experience [see comment]. Radiology 2003;226:756–761.PubMedCrossRefGoogle Scholar
  15. 15.
    Bienenstock J, Johnston N, Perey DY. Bronchial lymphoid tissue. I. Morphologic characteristics. Lab Invest 1973;28:686–692.PubMedGoogle Scholar
  16. 16.
    Bienenstock J, Johnston N, Perey DY. Bronchial lymphoid tissue. II. Functional characteristics. Lab Invest 1973;28:693–698.PubMedGoogle Scholar
  17. 17.
    Bienenstock J. The lung as an immunologic organ. Annu Rev Med 1984;35:49–62.PubMedCrossRefGoogle Scholar
  18. 18.
    Bienenstock J, Befus D. Gut-and bronchus-associated lymphoid tissue. Am J Anat 1984;170:437–445.PubMedCrossRefGoogle Scholar
  19. 19.
    Pabst R, Gehrke I. Is the bronchus-associated lymphoid tissue (BALT) an integral structure of the lung in normal mammals, including humans? Am J Respir Cell Mol Biol 1990;3:131–135.PubMedGoogle Scholar
  20. 20.
    Harris NL. Extranodal lymphoid infiltrates and mucosaassociated lymphoid tissue (MALT). A unifying concept. [see comment]. Am J Surg Pathol 1991;15:879–884.PubMedGoogle Scholar
  21. 21.
    Isaacson PG, Spencer J. Malignant lymphoma of mucosa-associated lymphoid tissue. Histopathology 1987;11:445–462.PubMedCrossRefGoogle Scholar
  22. 22.
    Addis BJ, Hyjek E, Isaacson PG. Primary pulmonary lymphoma: a re-appraisal of its histogenesis and its rela — tionship to pseudolymphoma and lymphoid interstitial pneumonia. Histopathology 1988;13:1–17.PubMedCrossRefGoogle Scholar
  23. 23.
    Isaacson P, Wright DH. Extranodal malignant lymphoma arising from mucosa-associated lymphoid tissue. Cancer 1984;53:2515–2524.PubMedCrossRefGoogle Scholar
  24. 24.
    Hernandez JA, Sheehan WW. Lymphomas of the mucosaassociated lymphoid tissue. Signet ring cell lymphomas presenting in mucosal lymphoid organs. Cancer 1985;55:592–597.PubMedCrossRefGoogle Scholar
  25. 25.
    Morris H, Edwards J, Tiltman A, Emms M. Endometrial lymphoid tissue: an immunohistological study. J Clin Pathol 1985;38:644–652.PubMedCrossRefGoogle Scholar
  26. 26.
    Balikian JP, Herman PG. Non-Hodgkin lymphoma of the lungs. Radiology 1979;132:569–576.PubMedGoogle Scholar
  27. 27.
    Bragg DG. The clinical, pathologic and radiographic spectrum of the intrathoracic lymphomas. Invest Radiol 1978;13:2–11.PubMedCrossRefGoogle Scholar
  28. 28.
    Blank N, Castellino RA. The intrathoracic manifestations of the malignant lymphomas and the leukemias. Semin Roentgenol 1980;15:227–245.PubMedCrossRefGoogle Scholar
  29. 29.
    Lee KS, Kim Y, Primack SL. Imaging of pulmonary lymphomas. AJR Am J Roentgenol 1997;168:339–345.PubMedGoogle Scholar
  30. 30.
    Wislez M, Cadranel J, Antoine M, et al. Lymphoma of pulmonary mucosa-associated lymphoid tissue: CT scan findings and pathological correlations. Eur Respir J 1999;14:423–429.PubMedCrossRefGoogle Scholar
  31. 31.
    Yousem SA, Colby TV, Carrington CB. Follicular bronchitis/bronchiolitis. Hum Pathol 1985;16:700–706.PubMedCrossRefGoogle Scholar
  32. 32.
    Sue-Chu M, Karjalainen EM, Altraja A, et al. Lymphoid aggregates in endobronchial biopsies from young elite cross-country skiers. Am J Respir Crit Care Med 1998;158:597–601.PubMedGoogle Scholar
  33. 33.
    Meuwissen HJ, Hussain M. Bronchus-associated lymphoid tissue in human lung: correlation of hyperplasia with chronic pulmonary disease. Clin Immunol Immunopathol 1982;23:548–561.PubMedCrossRefGoogle Scholar
  34. 34.
    Yousem SA, Colby TV, Carrington CB. Lung biopsy in rheumatoid arthritis. Am Rev Respir Dis 1985;131:770–777.PubMedGoogle Scholar
  35. 35.
    Kradin RL, Mark EJ. Benign lymphoid disorders of the lung, with a theory regarding their development. Hum Pathol 1983;14:857–867.PubMedCrossRefGoogle Scholar
  36. 36.
    Grieco MH, Chinoy-Acharya P. Lymphocytic inter — stitial pneumonia associated with the acquired immune deficiency syndrome. Am Rev Respir Dis 1985;131:952–955.PubMedGoogle Scholar
  37. 37.
    Dorfman RF, Warnke R. Lymphadenopathy simulating the malignant lymphomas. Hum Pathol 1974;5:519–550.PubMedCrossRefGoogle Scholar
  38. 38.
    Frizzera G, Moran EM, Rappaport H. Angio-immunoblastic lymphadenopathy. Diagnosis and clinical course. Am J Med 1975;59:803–818.PubMedCrossRefGoogle Scholar
  39. 39.
    Iseman MD, Schwarz MI, Stanford RE. Interstitial pneumonia in angio-immunoblastic lymphadenopathy with dysproteinemia. A case report with special histopathologic studies. Ann Intern Med 1976;85:752–755.PubMedGoogle Scholar
  40. 40.
    Zylak CJ, Banerjee R, Galbraith PA, McCarthy DS. Lung involvement in angioimmunoblastic lymphadenopathy (ail). Radiology 1976;121:513–519.PubMedGoogle Scholar
  41. 41.
    Weisenburger D, Armitage J, Dick F. Immunoblastic lymphadenopathy with pulmonary infiltrates, hypocomplementemia and vasculitis. A hyperimmune syndrome. Am J Med 1977;63:849–854.PubMedCrossRefGoogle Scholar
  42. 42.
    Dogan A, Attygalle AD, Kyriakou C. Angioimmunoblastic T-cell lymphoma. Br J Haematol 2003;121:681–691.PubMedCrossRefGoogle Scholar
  43. 43.
    Koss MN, Hochholzer L, Langloss JM, Wehunt WD, Lazarus AA. Lymphoid interstitial pneumonia: clinicopathological and immunopathological findings in 18 cases. Pathology 1987;19:178–185.PubMedCrossRefGoogle Scholar
  44. 44.
    Strimlan CV, Rosenow EC 3rd, Weiland LH, Brown LR. Lymphocytic interstitial pneumonitis. Review of 13 cases. Ann Intern Med 1978;88:616–621.PubMedGoogle Scholar
  45. 45.
    American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med 2002;165:277–304.Google Scholar
  46. 46.
    Church JA, Isaacs H, Saxon A, Keens TG, Richards W. Lymphoid interstitial pneumonitis and hypogammaglobulinemia in children. Am Rev Respir Dis 1981;124:491–496.PubMedGoogle Scholar
  47. 47.
    Perreault C, Cousineau S, D’Angelo G, et al. Lymphoid interstitial pneumonia after allogeneic bone marrow transplantation. A possible manifestation of chronic graftversus-host disease. Cancer 1985;55:1–9.PubMedCrossRefGoogle Scholar
  48. 48.
