Due to recent advances in new and successful treatments the consequences of receiving a diagnosis of cancer in childhood have dramatically changed. Children and adolescents with cancer, who may have had a limited life expectancy a few decades ago, are now often surviving into adulthood. The overall five-year survival was over 72% for all pediatric malignancies in 19 European countries in the period 1978−1997 [1]. In the UK, the overall survival was 75% between 1992 and 1996 [2] with the highest survival for survivors of Hodgkin’s disease (95%) and retinoblastoma (95%) and the lowest for primitive neuroectodermal tumors (50%) and neuroblastoma (55%). The overall survival in the US was 80% in the period 1996−2003 compared to 62% in 1975–1977 [3]. The highest survival rates in the US were found for survivors of Hodgkin’s disease (95%) and Wilm’s tumor (92%), while the lowest survival rate of 50% was found for survivors of acute myeloid leukemia [3].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Pritchard-Jones K, Kaatsch P, Steliarova-Foucher E, Stiller CA, Coebergh JW. Cancer in children and adolescents in Europe: developments over 20 years and future challenges. Eur J Cancer. 2006; 42(13):2183–90.
UK stat: http://info.cancerresearchuk.org/cancerstats/childhoodcancer/survival/?a=5441 Accessed at 4th March 2008.
Ries LAG, Melbert D, Krapcho M, Mariotto A, Miller BA, Feuer EJ, et al. (eds.) SEER Cancer Statistics Review, 1975–2004, National Cancer Institute. Bethesda, MD: http://seer.cancer.gov/csr/1975_2004/, based on November 2006 SEER data submission, posted to the SEER web site, 2007. Accessed at 4th March 2008.
Robison LL, Hudson MM. Medical surveillance of long-term survivors of childhood cancer. Eur J Cancer. 2007; 43:2629–30.
Oeffinger KC, Mertens AC, Sklar CA, Kawashima T, Hudson MM, Meadows AT, et al. Childhood Cancer Survivor Study. Chronic health conditions in adult survivors of childhood cancer. N Engl J Med. 2006; 355:1572–82.
Geenen MM, Cardous-Ubbink MC, Kremer LC, van den Bos C, van der Pal HJ, Heinen RC, et al. Medical assessment of adverse health outcomes in long-term survivors of childhood cancer. JAMA. 2007; 297:2705–15.
Eiser C, Hill JJ, Vance YH. Examining the psychological consequences of surviving childhood cancer: systematic review as a research method in pediatric psychology. J Pediatr Psychol. 2000; 25:449–60.
Langeveld NE, Stam H, Grootenhuis MA, Last BF. Quality of life in young adult survivors of childhood cancer. Support Care Cancer. 2002; 10:579–600.
Stam H, Grootenhuis MA, Last BF. The course of life of survivors of childhood cancer. Psycho-oncology. 2005; 14:227–238.
Ness KK, Mertens AC, Hudson MM, et al. Limitations on physical performance and daily activities among long-term survivors of childhood cancer. Ann Inter Med. 2005; 143:639–47.
Macedoni-Luksic M, Jereb B, Todorovski L. Long-term sequelae in children treated for brain tumors: impairment, disability and handicap. Ped Hematol Oncol. 2003; 20:89–101.
Hays DM. Adult survivors of childhood cancer. Employment and insurance issues in different age groups. Cancer. 1993; 71(10 Suppl):3306–9.
Henrichs MH. Principles of psychosocial oncology. In: Rubin P (ed). Clinical Oncology. Philadelphia: WB Saunders, 1993.
Badell I, Igual L, Gomez P, Bureo E, Ortega JJ, Cubells J, et al. Quality of life in young adults having received a BMT during childhood: a GETMON study. Bone Marrow Transplant. 1998; 21 (Suppl 2):S68–71.
Seitzman RL, Glover DA, Meadows AT, Mills JL, Nicholson HS, Robison LL, et al. Self-concept in adult survivors of childhood acute lymphoblastic leukemia: a cooperative Children’s Cancer Group and National Institutes of Health study. Pediatr Blood Cancer. 2004; 42:230–240.
Verbeek J, Spelten E. Work. In: Feuerstein, M. (ed). Handbook of cancer survivorship. Berkely: Springer, 2007.
Tebbi CK, Bromberg C, Piedmonte M. Long-term vocational adjustment of cancer patients diagnosed during adolescence. Cancer. 1989; 63:213–8.
Feldman, FR. Work and cancer health histories: work expectations and experiences of youth with cancer histories (ages 13–23). Oakland, CA: California Division, American Cancer Society, 1980.
Koocher GP. Surviving childhood cancer: issues in living. In: Spinetta JJ, Deasy-Spinetta P, (eds). Living with childhood cancer. St. Louis: CBV Mosby, 1981; 171–83.
de Boer AG, Verbeek JH, van Dijk FJ. Adult survivors of childhood cancer and unemployment: A meta-analysis. Cancer. 2006; 107:1–11.
