(Super)paramagnetic Nanoparticles: Applications in Noninvasive MR Imaging of Stem Cell Transfer

  • Glenn A. Walter
  • Swadeshmukul Santra
  • Bijoy Thattaliyath
  • Samuel C. Grant
Part of the Fundamental Biomedical Technologies book series (FBMT, volume 102)


Common techniques to monitor muscle stem cell transplants typically rely on ex vivo genetic modification to allow expression of reporter genes. Specific reporter genes allow for graft identification during post-mortem analysis. The use of these invasive techniques makes even simple and practical questions difficult and labor intensive to answer. The design and improvement of the stem cell-based therapies will be greatly facilitated by the development of sensitive, noninvasive, and nondestructive techniques for tracking stem cells following implantation or infusion. MR offers such an opportunity, due to its ability to obtain high-resolution 3D images repeatedly and noninasively. Reliable tracking by MR imaging can be achieved by labeling cells with (super)paramagnetic nanoparticles. In this chapter, we discuss recent advances in the development and applications of (super)paramagnetic nanoparticles for in vivo cell tracking and targeting.


Stem Cell Contrast Agent Magn Reson Image Superparamagnetic Iron Oxide Chemical Exchange Saturation Transfer 


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© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Glenn A. Walter
  • Swadeshmukul Santra
  • Bijoy Thattaliyath
  • Samuel C. Grant

There are no affiliations available

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