    Yoshizawa Y, Ohdama S, Ikeda A, Ohtsuka M, Masuda S, Tanaka M. Lymphoid interstitial pneumonia associated with depressed cellular immunity and polyclonal gammopathy. Am Rev Respir Dis 1984;130:507–509.PubMedGoogle Scholar
  49. 49.
    Dukes RJ, Rosenow EC 3rd, Hermans PE. Pulmonary manifestations of hypogammaglobulinaemia. Thorax 1978;33:603–607.PubMedCrossRefGoogle Scholar
  50. 50.
    Solal-Celigny P, Couderc LJ, Herman D, et al. Lymphoid interstitial pneumonitis in acquired immunodeficiency syndrome-related complex. Am Rev Respir Dis 1985;131:956–960.PubMedGoogle Scholar
  51. 51.
    Khardori R, Eagleton LE, Soler NG, McConnachie PR. Lymphocytic interstitial pneumonitis in autoimmune thyroid disease. Am J Med 1991;90:649–652.PubMedGoogle Scholar
  52. 52.
    Kohler PF, Cook RD, Brown WR, Manguso RL. Common variable hypogammaglobulinemia with T-cell nodular lymphoid interstitial pneumonitis and B-cell nodular lymphoid hyperplasia: different lymphocyte populations with a similar response to prednisone therapy. J Allerg Clin Immunol 1982;70:299–305.CrossRefGoogle Scholar
  53. 53.
    Colby TV, Carrington CB. Lymphoreticular tumors and infiltrates of the lung. Pathol Annu 1983;18 (pt 1):27–70.PubMedGoogle Scholar
  54. 54.
    Turner RR, Colby TV, Doggett RS. Well-differentiated lymphocytic lymphoma. A study of 47 patients with primary manifestation in the lung. Cancer 1984;54:2088–2096.PubMedCrossRefGoogle Scholar
  55. 55.
    Nicholson AG, Wotherspoon AC, Diss TC, et al. Reactive pulmonary lymphoid disorders. Histopathology 1995;26:405–412.PubMedCrossRefGoogle Scholar
  56. 56.
    Koss MN, Hochholzer L, Nichols PW, Wehunt WD, Lazarus AA. Primary non-Hodgkin’s lymphoma and pseudolymphoma of lung: a study of 161 patients. Hum Pathol 1983;14:1024–1038.PubMedCrossRefGoogle Scholar
  57. 57.
    Li G, Hansmann ML, Zwingers T, Lennert K. Primary lymphomas of the lung: morphological, immunohistochemical and clinical features. Histopathology 1990;16:519–531.PubMedCrossRefGoogle Scholar
  58. 58.
    L’Hoste RJ Jr, Filippa DA, Lieberman PH, Bretsky S. Primary pulmonary lymphomas. A clinicopathologic analysis of 36 cases. Cancer 1984;54:1397–1406.PubMedCrossRefGoogle Scholar
  59. 59.
    Kennedy JL, Nathwani BN, Burke JS, Hill LR, Rappaport H. Pulmonary lymphomas and other pulmonary lymphoid lesions. A clinicopathologic and immunologic study of 64 patients. Cancer 1985;56:539–552.PubMedCrossRefGoogle Scholar
  60. 60.
    Herbert A, Wright DH, Isaacson PG, Smith JL. Primary malignant lymphoma of the lung: histopathologic and immunologic evaluation of nine cases. Hum Pathol 1984;15:415–422.PubMedCrossRefGoogle Scholar
  61. 61.
    Weiss LM, Yousem SA, Warnke RA. Non-Hodgkin’s lymphomas of the lung. A study of 19 cases emphasizing the utility of frozen section immunologic studies in differential diagnosis. Am J Surg Pathol 1985;9:480–390.PubMedCrossRefGoogle Scholar
  62. 62.
    Saltzstein S. Pulmonary malignant lymphomas and pseudolymphomas: Classification, therapy, and prognosis. Cancer 1963;16:928–955.PubMedCrossRefGoogle Scholar
  63. 63.
    Colby TV, Lombard C, Yousem SA, Kitaichi M. Atlas of pulmonary surgical pathology. Philadelphia: WB Saunders, 1991.Google Scholar
  64. 64.
    Keller AR, Hochholzer L, Castleman B. Hyaline-vascular and plasma-cell types of giant lymph node hyperplasia of the mediastinum and other locations. Cancer 1972;29:670–683.PubMedCrossRefGoogle Scholar
  65. 65.
    Papaioannou AN, Watson WL. Primary lymphoma of the lung: an appraisal of its natural history and a comparison with other localized lymphoma. J Thorac Cardiovasc Surg 1965;49:373–387.PubMedGoogle Scholar
  66. 66.
    Colby TV, Carrington CB. Pulmonary lymphomas simulating lymphomatoid granulomatosis. Am J Surg Pathol 1982;6:19–32.PubMedCrossRefGoogle Scholar
  67. 67.
    Saltzstein S. Extranodal malignant lymphomas and pseudolymphomas. Pathol Annu 1969;4:159–184.Google Scholar
  68. 68.
    Kurtin PJ, Hobday KS, Ziesmer S, Caron BL. Demonstration of distinct antigenic profiles of small B-cell lymphomas by paraffin section immunohistochemistry. Am J Clin Pathol 1999;112:319–329.PubMedGoogle Scholar
  69. 69.
    Fiche M, Caprons F, Berger F, et al. Primary pulmonary non-Hodgkin’s lymphomas. Histopathology 1995;26:529–537.PubMedCrossRefGoogle Scholar
  70. 70.
    Cordier JF, Chailleux E, Lauque D, et al. Primary pulmonary lymphomas. A clinical study of 70 cases in nonimmunocompromised patients. Chest 1993;103:201–208.PubMedCrossRefGoogle Scholar
  71. 71.
    Kurtin PJ, Myers JL, Adlakha H, et al. Pathologic and clinical features of primary pulmonary extranodal marginal zone B-cell lymphoma of MALT type. Am J Surg Pathol 2001;25:997–1008.PubMedCrossRefGoogle Scholar
  72. 72.
    Winterbauer RH, Riggins RC, Griesman FA, Bauermeister DE. Pleuropulmonary manifestations of Waldenstrom’s macroglobulinemia. Chest 1974;66:368–375.PubMedCrossRefGoogle Scholar
  73. 73.
    Essig LJ, Timms ES, Hancock DE, Sharp GC. Plasma cell interstitial pneumonia and macroglobulinemia. A response to corticosteroid and cyclophosphamide therapy. Am J Med 1974;56:398–405.PubMedCrossRefGoogle Scholar
  74. 74.
    Case records of the Massachusetts General Hospital, Case 43-1982. N Engl J Med 1982;307:1065–1073.Google Scholar
  75. 75.
    Isaacson PG, Wotherspoon AC, Diss T, Pan LX. Follicular colonization in B-cell lymphoma of mucosa-associated lymphoid tissue. Am J Surg Pathol 1991;15:819–828.PubMedCrossRefGoogle Scholar
  76. 76.
    Khoor A, Myers JL, Tazelaar HD, Kurtin PJ. Amyloid-like pulmonary nodules, including localized light-chain deposition: clinicopathologic analysis of three cases. Am J Clin Pathol 2004;121:200–204.PubMedCrossRefGoogle Scholar
  77. 77.
    Lim JK, Lacy MQ, Kurtin PJ, Kyle RA, Gertz MA. Pulmonary marginal zone lymphoma of MALT type as a cause of localised pulmonary amyloidosis. J Clin Pathol 2001;54:642–646.PubMedCrossRefGoogle Scholar
  78. 78.