Evans SE, Radford M. Current lifestyle of young adults treated for cancer in childhood. Arch Dis Child. 1995; 72:423–6.
Green DM, Zevon MA, Hall B. Achievement of life goals by adult survivors of modern treatment for childhood cancer. Cancer. 1991; 67:206–13.
Hays DM, Landsverk J, Sallan SE, Hewett KD, Patenaude AF, Schoonover D, et al. Educational, occupational, and insurance status of childhood cancer survivors in their fourth and fifth decades of life. J Clin Oncol. 1992; 10:1397–1406.
Zevon MA, Neubauer NA, Green DM. Adjustment and vocational satisfaction of patients treated during childhood or adolescence for acute lymphoblastic leukemia. Am J Pediatr Hematol Oncol. 1990; 12:454–61.
Wasserman AL, Thompson EI, Wilimas JA, Fairclough DL. The psychological status of survivors of childhood/adolescent Hodgkin’s disease. Am J Dis Child. 1987; 141:626–31.
Teta MJ, Del Po MC, Kasl SV, Meigs JW, Myers MH, Mulvihill JJ. Psychosocial consequences of childhood and adolescent cancer survival. J Chronic Dis. 1986; 39:751–9.
Feuerstein M, Luff GM, Harrington CB, Olsen CH. Pattern of workplace disputes in cancer survivors: a population study of ADA claims. J Cancer Surv. 2007; 1:185–192.
Boman KK, Bodegard G. Life after cancer in childhood: social adjustment and educational and vocational status of young-adult survivors. J Pediatr Hematol Oncol. 2004; 26:354–362.
Dolgin MJ, Somer E, Buchvald E, Zaizov R. Quality of life in adult survivors of childhood cancer. Soc Work Health Care. 1999; 28:31–43.
Mackie E, Hill J, Kondryn H, McNally R. Adult psychosocial outcomes in long-term survivors of acute lymphoblastic leukaemia and Wilms’tumor: a controlled study. Lancet. 2000; 355:1310–4.
Moe PJ, Holen A, Glomstein A, Madsen B, Hellebostad M, Stokland T, et al. Long-term survival and quality of life in patients treated with a national all protocol 15–20 years earlier: IDM/HDM and late effects? Pediatr Hematol Oncol. 1997; 14:513–24.
Pastore G, Mosso ML, Magnani C, Luzzatto L, Bianchi M, Terracini B. Physical impairment and social life goals among adult long-term survivors of childhood cancer: a population-based study from the childhood cancer registry of Piedmont, Italy. Tumori. 2001; 87:372–8.
Pui CH, Cheng C, Leung W, Rai SN, Rivera GK, Sandlund JT, et al. Extended follow-up of long-term survivors of childhood acute lymphoblastic leukemia. N Engl J Med. 2003; 349:640–9.
Zeltzer LK, Chen E, Weiss R, Guo MD, Robison LL, Meadows AT, et al. Comparison of psychologic outcome in adult survivors of childhood acute lymphoblastic leukemia versus sibling controls: a cooperative Children's Cancer Group and National Institutes of Health study. J Clin Oncol. 1997; 15:547–56.
Felder-Puig R, Peters C, Matthes-Martin S, Lamche M, Felsberger C, Gadner H, et al. Psychosocial adjustment of pediatric patients after allogeneic stem cell transplantation. Bone Marrow Transplant. 1999; 24:75–80.
Haddy TB, Adde MA, Magrath IT. Health lifestyles, risk-taking behavior and attitudes of long-term survivors of non-Hodgkin’s lymphoma. Int J Ped Hematol/Oncol. 2001; 7:57–70.
Fischer EG, Welch K, Shillito J, Winston KR, Tarbell NJ. Craniopharyngiomas in children. J Neurosurg. 1990; 73:534–40.
Jenkin D, Danjoux C, Greenberg M. Subsequent quality of life for children irradiated for a brain tumor before age four years. Med Pediatr Oncol. 1998; 31:506–11.
Kiltie AE, Lashford LS, Gattamaneni HR. Survival and late effects in medulloblastoma patients treated with craniospinal irradiation under three years old. Med Pediatr Oncol. 1997; 28:348–54.
Lannering B, Marky I, Lundberg A, Olsson E. Long-term sequelae after pediatric brain tumors: their effect on disability and quality of life. Med Pediatr Oncol. 1990; 18: 304–10.
Maddrey AM, Bergeron JA, Lombardo ER, McDonald NK, Mulne AF, Barenberg PD, et al.. Neuropsychological performance and quality of life of 10 year survivors of childhood medulloblastoma. J Neuro-Oncol. 2005; 72:245–53.
