Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Alvarez-Buylla A, Kirn, Birth JR. migration, incorporation, and death of vocal control neurons in adult songbirds. J Neurobiol 1997;33(5):585–601.
Gould E, Reeves AJ, Fallah M, et al. Hippocampal neurogenesis in adult Old World primates. Proc Natl Acad Sci U S A 1999;96(9):5263–5267.
Rideout WM 3rd, Eggan K, Jaenisch R. Nuclear cloning and epigenetic reprogramming of the genome. Science 2001;293(5532):1093–1098.
Humpherys D, Eggan K, Akutsu H, et al. Epigenetic instability in ES cells and cloned mice. Science 2001;293(5527):95–97.
Majumdar MK, Thiede MA, Mosca JD, et al. Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cells. J Cell Physiol 1998;176(1):57–66.
Pereira RF, Halford KW, O'Hara MD, et al. Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice. Proc Natl Acad Sci U S A 1995;92(11):4857–4861.
Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997;276(5309):71–74.
Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284(5411):143–147.
Ferrari G, Cusella-De Angelis G, Coletta M, et al. Muscle regeneration by bone marrow-derived myogenic progenitors. Science 1998;279(5356):1528–1530.
Makino S, Fukuda K, Miyoshi S, et al. Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest 1999;103(5):697–705.
Petersen BE, Bowen WC, Patrene KD, et al. Bone marrow as a potential source of hepatic oval cells. Science 1999;284(5417):1168–1170.
Mackenzie TC, Flake AW. Human mesenchymal stem cells persist, demonstrate site-specific multipotential differentiation, and are present in sites of wound healing and tissue regeneration after transplantation into fetal sheep. Blood Cells Mol Dis 2001;27(3):601–604.
Imasawa T, Utsunamiya Y, Kawamura T, et al. The potential of bone marrow-derived cells to differentiate to glomerular mesangial cells. J Am Soc Nephrol 2001;12(7):1401–1409.
Liechty KW, MacKenzie TC, Shaaban AF, et al. Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nat Med 2000;6(11):1282–1286.
Prockop DJ, Azizi SA, Phinney DG, et al. Potential use of marrow stromal cells as therapeutic vectors for diseases of the central nervous system. Prog Brain Res 2000;128:293–297.
Bianco P, Riminucci M, Gronthos S, Robey PG. Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells 2001;19(3):180–192.
Schwarz EJ, Alexander GM, Prockop DJ, Azizi SA. Multipotential marrow stromal cells transduced to produce L-dopa: engraftment in a rat model of Parkinson disease. Hum Gene Ther 1999;10(15):2539–2549.
Chopp M, Zhang XH, Li Y, et al. Spinal cord injury in rat: treatment with bone marrow stromal cell transplantation. Neuroreport 2000;11(13):3001–3005.
Chen J, Li Y, Chopp M. Intracerebral transplantation of bone marrow with BDNF after MCAo in rat. Neuropharmacology 2000;39(5):711–716.
Li Y, Chopp M, Chen J, et al. Intrastriatal transplantation of bone marrow nonhematopoietic cells improves functional recovery after stroke in adult mice. J Cereb Blood Flow Metab 2000;20(9):1311–1319.
Kopen GC, Prockop DJ, Phinney DG. Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci U S A 1999;96(19):10711–10716.
Jiang Y, Jahagirdar BN, Reinhardt RL, et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002;418(6893):41–49.
Terada N, Hamazaki T, Oka M, et al. Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature 2002;416(6880):542–545.
Ying QL, Nichols J, Evans EP, Smith AG. Changing potency by spontaneous fusion. Nature 2002;416(6880):545–548.
Wang SH, Tsai MS, Chang MF, Li H. A novel NK-type homeobox gene, ENK (early embryo specific NK), preferentially expressed in embryonic stem cells. Gene Exp Patterns 2003;3(1):99–103.