    Sun Y, Tawfiqul B, Valderrama E, Kline G, Kahn LB. Pulmonary crystal-storing histiocytosis and extranodal marginal zone B-cell lymphoma associated with a fibroleiomyomatous hamartoma. Ann Diagn Pathol 2003;7:47–53.PubMedCrossRefGoogle Scholar
  79. 79.
    Suarez P, el-Naggar AK, Batsakis JG. Intracellular crystalline deposits in lymphoplasmacellular disorders. Ann Otol Rhinol Laryngol 1997;106:170–172.PubMedGoogle Scholar
  80. 80.
    Fend F, Gabl C, Hittmair A, Greil R, Feichtinger H. Gastric malt lymphoma with crystalline immunoglobulin inclusions and secondary immunoblastic lymphoma in a cervical lymph node. [see comment]. Pathol Res Pract 1995;191:1053–1058.PubMedGoogle Scholar
  81. 81.
    Murga Penas EM, Hinz K, Roser K, et al. Translocations t(11;18)(q21;q21) and t(14;18)(q32;q21) are the main chromosomal abnormalities involving MLT/MALT1 in MALT lymphomas. Leukemia 2003;17:2225–2229.PubMedCrossRefGoogle Scholar
  82. 82.
    Cavalli F, Isaacson PG, Gascoyne RD, Zucca E. MALT Lymphomas. Hematology 2001:241–258.Google Scholar
  83. 83.
    Wotherspoon AC, Finn TM, Isaacson PG. Trisomy 3 in lowgrade B-cell lymphomas of mucosa-associated lymphoid tissue. Blood 1995;85:2000–2004.PubMedGoogle Scholar
  84. 84.
    Remstein ED, Kurtin PJ, James CD, Wang XY, Meyer RG, Dewald GW. Mucosa-associated lymphoid tissue lymphomas with t(11;18)(q21;q21) and mucosa-associated lymphoid tissue lymphomas with aneuploidy develop along different pathogenetic pathways. Am J Pathol 2002;161:63–71.PubMedGoogle Scholar
  85. 85.
    Ott G, Katzenberger T, Greiner A, et al. The t(11;18) (q21;q21) chromosome translocation is a frequent and specific aberration in low-grade but not high-grade malignant non-Hodgkin’s lymphomas of the mucosa-associated lymphoid tissue (MALT-) type. Cancer Res 1997;57:3944–3948.PubMedGoogle Scholar
  86. 86.
    Auer IA, Gascoyne RD, Connors JM, et al. t(11;18) (q21;q21) is the most common translocation in MALT lymphomas. Ann Oncol 1997;8:979–985.PubMedCrossRefGoogle Scholar
  87. 87.
    Remstein ED, Kurtin PJ, Einerson RR, Paternoster SF, Dewald GW. Primary pulmonary MALT lymphomas show frequent and heterogeneous cytogenetic abnormalities, including aneuploidy and translocations involving API2 and MALT1 and IGH and MALT1. Leukemia 2004;18:156–160.PubMedCrossRefGoogle Scholar
  88. 88.
    Okabe M, Inagaki H, Ohshima K, et al. API2-MALT1 fusion defines a distinctive clinicopathologic subtype in pulmonary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. Am J Pathol 2003;162:1113–1122.PubMedGoogle Scholar
  89. 89.
    Liu H, Ye H, Dogan A, et al. T(11;18)(q21;q21) is associated with advanced mucosa-associated lymphoid tissue lymphoma that expresses nuclear BCL10. Blood 2001;98:1182–1187.PubMedCrossRefGoogle Scholar
  90. 90.
    Streubel B, Lamprecht A, Dierlamm J, et al. T(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma. Blood 2003;101:2335–2339.PubMedCrossRefGoogle Scholar
  91. 91.
    Lucas PC, Yonezumi M, Inohara N, et al. Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway. J Biol Chem 2001;276:19012–19019.PubMedCrossRefGoogle Scholar
  92. 92.
    Malek SN, Hatfield AJ, Flinn IW. MALT lymphomas. Curr Treat Opt Oncol 2003;4:269–279.CrossRefGoogle Scholar
  93. 93.
    Nichols PW, Koss M, Levine AM, Lukes RJ. Lymphomatoid granulomatosis: a T-cell disorder? Am J Med 1982;72:467–471.PubMedCrossRefGoogle Scholar
  94. 94.
    Jaffe ES. Pathologic and clinical spectrum of post-thymic T-cell malignancies. Cancer Invest 1984;2:413–426.PubMedCrossRefGoogle Scholar
  95. 95.
    Myers JL, Kurtin PJ, Katzenstein AL, et al. Lymphomatoid granulomatosis. Evidence of immunophenotypic diversity and relationship to Epstein-Barr virus infection. Am J Surg Pathol 1995;19:1300–1312.PubMedCrossRefGoogle Scholar
  96. 96.
    Guinee D Jr, Jaffe E, Kingma D, et al. Pulmonary lymphomatoid granulomatosis. Evidence for a proliferation of Epstein-Barr virus infected B-lymphocytes with a prominent T-cell component and vasculitis. Am J Surg Pathol 1994;18:753–764.PubMedCrossRefGoogle Scholar
  97. 97.
    Jaffe ES, Chan JK, Su IJ, et al. Report of the Workshop on Nasal and Related Extranodal Angiocentric T/Natural Killer Cell Lymphomas. Definitions, differential diagnosis, and epidemiology. Am J Surg Pathol 1996;20:103–111.PubMedCrossRefGoogle Scholar
  98. 98.
    Teruya-Feldstein J, Jaffe ES, Burd PR, et al. The role of Mig, the monokine induced by interferon-gamma, and IP-10, the interferon-gamma-inducible protein-10, in tissue necrosis and vascular damage associated with Epstein-Barr virus-positive lymphoproliferative disease. Blood 1997;90:4099–4105.PubMedGoogle Scholar
  99. 99.
    Morice WG, Kurtin PJ, Myers JL. Expression of cytolytic lymphocyte-associated antigens in pulmonary lymphomatoid granulomatosis. Am J Clin Pathol 2002;118:391–398.PubMedCrossRefGoogle Scholar
  100. 100.
    Katzenstein AL, Carrington CB, Liebow AA. Lymphomatoid granulomatosis: a clinicopathologic study of 152 cases. Cancer 1979;43:360–373.PubMedCrossRefGoogle Scholar
  101. 101.
    Koss MN, Hochholzer L, Langloss JM, Wehunt WD, Lazarus AA, Nichols PW. Lymphomatoid granulomatosis: a clinicopathologic study of 42 patients. Pathology 1986;18:283–288.PubMedCrossRefGoogle Scholar
  102. 102.
    Fauci AS, Haynes BF, Costa J, Katz P, Wolff SM. Lymphomatoid granulomatosis. Prospective clinical and therapeutic experience over 10 years. N Engl J Med 1982;306:68–74.PubMedCrossRefGoogle Scholar
  103. 103.
    Sordillo PP, Epremian B, Koziner B, Lacher M, Lieberman P. Lymphomatoid granulomatosis: an analysis of clinical and immunologic characteristics. Cancer 1982;49:2070–2076.PubMedCrossRefGoogle Scholar
  104. 104.
    Ilowite NT, Fligner CL, Ochs HD, et al. Pulmonary angiitis with atypical lymphoreticular infiltrates in Wiskott-Aldrich syndrome: possible relationship of lymphomatoid granulomatosis and EBV infection. Clin Immunol Immunopathol 1986;41:479–484.PubMedCrossRefGoogle Scholar
  105. 105.