Mostow EN, Byrne J, Connelly RR, Mulvihill JJ. Quality of life in long-term survivors of CNS tumors of childhood and adolescence. J Clin Oncol. 1991; 9:592–9.
Sutton LN, Radcliffe J, Goldwein JW, Phillips P, Janss AJ, Packer RJ, et al. Quality of life of adult survivors of germinomas treated with craniospinal irradiation. Neurosurgery. 1999; 45:1292–7.
Nagarajan R, Neglia JP, Clohisy DR, Yasui Y, Greenberg M, Hudson M, et al. Education, employment, insurance, and marital status among 694 survivors of pediatric lower extremity bone tumors: a report from the childhood cancer survivor study. Cancer. 2003; 97:2554–64.
Novakovic B, Fears TR, Horowitz ME, Tucker MA, Wexler LH. Late effects of therapy in survivors of Ewing’s sarcoma family tumors. J Ped Hematol Oncol. 1997; 19:220–5.
Nicholson HS, Mulvihill JJ, Byrne J. Late effects of therapy in adult survivors of osteosarcoma and Ewing’s sarcoma. Med Pediatr Oncol. 1992; 20:6–12.
Eiser C, Cool P, Grimer RJ, Carter SR, Cotter IM, Ellis AJ, et al. Quality of life in children following treatment for a malignant primary bone tumor around the knee. Sarcoma. 1997; 1:39–45.
Felder-Puig R, Formann AK, Mildner A, Bretschneider W, Bucher B, Windhager R, et al. Quality of life and psychosocial adjustment of young patients after treatment of bone cancer. Cancer. 1998; 83:69–75.
Langeveld NE, Ubbink MC, Last BF, Grootenhuis MA, Voute PA, de Haan RJ. Educational achievement, employment and living situation in long-term young adult survivors of childhood cancer in the Netherlands. Psycho-oncology. 2003; 12:213–25.
Byrne J, Fears TR, Whitney C, Parry DM. Survival after retinoblastoma: long-term consequences and family history of cancer. Med Pediatr Oncol. 1995; 24:160–5.
Meadows AT, McKee L, Kazak AE. Psychosocial status of young adult survivors of childhood cancer: a survey. Med Pediatr Oncol. 1989; 17:466–70.
Pang JW, Friedman DL, Whitton JA, Stovall M, Mertens AC, Robison LL, et al. Employment status among adult survivors in the Childhood Cancer Survivor Study. Pediatr Blood Cancer. 2008; 50:104–10.
Punyko JA, Gurney JG, Scott Baker K, Hayashi RJ, Hudson MM, Liu Y, et al. Physical impairment and social adaptation in adult survivors of childhood and adolescent rhabdomyosarcoma: a report from the Childhood Cancer Survivors Study. Psychooncology. 2007; 16:26–37.
Crom DB, Lensing SY, Rai SN, Snider MA, Cash DK, Hudson MM. Marriage, employment, and health insurance in adult survivors of childhood cancer. J Cancer Surviv. 2007; 1:237–45.
Servitzoglou M, Papadatou D, Tsiantis I, Vasilatou-Kosmidis H. Psychosocial functioning of young adolescent and adult survivors of childhood cancer. Support Care Cancer. 2008; 16:29–36.
Gerhardt CA, Dixon M, Miller K, Vannatta K, Valerius KS, Correll J, et al. Educational and occupational outcomes among survivors of childhood cancer during the transition to emerging adulthood. J Dev Behav Pediatr. 2007; 28:448–55.
Johannesen TB, Langmark F, Wesenberg F, Lote K. Prevalence of Norwegian patients diagnosed with childhood cancer, their working ability and need of health insurance benefits. Acta Oncol. 2007; 46:60–6.
Gerber LH, Hoffman K, Chaudhry U, Augustine E, Parks R, Bernad M, et al. Functional outcomes and life satisfaction in long-term survivors of pediatric sarcomas. Arch Phys Med Rehabil. 2006; 87:1611–7.
Mitby PA, Robison LL, Whitton JA, Zevon MA, Gibbs IC, Tersak JM, et al. Childhood Cancer Survivor Study Steering Committee. Utilization of special education services and educational attainment among long-term survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. Cancer. 2003; 97:1115–26.
Barrera M, Shaw AK, Speechley KN, Maunsell E, Pogany L. Educational and social late effects of childhood cancer and related clinical, personal, and familial characteristics. Cancer. 2005; 104:1751–60.
Palmer SL, Reddick WE, Gajjar A. Understanding the cognitive impact on children who are treated for medulloblastoma. J Pediatr Psychol. 2007; 32:1040–9.
Upton P, Eiser C. School experiences after treatment for a brain tumor. Child Care Health Dev. 2006; 32:9–17.