Chambers I, Colby D, Robertson M, et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 2003;113(5):643–655.
Mitsui K, Tokuzawa Y, Itoh H, et al. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 2003;113(5):631–642.
Booth HA, Holland PW. Eleven daughters of NANOG. Genomics 2004;84(2):229–238.
Hart AH, Hartley L, Ibrahim M, Robb L. Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human. Dev Dyn 2004;230(1):187–198.
Pan GJ, Pei DQ. Identification of two distinct transactivation domains in the pluripotency sustaining factor nanog. Cell Res 2003;13(6):499–502.
Richards M, Tan SP, Tan JH, et al. The transcriptome profile of human embryonic stem cells as defined by SAGE. Stem Cells 2004;22(1):51–64.
Sato N, Meijer L, Skaltsounis L, et al. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med 2004;10(1):55–63.
Ying QL, Nichols J, Chambers I, Smith A. BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 2003;115(3):281–292.
LeBlanc A, Liu H, Goodyer C, et al. Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease. J Biol Chem 1999;274(33):23426–23436.
Piccini A, Ciotti MT, Vitolo OV, et al. Endogenous APP derivatives oppositely modulate apoptosis through an autocrine loop. Neuroreport 2000;11(7):1375–1379.
Hugon J, Esclaire F, Lesort M, et al. Toxic neuronal apoptosis and modifications of tau and APP gene and protein expressions. Drug Metab Rev 1999;31(3):635–647.
Hung AY, Koo EH, Haass C, et al. Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage. Proc Natl Acad Sci U S A 1992;89(20):9439–9443.
Murakami N, Yamaki T, Iwamoto Y, et al. Experimental brain injury induces expression of amyloid precursor protein, which may be related to neuronal loss in the hippocampus. J Neurotrauma 1998;15(11):993–1003.
Ishiguro M, Ohsawa I, Takamura C, et al. Secreted form of beta-amyloid precursor protein activates protein kinase C and phospholipase Cgamma1 in cultured embryonic rat neocortical cells. Brain Res Mol Brain Res 1998;53(1-2):24–32.
Ohsawa I, Takamura C, Kohsaka S. Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function. J Neurochem 2001;76(5):1411–1420.
Greenberg SM, Koo EH, Selkoe DJ, et al. Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation. Proc Natl Acad Sci U S A 1994;91(15):7104–7108.
Miyachi T, Asai K, Tsuiki H, et al. Interleukin-1beta induces the expression of lipocortin 1 mRNA in cultured rat cortical astrocytes. Neurosci Res 2001;40(1):53–60.
Brannen CL, Sugaya K. In vitro differentiation of multipotent human neural progenitors in serum-free medium. Neuroreport 2000;11(5):1123–1128.
Bahn S, Mimmack M, Ryan M, et al. Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study. Lancet 2002;359(9303):310–315.
Sawa A. Neuronal cell death in Down's syndrome. J Neural Transm Suppl 1999;57:87–97.
Arai Y, Suzuki A, Mizuguchi M, et al. Developmental and aging changes in the expression of amyloid precursor protein in Down syndrome brains. Brain Dev 1997;19(4):290–294.
Bondolfi L, Calhoun M, Ermini F, et al. Amyloid-associated neuron loss and gliogenesis in the neocortex of amyloid precursor protein transgenic mice. J Neurosci 2002;22(2):515–522.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer Science+Business Media, LLC
About this paper
Cite this paper
Sugaya, K., Kwak, YD., Alvarez, A. (2008). Stem Cell Therapy in Alzheimer’s Disease. In: Fisher, A., Memo, M., Stocchi, F., Hanin, I. (eds) Advances in Alzheimer’s and Parkinson’s Disease. Advances in Behavioral Biology, vol 57. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-72076-0_25
Download citation
DOI: https://doi.org/10.1007/978-0-387-72076-0_25
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-72074-6
Online ISBN: 978-0-387-72076-0
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)