    Mazzie JP, Price AP, Khullar P, et al. Lymphomatoid granulomatosis in a pediatric patient. Clin Imaging 2004;28:209–213.PubMedCrossRefGoogle Scholar
  106. 106.
    Wilson WH, Kingma DW, Raffeld M, Wittes RE, Jaffe ES. Association of lymphomatoid granulomatosis with Epstein-Barr viral infection of B lymphocytes and response to interferon-alpha 2b. Blood 1996;87:4531–4537.PubMedGoogle Scholar
  107. 107.
    Dee PM, Arora NS, Innes DJ Jr. The pulmonary manifestations of lymphomatoid granulomatosis. Radiology 1982;143:613–618.PubMedGoogle Scholar
  108. 108.
    Hicken P, Dobie JC, Frew E. The radiology of lymphomatoid granulomatosis in the lung. Clin Radiol 1979;30:661–664.PubMedCrossRefGoogle Scholar
  109. 109.
    Lee JS, Tuder R, Lynch DA. Lymphomatoid granulomatosis: radiologic features and pathologic correlations. AJR Am J Roentgenol 2000;175:1335–1339.PubMedGoogle Scholar
  110. 110.
    Felgar RE, Steward KR, Cousar JB, Macon WR. T-cell-rich large-B-cell lymphomas contain non-activated CD8+ cytolytic T cells, show increased tumor cell apoptosis, and have lower Bcl-2 expression than diffuse large-B-cell lymphomas. Am J Pathol 1998;153:1707–1715.PubMedGoogle Scholar
  111. 111.
    Cleary ML, Nalesnik MA, Shearer WT, Sklar J. Clonal analysis of transplant-associated lymphoproliferations based on the structure of the genomic termini of the Epstein-Barr virus. Blood 1988;72:349–352.PubMedGoogle Scholar
  112. 112.
    Lust JA. Molecular genetics and lymphoproliferative disorders. J Clin Lab Anal 1996;10:359–367.PubMedCrossRefGoogle Scholar
  113. 113.
    Harris NL, Swerdlow S, Frizzera G, Knowles DM. Posttransplant lymphoproliferative disorders. In: Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. World Health Organization classification of tumours. Pathology and genetics of tumours of haemotopoietic and lymphoid tissues. Lyon: IARC Press, 2001:264–269.Google Scholar
  114. 114.
    Kaplan MA, Ferry JA, Harris NL, Jacobson JO. Clonal analysis of posttransplant lymphoproliferative disorders, using both episomal Epstein-Barr virus and immunoglobulin genes as markers. Am J Clin Pathol 1994;101:590–596.PubMedGoogle Scholar
  115. 115.
    Paranjothi S, Yusen RD, Kraus MD, Lynch JP, Patterson GA, Trulock EP. Lymphoproliferative disease after lung transplantation: comparison of presentation and outcome of early and late cases. J Heart Lung Transplant 2001;20:1054–1063.PubMedCrossRefGoogle Scholar
  116. 116.
    Armitage JM, Kormos RL, Stuart RS, et al. Posttransplant lymphoproliferative disease in thoracic organ transplant patients: ten years of cyclosporine-based immunosuppression. J Heart Lung Transplant 1991;10:877–886; discussion 886–887.PubMedGoogle Scholar
  117. 117.
    Reams BD, McAdams HP, Howell DN, Steele MP, Davis RD, Palmer SM. Posttransplant lymphoproliferative disorder: incidence, presentation, and response to treatment in lung transplant recipients. Chest 2003;124:1242–1249.PubMedCrossRefGoogle Scholar
  118. 118.
    Ramalingam P, Rybicki L, Smith MD, et al. Posttransplant lymphoproliferative disorders in lung transplant patients: the Cleveland Clinic experience. Mod Pathol 2002;15:647–656.PubMedCrossRefGoogle Scholar
  119. 119.
    Spiro IJ, Yandell DW, Li C, et al. Brief report: lymphoma of donor origin occurring in the porta hepatis of a transplanted liver. N Engl J Med 1993;329:27–29.PubMedCrossRefGoogle Scholar
  120. 120.
    Armes JE, Angus P, Southey MC, et al. Lymphoproliferative disease of donor origin arising in patients after orthotopic liver transplantation. Cancer 1994;74:2436–2441.PubMedCrossRefGoogle Scholar
  121. 121.
    Randhawa PS, Yousem SA. Epstein-Barr virus-associated lymphoproliferative disease in a heart-lung allograft. Demonstration of host origin by restriction fragment-length polymorphism analysis. Transplantation 1990;49:126–130.PubMedCrossRefGoogle Scholar
  122. 122.
    Collins J, Muller NL, Leung AN, et al. Epstein-Barr-virusassociated lymphoproliferative disease of the lung: CT and histologic findings. Radiology 1998;208:749–759.PubMedGoogle Scholar
  123. 123.
    Lee P, Minai OA, Mehta AC, DeCamp MM, Murthy S. Pulmonary nodules in lung transplant recipients: etiology and outcome. Chest 2004;125:165–172.PubMedCrossRefGoogle Scholar
  124. 124.
    Saxena A, Dyker KM, Angel S, Moshynska O, Dharampaul S, Cockroft DW. Posttransplant diffuse large B-cell lymphoma of “lymphomatoid granulomatosis” type. Virchows Arch 2002;441:622–628PubMedCrossRefGoogle Scholar
  125. 125.
    Diebold J, Raphael M, Prevot S, Audouin J. Lymphomas associated with HIV infection. Cancer Surv 1997;30:263–293.PubMedGoogle Scholar
  126. 126.
    Wolff AJ, O’Donnell AE. Pulmonary manifestations of HIV infection in the era of highly active antiretroviral therapy. Chest 2001;120:1888–1893.PubMedCrossRefGoogle Scholar
  127. 127.
    Eisner MD, Kaplan LD, Herndier B, Stulbarg MS. The pulmonary manifestations of AIDS-related non-Hodgkin’s lymphoma. Chest 1996;110:729–736.PubMedCrossRefGoogle Scholar
  128. 128.
    Ray P, Antoine M, Mary-Krause M, et al. AIDS-related primary pulmonary lymphoma. Am J Respir Crit Care Med 1998;158:1221–1229.PubMedGoogle Scholar
  129. 129.
    Sider L, Weiss AJ, Smith MD, VonRoenn JH, Glassroth J. Varied appearance of AIDS-related lymphoma in the chest. Radiology 1989;171:629–632.PubMedGoogle Scholar
  130. 130.
    Carignan S, Staples CA, Muller NL. Intrathoracic lymphoproliferative disorders in the immunocompromised patient: CT findings. Radiology 1995;197:53–58.PubMedGoogle Scholar
  131. 131.
    Bazot M, Cadranel J, Benayoun S, Tassart M, Bigot JM, Carette MF. Primary pulmonary AIDS-related lymphoma: radiographic and CT findings. Chest 1999;116:1282–1286.PubMedCrossRefGoogle Scholar
  132. 132.
    Haque AK, Myers JL, Hudnall SD, et al. Pulmonary lymphomatoid granulomatosis in acquired immunodeficiency syndrome: lesions with Epstein-Barr virus infection. Mod Pathol 1998;11:347–356.PubMedGoogle Scholar
  133. 133.
    Nador RG, Cesarman E, Chadburn A, et al. Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi’s sarcoma-associated herpes virus. Blood 1996;88:645–656.PubMedGoogle Scholar
  134. 134.