Kingma A, Rammeloo LA, van Der Does-van den Berg A, Rekers-Mombarg L, Postma A. Academic career after treatment for acute lymphoblastic leukaemia. Arch Dis Child. 2000; 82:353–7.
Harila-Saari AH, Lähteenmäki PM, Pukkala E, Kyyrönen P, Lanning M, Sankila R. Scholastic achievements of childhood leukemia patients: a nationwide, register-based study. J Clin Oncol. 2007; 25:3518–24.
Elad P, Yagil Y, Cohen L, Meller I. A jeep trip with young adult cancer survivors: lessons to be learned. Support Care Cancer. 2003; 11:201–6.
Zebrack BJ, Oeffinger KC, Hou P, Kaplan S. Advocacy skills training for young adult cancer survivors: the Young Adult Survivors Conference at Camp Māk-a-Dream. Support Care Cancer. 2006; 14:779–82.
Blacklay A, Eiser C, Ellis A. Development and evaluation of an information booklet for adult survivors of cancer in childhood. The United Kingdom Children’s Cancer Study Group Late Effects Group. Arch Dis Child. 1998; 78:340–4.
St. Louis Late Effects Program. http://www.stlouischildrens.org/tabid/211/itemid/4221/Late-Effects-Program.aspx. Accessed at April 1st 2008.
Texas Children’s Center. http://www.cancersurvivorchild.org/frame_dyn.html?future/index.html. Accessed at April 1, 2008.
Chan, F, Strauser, D, Cardoso, EdS, Zheng, LX, Chan, JYC, Feuerstein, M. State vocational services and employment in cancer survivors. J Cancer Surviv. 2008; 2:169–78.
WHO. International Classification of Functioning, Disability and Health. Geneva: WHO; 2001.
Cole PD, Kamen BA. Delayed neurotoxicity associated with therapy for children with acute lymphoblastic leukemia. Ment Retard Dev Disabil Res Rev. 2006; 12:174–83.
Bouknight RR, Bradley CJ, Luo Z. Correlates of return to work for breast cancer survivors. J Clin Oncol. 2006; 24:345–53.
Skinner R, Wallace WH, Levitt G. Long-term follow-up of children treated for cancer: why is it necessary, by whom, where and how? Arch Dis Child. 2007; 92:257–60.
Verbeek J, Spelten E, Kammeijer M, Sprangers M. Return to work of cancer survivors: a prospective cohort study into the quality of rehabilitation by occupational physicians. Occup Environ Med. 2003; 60:352–7.
de Boer AG, Verbeek JH, Spelten ER, Uitterhoeve AL, Ansink AC, de Reijke TM, et al. Work ability and return-to-work in cancer patients. Br J Cancer. 2008; 98:1342–7.
Leventhal H, Nerenz DR, Steele, DJ. Illness representations and coping with health threats. In: Baum A, Taylor SE, Singer JE (eds). Handbook of psychology and health, Erlbaum: London, 1984.
Petrie KJ, Cameron LD, Ellis CJ, Buick D, Weinman J. Changing illness perceptions after myocardial infarction: an early intervention randomized controlled trial. Psychosom Med. 2002; 64:580–6.
McGrath KA, Truesdell SC. Employability and career counseling for adolescents and adults with congenital heart disease. Nurs Clin North Am. 1994; 29:319–30.
White PH, Shear ES. Transition/job readiness for adolescents with juvenile arthritis and other chronic illness. J Rheumatol Suppl. 1992; 33:23–7.
Spelten ER, Sprangers MA, Verbeek JH. Factors reported to influence the return to work of cancer survivors: a literature review. Psychooncology. 2002; 11:124–31.
Taskila T, Lindbohm ML. Factors affecting cancer survivors' employment and work ability. Acta Oncol. 2007; 46:446–51.
Main D, Nowels C, Cavender T, Etschmaier M, Steiner J. A qualitative study of work and work return in cancer survivors. Psycho-Oncology 2005; 14:992–1004.
Nachreiner N, Dagher CR, McGovern P, Baker B, Alexander B, Gerberich S. Succesfull return to work for cancer survivors. Business and Leadership 2007; 55:290–5.
Maunsell E, Brisson C, Dubois L, Lauzier S, Frazer A. Work problems after breast cancer : an exploratory qualitative study. Psycho-Oncology 1999; 8:467–3.
Kennedy F, Haslam C, Munir F, Pryce J. Returning to work following cancer: a qualitative exploratory study into the experience of returning to work following cancer. Eur J Cancer Care 2007; 16:17–25.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2009 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
de Boer, A., Verbeek, J., van Dijk, F. (2009). Young Survivors of Childhood Cancer. In: Work and Cancer Survivors. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72041-8_8
Download citation
DOI: https://doi.org/10.1007/978-0-387-72041-8_8
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-72040-1
Online ISBN: 978-0-387-72041-8
eBook Packages: MedicineMedicine (R0)