    Ansari MQ, Dawson DB, Nador R, et al. Primary body cavity-based AIDS-related lymphomas. Am J Clin Pathol 1996;105:221–229.PubMedGoogle Scholar
  135. 135.
    Matolcsy A, Nador RG, Cesarman E, Knowles DM. Immunoglobulin VH gene mutational analysis suggests that primary effusion lymphomas derive from different stages of B cell maturation. [see comment]. Am J Pathol 1998;153:1609–1614.PubMedGoogle Scholar
  136. 136.
    Horenstein MG, Nador RG, Chadburn A, et al. Epstein-Barr virus latent gene expression in primary effusion lymphomas containing Kaposi’s sarcoma-associated herpesvirus/human herpesvirus-8. Blood 1997;90:1186–1191.PubMedGoogle Scholar
  137. 137.
    Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM. Kaposi’s sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. [see comment]. N Engl J Med 1995;332:1186–1191.PubMedCrossRefGoogle Scholar
  138. 138.
    Cesarman E, Nador RG, Aozasa K, Delsol G, Said JW, Knowles DM. Kaposi’s sarcoma-associated herpesvirus in non-AIDS related lymphomas occurring in body cavities. Am J Pathol 1996;149:53–57.PubMedGoogle Scholar
  139. 139.
    Hengge UR, Ruzicka T, Tyring SK, et al. Update on Kaposi’s sarcoma and other HHV8 associated diseases. Part 2: pathogenesis, Castleman’s disease, and pleural effusion lymphoma. Lancet Infect Dis 2002;2:344–352.PubMedCrossRefGoogle Scholar
  140. 140.
    Cobo F, Hernandez S, Hernandez L, et al. Expression of potentially oncogenic HHV-8 genes in an EBV-negative primary effusion lymphoma occurring in an HIV-seronegative patient. J Pathol 1999;189:288–293.PubMedCrossRefGoogle Scholar
  141. 141.
    Kurosu K, Yumoto N, Rom WN, et al. Oligoclonal T cell expansions in pulmonary lymphoproliferative disorders: demonstration of the frequent occurrence of oligoclonal T cells in human immunodeficiency virus-related lymphoid interstitial pneumonia. Am J Respir Crit Care Med 2002;165:254–259.PubMedGoogle Scholar
  142. 142.
    Heitzman ER. Pulmonary neoplastic and lymphoproliferative disease in AIDS: a review. Radiology 1990;177:347–351.PubMedGoogle Scholar
  143. 143.
    Teruya-Feldstein J, Temeck BK, Sloas MM, et al. Pulmonary malignant lymphoma of mucosa-associated lymphoid tissue (MALT) arising in a pediatric HIV-positive patient. Am J Surg Pathol 1995;19:357–363.PubMedCrossRefGoogle Scholar
  144. 144.
    Mhawech P, Krishnan B, Shahab I. Primary pulmonary mucosa-associated lymphoid tissue lymphoma with associated fungal ball in a patient with human immunodeficiency virus infection. Arch Pathol Lab Med 2000;124:1506–1509.PubMedGoogle Scholar
  145. 145.
    Buckley RH. Primary immunodeficiency diseases: dissectors of the immune system. Immunol Rev 2002;185:206–219.PubMedCrossRefGoogle Scholar
  146. 146.
    Buckley RH. Pulmonary complications of primary immunodeficiencies. Paediatr Respir Rev 2004;5(suppl A):S225–S233.PubMedCrossRefGoogle Scholar
  147. 147.
    Yin EZ, Frush DP, Donnelly LF, Buckley RH. Primary immunodeficiency disorders in pediatric patients: clinical features and imaging findings. AJR Am J Roentgenol 2001;176:1541–1552.PubMedGoogle Scholar
  148. 148.
    Shackleford MD, McAlister WH. Primary immunodeficiency diseases and malignancy. AJR Radium Ther Nucl Med 1975;123:144–153.Google Scholar
  149. 149.
    Canioni D, Jabado N, MacIntyre E, Patey N, Emile JF, Brousse N. Lymphoproliferative disorders in children with primary immunodeficiencies: immunological status may be more predictive of the outcome than other criteria. Histopathology 2001;38:146–159.PubMedCrossRefGoogle Scholar
  150. 150.
    Derry JM, Ochs HD, Francke U. Isolation of a novel gene mutated in Wiskott-Aldrich syndrome. Cell 1994;78:635–644.PubMedCrossRefGoogle Scholar
  151. 151.
    Laszewski MJ, Kemp JD, Goeken JA, Mitros FA, Platz CE, Dick FR. Clonal immunoglobulin gene rearrangement in nodular lymphoid hyperplasia of the gastrointestinal tract associated with common variable immunodeficiency. Am J Clin Pathol 1990;94:338–343.PubMedGoogle Scholar
  152. 152.
    Diehl V, Stein H, Hummel M, Zollinger R, Connors JM. Hodgkin’s lymphoma: biology and treatment strategies for primary, refractory, and relapsed disease. Hematology (Am Soc Hematol Educ Program) 2003:225–247.Google Scholar
  153. 153.
    Diehl LF, Hopper KD, Giguere J, Granger E, Lesar M. The pattern of intrathoracic Hodgkin’s disease assessed by computed tomography. J Clin Oncol 1991;9:438–443.PubMedGoogle Scholar
  154. 154.
    Boshnakova T, Michailova V, Koss, Georgiev C, Todorov T, Sarbinova M. Primary pulmonary Hodgkin’s disease-report of two cases. Respir Med 2000;94:830–831.PubMedCrossRefGoogle Scholar
  155. 155.
    Kern WH, Crepeau AG, Jones JC. Primary Hodgkin’s disease of the lung. Report of 4 cases and review of the literature. Cancer 1961;14:1151–1165.PubMedCrossRefGoogle Scholar
  156. 156.
    Yousem SA, Weiss LM, Colby TV. Primary pulmonary Hodgkin’s disease. A clinicopathologic study of 15 cases. Cancer 1986;57:1217–1224.PubMedCrossRefGoogle Scholar
  157. 157.
    Radin AI. Primary pulmonary Hodgkin’s disease. Cancer 1990;65:550–563.PubMedCrossRefGoogle Scholar
  158. 158.
    Diederich S, Link TM, Zuhlsdorf H, Steinmeyer E, Wormanns D, Heindel W. Pulmonary manifestations of Hodgkin’s disease: radiographic and CT findings. Eur Radiol 2001;11:2295–2305.PubMedCrossRefGoogle Scholar
  159. 159.
    Lewis ER, Caskey CI, Fishman EK. Lymphoma of the lung: CT findings in 31 patients. AJR Am J Roentgenol 1991;156:711–714.PubMedGoogle Scholar
  160. 160.
    Harper PG, Fisher C, McLennan K, Souhami RL. Presentation of Hodgkin’s disease as an endobronchial lesion. Cancer 1984;53:147–150.PubMedCrossRefGoogle Scholar
  161. 161.
    Daly PA, O’Briain DS, Robinson I, Guckian M, Prichard JS. Hodgkin’s disease with a granulomatous pulmonary presentation mimicking sarcoidosis. Thorax 1988;43:407–409.PubMedCrossRefGoogle Scholar
  162. 162.
    Stein H, Foss HD, Durkop H, et al. CD30(+) anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features. Blood 2000;96:3681–3695.PubMedGoogle Scholar
  163. 163.
    Morris SW, Xue L, Ma Z, Kinney MC. Alk+ CD30+ lymphomas: a distinct molecular genetic subtype of non-Hodgkin’s lymphoma. Br J Haematol 2001;113:275–295.PubMedCrossRefGoogle Scholar
  164. 164.
    Haralambieva E, Pulford KA, Lamant L, et al. Anaplastic large-cell lymphomas of B-cell phenotype are anaplastic lymphoma kinase (ALK) negative and belong to the spectrum of diffuse large B-cell lymphomas. Br J Haematol 2000;109:584–591.PubMedCrossRefGoogle Scholar
  165. 165.
    Gascoyne RD, Lamant L, Martin-Subero JI, et al. ALK-positive diffuse large B-cell lymphoma is associated with Clathrin-ALK rearrangements: report of 6 cases. Blood 2003;102:2568–2573.PubMedCrossRefGoogle Scholar
  166. 166.
    Onciu M, Behm FG, Downing JR, et al. ALK-positive plasmablastic B-cell lymphoma with expression of the NPM-ALK fusion transcript: report of 2 cases. Blood 2003;102:2642–2644.PubMedCrossRefGoogle Scholar
  167. 167.
    Chott A, Kaserer K, Augustin I, et al. Ki-1-positive large cell lymphoma. A clinicopathologic study of 41 cases. Am J Surg Pathol 1990;14:439–448.PubMedCrossRefGoogle Scholar
  168. 168.
    Rush WL, Andriko JA, Taubenberger JK, et al. Primary anaplastic large cell lymphoma of the lung: a clinicopathologic study of five patients. Mod Pathol 2000;13:1285–1292.PubMedCrossRefGoogle Scholar
  169. 169.
    Arzoo KK, Bu X, Espina BM, Seneviratne L, Nathwani B, Levine AM. T-cell lymphoma in HIV-infected patients. J Acquir Immune Defic Syndr 2004;36:1020–1027.PubMedCrossRefGoogle Scholar
  170. 170.
    Nosari A, Cantoni S, Oreste P, et al. Anaplastic large cell (CD30/Ki-1+) lymphoma in HIV+ patients: clinical and pathological findings in a group of ten patients. Br J Haematol 1996;95:508–512.PubMedCrossRefGoogle Scholar
  171. 171.
    Katano H, Suda T, Morishita Y, et al. Human herpesvirus 8-associated solid lymphomas that occur in AIDS patients take anaplastic large cell morphology. Mod Pathol 2000;13:77–85.PubMedCrossRefGoogle Scholar
  172. 172.
    Lewin KJ, Ranchod M, Dorfman RF. Lymphomas of the gastrointestinal tract: a study of 117 cases presenting with gastrointestinal disease. Cancer 1978;42:693–707.PubMedCrossRefGoogle Scholar
  173. 173.
    Colby TV, Dorfman RF. Malignant lymphomas involving the salivary glands. Pathol Annu 1979;14 (pt 2):307–324.PubMedGoogle Scholar
  174. 174.
    Demirer T, Dail DH, Aboulafia DM. Four varied cases of intravascular lymphomatosis and a literature review. Cancer 1994;73:1738–1745.PubMedCrossRefGoogle Scholar
  175. 175.
    DiGiuseppe JA, Nelson WG, Seifter EJ, Boitnott JK, Mann RB. Intravascular lymphomatosis: a clinicopathologic study of 10 cases and assessment of response to chemotherapy. J Clin Oncol 1994;12:2573–2579.PubMedGoogle Scholar
  176. 176.
    Stroup RM, Sheibani K, Moncada A, Purdy LJ, Battifora H. Angiotropic (intravascular) large cell lymphoma. A clinicopathologic study of seven cases with unique clinical presentations. Cancer 1990;66:1781–1788.PubMedCrossRefGoogle Scholar
  177. 177.
    Wick MR, Mills SE. Intravascular lymphomatosis: clinicopathologic features and differential diagnosis. Semin Diagn Pathol 1991;8:91–101.PubMedGoogle Scholar
  178. 178.
    Ponzoni M, Arrigoni G, Gould VE, et al. Lack of CD 29 (beta1 integrin) and CD 54 (ICAM-1) adhesion molecules in intravascular lymphomatosis. Hum Pathol 2000;31:220–226.PubMedCrossRefGoogle Scholar
  179. 179.
    Yousem SA, Colby TV. Intravascular lymphomatosis presenting in the lung. Cancer 1990;65:349–353.PubMedCrossRefGoogle Scholar
  180. 180.
    Tan TB, Spaander PJ, Blaisse M, Gerritzen FM. Angiotropic large cell lymphoma presenting as interstitial lung disease. Thorax 1988;43:578–579.PubMedCrossRefGoogle Scholar
  181. 181.
    Morice WG, Rodriguez FJ, Hoyer JD, Kurtin PJ. Diffuse large B-cell lymphoma with distinctive patterns of splenic and bone marrow involvement: clinicopathologic features of two cases. Mod Pathol 2005;18:495–502.PubMedCrossRefGoogle Scholar
  182. 182.
    Koss MN. Pulmonary lymphoid disorders. Semin Diagn Pathol 1995;12:158–171.PubMedGoogle Scholar
  183. 183.
    Cadranel J, Wislez M, Antoine M. Primary pulmonary lymphoma. Eur Respir J 2002;20:750–762.PubMedCrossRefGoogle Scholar
  184. 184.
    Densmore JJ, Williams ME. Mantle cell lymphoma. Curr Treat Opt Oncol 2000;1:281–285.CrossRefGoogle Scholar
  185. 185.
    Muller-Hermelink HK, Montserrat E, Catovsky D, Harris NL. Chronic lymphocytic leukemia/small lymphocytic lymphoma. In: Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. World Health Organization classification of tumours. Pathology and genetics of tumours of haemotopoietic and lymphoid tissues. Lyon: IARC Press, 2001:127–130.Google Scholar
  186. 186.
    Campo E, Raffeld M, Jaffe ES. Mantle-cell lymphoma. Semin Hematol 1999;36:115–127.PubMedGoogle Scholar
  187. 187.
    Shibata K, Shimamoto Y, Nakano S, Miyahara M, Nakano H, Yamaguchi M. Mantle cell lymphoma with the features of mucosa-associated lymphoid tissue (MALT) lymphoma in an HTLV-I-seropositive patient. Ann Hematol 1995;70:47–51.PubMedCrossRefGoogle Scholar
  188. 188.
    Kurtin PJ. Mantle cell lymphoma. Adv Anat Pathol 1998;5:376–398.PubMedCrossRefGoogle Scholar
  189. 189.
    Remstein ED, Kurtin PJ, Buno I, et al. Diagnostic utility of fluorescence in situ hybridization in mantle-cell lymphoma. Br J Haematol 2000;110:856–862.PubMedCrossRefGoogle Scholar
  190. 190.
    Belaud-Rotureau MA, Parrens M, Dubus P, Garroste JC, de Mascarel A, Merlio JP. A comparative analysis of FISH, RT-PCR, PCR, and immunohistochemistry for the diagnosis of mantle cell lymphomas. Mod Pathol 2002;15:517–525.PubMedCrossRefGoogle Scholar
  191. 191.
    Isaacson PG. Lymphomas of mucosa-associated lymphoid tissue (MALT). Histopathology 1990;16:617–619.PubMedCrossRefGoogle Scholar
  192. 192.
    Nathwani B, Piris MA, Harris NL, et al. Follicular lymphoma. In: Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. World Health Organization classification of tumours. Pathology and genetics of tumours of haemotopoietic and lymphoid tissues. Lyon: IARC Press, 2001:162–167.Google Scholar
  193. 193.
    Aiello A, Du MQ, Diss TC, et al. Simultaneous phenotypically distinct but clonally identical mucosa-associated lymphoid tissue and follicular lymphoma in a patient with Sjogren’s syndrome. Blood 1999;94:2247–2251.PubMedGoogle Scholar
  194. 194.
    Attygalle A, Al-Jehani R, Diss TC, et al. Neoplastic T cells in angioimmunoblastic T-cell lymphoma express CD10. Blood 2002;99:627–633.PubMedCrossRefGoogle Scholar
  195. 195.
    Attygalle AD, Diss TC, Munson P, Isaacson PG, Du MQ, Dogan A. CD10 expression in extranodal dissemination of angioimmunoblastic T-cell lymphoma. Am J Surg Pathol 2004;28:54–61.PubMedCrossRefGoogle Scholar
  196. 196.
    Wolfe JD, Trevor ED, Kjeldsberg CR. Pulmonary manifestations of mycosis fungoides. Cancer 1980;46:2648–2653.PubMedCrossRefGoogle Scholar
  197. 197.
    Marglin SI, Soulen RL, Blank N, Castellino RA. Mycosis fungoides. Radiographic manifestations of extracutaneous intrathoracic involvement. Radiology 1979;130:35–37.PubMedGoogle Scholar
  198. 198.
    Patel DJ, Griem ML, Vijayakumar S, Griem SF. Treatment of pulmonary mycosis fungoides with whole-lung radiation therapy. J Surg Oncol 1988;38:118–120.PubMedCrossRefGoogle Scholar
  199. 199.
    van Heerde P, Feltkamp CA, Hart AA, Somers R, van Unnik JA, Vroom TM. Malignant histiocytosis and related tumors. A clinicopathologic study of 42 cases using cytological, histochemical and ultrastructural parameters. Hematol Oncol 1984;2:13–32.PubMedGoogle Scholar
  200. 200.
    Wongchaowart B, Kennealy JA, Crissman J, Hawkins H. Respiratory failure in malignant histiocytosis. Am Rev Respir Dis 1981;124:640–642.PubMedGoogle Scholar
  201. 201.
    Aozasa K, Tsujimoto M, Inoue A. Malignant histiocytosis. Report of twenty-five cases with pulmonary, renal and/or gastro-intestinal involvement. Histopathology 1985;9:39–49.PubMedCrossRefGoogle Scholar
  202. 202.
    Delsol G, Al Saati T, Gatter KC, et al. Coexpression of epithelial membrane antigen (EMA), Ki-1, and interleukin-2 receptor by anaplastic large cell lymphomas. Diagnostic value in so-called malignant histiocytosis. Am J Pathol 1988;130:59–70.PubMedGoogle Scholar
  203. 203.
    Veyssier-Belot C, Cacoub P, Caparros-Lefebvre D, et al. Erdheim-Chester disease. Clinical and radiologic characteristics of 59 cases. Medicine (Baltimore) 1996;75:157–169.CrossRefGoogle Scholar
  204. 204.
    Shamburek RD, Brewer HB Jr, Gochuico BR. Erdheim-Chester disease: a rare multisystem histiocytic disorder associated with interstitial lung disease. Am J Med Sci 2001;321:66–75.PubMedCrossRefGoogle Scholar
  205. 205.
    Egan AJ, Boardman LA, Tazelaar HD, et al. Erdheim-Chester disease: clinical, radiologic, and histopathologic findings in five patients with interstitial lung disease. Am J Surg Pathol 1999;23:17–26.PubMedCrossRefGoogle Scholar
  206. 206.
    Rush WL, Andriko JA, Galateau-Salle F, et al. Pulmonary pathology of Erdheim-Chester disease. Mod Pathol 2000;13:747–754.PubMedCrossRefGoogle Scholar
  207. 207.
    Wittenberg KH, Swensen SJ, Myers JL. Pulmonary involvement with Erdheim-Chester disease: radiographic and CT findings. AJR Am J Roentgenol 2000;174:1327–1331.PubMedGoogle Scholar
  208. 208.
    Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy. A newly recognized benign clinicopathological entity. Arch Pathol Lab Med 1969;87:63–70.Google Scholar
  209. 209.
    Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy: a pseudolymphomatous benign disorder. Analysis of 34 cases. Cancer 1972;30:1174–1188.PubMedCrossRefGoogle Scholar
  210. 210.
    Foucar E, Rosai J, Dorfman R. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): review of the entity. Semin Diagn Pathol 1990;7:19–73.PubMedGoogle Scholar
  211. 211.
    Wright DH, Richards DB. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): report of a case with widespread nodal and extra nodal dissemination. Histopathology 1981;5:697–709.PubMedCrossRefGoogle Scholar
  212. 212.
    Carbone A, Passannante A, Gloghini A, Devaney KO, Rinaldo A, Ferlito A. Review of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) of head and neck. Ann Otol Rhinol Laryngol 1999;108:1095–1104.PubMedGoogle Scholar
  213. 213.
    Carpenter RJ 3rd, Banks PM, McDonald TJ, Sanderson DR. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): Report of a case with respiratory tract involvement. Laryngoscope 1978;88:1963–1969.PubMedCrossRefGoogle Scholar
  214. 214.
    Rossi GA, Balbi B, Risso M, Repetto M, Ravazzoni C. Acute myelomonocytic leukemia. Demonstration of pulmonary involvement by bronchoalveolar lavage. Chest 1985;87:259–260.PubMedCrossRefGoogle Scholar
  215. 215.
    Rosenow EC 3rd, Wilson WR, Cockerill FR 3rd. Pulmonary disease in the immunocompromised host. 1. Mayo Clin Proc 1985;60:473–487.PubMedGoogle Scholar
  216. 216.
    Hildebrand FL Jr, Rosenow EC 3rd, Habermann TM, Tazelaar HD. Pulmonary complications of leukemia. Chest 1990;98:1233–1239.PubMedCrossRefGoogle Scholar
  217. 217.
    Green RA, Nichols NJ. Pulmonary involvement in leukemia. Am Rev Respir Dis 1959;80:833–844.Google Scholar
  218. 218.
    Palosaari DE, Colby TV. Bronchiolocentric chronic lymphocytic leukemia. Cancer 1986;58:1695–1698.PubMedCrossRefGoogle Scholar
  219. 219.
    McCabe RE, Brooks RG, Mark JB, Remington JS. Open lung biopsy in patients with acute leukemia. Am J Med 1985;78:609–616.PubMedCrossRefGoogle Scholar
  220. 220.
    Myers TJ, Cole SR, Klatsky AU, Hild DH. Respiratory failure due to pulmonary leukostasis following chemotherapy of acute nonlymphocytic leukemia. Cancer 1983;51:1808–1813.PubMedCrossRefGoogle Scholar
  221. 221.
    Lester TJ, Johnson JW, Cuttner J. Pulmonary leukostasis as the single worst prognostic factor in patients with acute myelocytic leukemia and hyperleukocytosis. Am J Med 1985;79:43–48.PubMedCrossRefGoogle Scholar
  222. 222.
    Woodard JP, Gulbahce E, Shreve M, et al. Pulmonary cytolytic thrombi: a newly recognized complication of stem cell transplantation. Bone Marrow Transplant 2000;25:293–300.PubMedCrossRefGoogle Scholar
  223. 223.
    Castellano-Sanchez AA, Poppiti RJ. Pulmonary cytolytic thrombi (PCT). A previously unrecognized complication of bone marrow transplantation (BMT). [comment]. Am J Surg Pathol 2001;25:829–831.PubMedCrossRefGoogle Scholar
  224. 224.
    Morales IJ, Anderson PM, Tazelaar HD, Wylam ME. Pulmonary cytolytic thrombi: unusual complication of hematopoietic stem cell transplantation. J Pediatr Hematol Oncol 2003;25:89–92.PubMedCrossRefGoogle Scholar
  225. 225.
    Gulbahce HE, Manivel JC, Jessurun J. Pulmonary cytolytic thrombi: a previously unrecognized complication of bone marrow transplantation. [see comment]. Am J Surg Pathol 2000;24:1147–1152.PubMedCrossRefGoogle Scholar
  226. 226.
    Yoshioka R, Yamaguchi K, Yoshinaga T, Takatsuki K. Pulmonary complications in patients with adult T-cell leukemia. Cancer 1985;55:2491–2494.PubMedCrossRefGoogle Scholar
  227. 227.
    Callahan M, Wall S, Askin F, Delaney D, Koller C, Orringer EP. Granulocytic sarcoma presenting as pulmonary nodules and lymphadenopathy. Cancer 1987;60:1902–1904.PubMedCrossRefGoogle Scholar
  228. 228.
    Hicklin GA, Drevyanko TF. Primary granulocytic sarcoma presenting with pleural and pulmonary involvement. Chest 1988;94:655–656.PubMedCrossRefGoogle Scholar
  229. 229.
    Klatte EC, Yardley J, Smith EB, Rohn R, Campbell JA. The pulmonary manifestations and complications of leukemia. AJR Radium Ther Nucl Med 1963;89:598–609.Google Scholar
  230. 230.
    Desjardins A, Ostiguy G, Cousineau S, Gyger M. Recurrent localised pneumonia due to bronchial infiltration in a patient with chronic lymphocytic leukaemia. Thorax 1990;45:570.PubMedCrossRefGoogle Scholar
  231. 231.
    Kovalski R, Hansen-Flaschen J, Lodato RF, Pietra GG. Localized leukemic pulmonary infiltrates. Diagnosis by bronchoscopy and resolution with therapy. Chest 1990;97:674–678.PubMedCrossRefGoogle Scholar
  232. 232.
    Beckman EN, Oehrle JS. Fibrous hematopoietic tumors arising in agnogenic myeloid metaplasia. Hum Pathol 1982;13:804–810.PubMedCrossRefGoogle Scholar
  233. 233.
    Asakura S, Colby TV. Agnogenic myeloid metaplasia with extramedullary hematopoiesis and fibrosis in the lung. Report of two cases. Chest 1994;105:1866–1868.PubMedCrossRefGoogle Scholar
  234. 234.
    Dingli D, Utz JP, Krowka MJ, Oberg AL, Tefferi A. Unexplained pulmonary hypertension in chronic myeloproliferative disorders. Chest 2001;120:801–808.PubMedCrossRefGoogle Scholar
  235. 235.
    Steensma DP, Hook CC, Stafford SL, Tefferi A. Low-dose, single-fraction, whole-lung radiotherapy for pulmonary hypertension associated with myelofibrosis with myeloid metaplasia. Br J Haematol 2002;118:813–816.PubMedCrossRefGoogle Scholar
  236. 236.
    Joseph G, Pandit M, Korfhage L. Primary pulmonary plasmacytoma. Cancer 1993;71:721–724.PubMedCrossRefGoogle Scholar
  237. 237.
    Koss MN, Hochholzer L, Moran CA, Frizzera G. Pulmonary plasmacytomas: a clinicopathologic and immunohistochemical study of five cases. Ann Diagn Pathol 1998;2:1–11.PubMedCrossRefGoogle Scholar
  238. 238.
    Horiuchi T, Hirokawa M, Oyama Y, et al. Diffuse pulmonary infiltrates as a roentgenographic manifestation of primary pulmonary plasmacytoma. Am J Med 1998;105:72–74.PubMedCrossRefGoogle Scholar
  239. 239.
    Amin R. Extramedullary plasmacytoma of the lung. Cancer 1985;56:152–156.PubMedCrossRefGoogle Scholar
  240. 240.
    Roikjaer O, Thomsen JK. Plasmacytoma of the lung. A case report describing two tumors of different immunologic type in a single patient. Cancer 1986;58:2671–2674.PubMedCrossRefGoogle Scholar
  241. 241.
    Garewal H, Durie BG. Aggressive phase of multiple myeloma with pulmonary cell infiltrates. JAMA 1982;248:1875–1876.PubMedCrossRefGoogle Scholar
  242. 242.
    Case records of the Massachusetts General Hospital, Case 17-1984. N Engl J Med 1984;310:1103–1112.Google Scholar
  243. 243.
    Gabriel S. Multiple myeloma presenting as pulmonary infiltration. Dis Chest 1965;47:123–126.PubMedCrossRefGoogle Scholar
  244. 244.
    Kijner CH, Yousem SA. Systemic light chain deposition disease presenting as multiple pulmonary nodules. A case report and review of the literature. Am J Surg Pathol 1988;12:405–413.PubMedCrossRefGoogle Scholar
  245. 245.
    Kaplan HS. Hodgkin’s disease. Cambridge: Harvard, 1972.Google Scholar
  246. 246.
    Valent P, Horny HP, Escribano L, et al. Diagnostic criteria and classification of mastocytosis: a consensus proposal. Leuk Res 2001;25:603–625.PubMedCrossRefGoogle Scholar
  247. 247.
    Kelly AM, Kazerooni EA. HRCT appearance of systemic mastocytosis involving the lungs. J Thorac Imaging 2004;19:52–55.PubMedCrossRefGoogle Scholar
  248. 248.
    Schmidt M, Dercken C, Loke O, et al. Pulmonary manifestation of systemic mast cell disease. Eur Respir J 2000;15:623–625.PubMedCrossRefGoogle Scholar
  249. 249.
    Li CY. Diagnosis of mastocytosis: value of cytochemistry and immunohistochemistry. Leuk Res 2001;25:537–541.PubMedCrossRefGoogle Scholar
  250. 250.
    Chan JK, Fletcher CD, Nayler SJ, Cooper K. Follicular dendritic cell sarcoma. Clinicopathologic analysis of 17 cases suggesting a malignant potential higher than currently recognized. Cancer 1997;79:294–313.PubMedCrossRefGoogle Scholar
  251. 251.
    Shah RN, Ozden O, Yeldandi A, Peterson L, Rao S, Laskin WB. Follicular dendritic cell tumor presenting in the lung: a case report. Hum Pathol 2001;32:745–749.PubMedCrossRefGoogle Scholar
  252. 252.
    Pileri SA, Grogan TM, Harris NL, et al. Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases. Histopathology 2002;41:1–29.PubMedCrossRefGoogle Scholar
  253. 253.
    Gaertner EM, Tsokos M, Derringer GA, et al. Interdigitating dendritic cell sarcoma. A report of four cases and review of the literature. Am J Clin Pathol 2001;15:589–597.Google Scholar
  254. 254.
    Grogg KL, Lae ME, Kurtin PJ, Macon WR. Clusterin expression distinguishes follicular dendritic cell tumors from other dendritic cell neoplasms: report of a novel follicular dendritic cell marker and clinicopathologic data on 12 additional follicular dendritic cell tumors and 6 additional interdigitating dendritic cell tumors. Am J Surg Pathol 2004;28:988–998.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • William George Morice
    • 1
  • Thomas V. Colby
    • 2
  1. 1.Departments of Hematopathology and Anatomic Pathology, Mayo ClinicMayo Medical SchoolRochesterUSA
  2. 2.Mayo Clinic ScottsdaleScottsdaleUSA

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