Abstract
Among many pathological processes, angiogenesis, the formation of new blood vessels from pre-existing blood vessels, has received much attention during the last few decades in the field of oncology, since it was postulated that tumor growth is angiogenesis dependent. Therefore, therapies that are aimed to inhibit angiogenesis are promising interventions for cancer. Imaging methods to evaluate angiogenesis are becoming increasingly important and especially the area of molecular imaging highly depends on suitable and specific contrast agents.
Nanotechnology offers the unique possibility to create nanoscale devices that can have multiple properties integrated.
In this chapter the synthesis and application of two types of nanoparticles with fluorescent and magnetic properties for multimodality imaging, i.e. magnetic resonance imaging (MRI) and optical techniques, will be discussed. The first part deals with a nanoparticle based on liposomes which was used to visualize and quantify tumor angiogenesis in vivo with MRI, after applying angiostatic therapy. The second part of this chapter focuses on a nanoparticle that is based on fluorescent quantum dots with a paramagnetic micellar coating. We demonstrate the applicability of this contrast agent for parallel intravital microscopy and MRI in vivo.
Both nanoparticles were shown to be very useful for molecular imaging of tumor angiogenesis.
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Aime, S., Dastru, W., Crich, S.G., Gianolio, E., Mainero, V., 2002. Innovative magnetic resonance imaging diagnostic agents based on paramagnetic Gd(III) complexes, Biopolymers 66,6, 419–428.
Bangham, A.D., Standish, M.M.,Watkins, J.C., 1965. Diffusion of univalent ions across the lamellae of swollen phospholipids J Mol Biol 13, 1, 238–252.
Dafni, H., Israely, T., Bhujwalla, Z.M., Benjamin, L.E., Neeman, M., 2002. Overexpression of vascular endothelial growth factor 165 drives peritumor interstitial convection and induces lymphatic drain: magnetic resonance imaging, confocal microscopy, and histological tracking of triple-labeled albumin, Cancer Res 62, 22, 6731–6739.
Darbandi, M., Thomann, R., Nann, T., 2005. Single quantum dots in silica spheres by microemulsion synthesis, Chemistry of Materials 17, 23, 5720–5725.
de Lussanet, Q.G., Langereis, S., Beets-Tan, R.G., van Genderen, M.H., Griffioen, A.W., van Engelshoven, J.M., and Backes, W.H., 2005. Dynamic contrast-enhanced MR imaging kinetic parameters and molecular weight of dendritic contrast agents in tumor angiogenesis in mice, Radiology 235, 1, 65–72.
Donega, C.D., Liljeroth, P., Vanmaekelbergh, D., 2005. Physicochemical evaluation of the hot-injection method, a synthesis route for monodisperse nanocrystals, Small, 1,12, 1152–1162.
Dubertret, B., Skourides, P., Norris, D.J., Noireaux, V., Brivanlou, A.H., Libchaber, A., 2002. In vivo imaging of quantum dots encapsulated in phospholipid micelles, Science, 298,5599, 1759–1762.
Folkman, J., 1971. Tumor angiogenesis: therapeutic implications, N Engl J Med 285,21, 1182–1186.
Folkman, J., 2003. Angiogenesis inhibitors: a new class of drugs, Cancer Biol Ther 2,4 Suppl 1, S127–S133.
Giancotti, F.G., Ruoslahti, E., 1999. Integrin signaling, Science 285,5430, 1028–1032.
Griffioen, A.W., Molema, G., 2000. Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation, Pharmacol Rev 52,2, 237–268.
Haubner, R., Wester, H.J., Weber, W.A., Mang, C., Ziegler, S.I., Goodman, S.L., Senekowitsch-Schmidtke, R., Kessler, H., Schwaiger, M., 2001. Noninvasive imaging of alpha(v)beta3 integrin expression using 18F-labeled RGD-containing glycopeptide and positron emission tomography, Cancer Res 61,5, 1781–1785.
Hood, J.D., Bednarski, M., Frausto, R., Guccione, S., Reisfeld, R.A., Xiang, R., Cheresh, D.A., 2002. Tumor regression by targeted gene delivery to the neovasculature, Science 296,5577, 2404–2407.
Huber, M.M., Staubli, A.B., Kustedjo, K., Gray, M.H., Shih, J., Fraser, S.E., Jacobs, R.E., Meade, T.J., 1998. Fluorescently detectable magnetic resonance imaging agents, Bioconjug Chem 9,2, 242–249.
Jain, R.K., Munn, L.L., Fukumura, D., 2002. Dissecting tumour pathophysiology using intravital microscopy, Nat Rev Cancer 2, 4, 266–276.
Kracht, L.W., Friese, M., Herholz, K., Schroeder, R., Bauer, B., Jacobs, A., Heiss, W.D., 2003. Methyl-[11C]-l-methionine uptake as measured by positron emission tomography correlates to microvessel density in patients with glioma, Eur J Nucl Med Mol Imaging 30,6, 868–873.
Lewin, M., Carlesso, N., Tung, C.H., Tang, X.W., Cory, D., Scadden, D.T., Weissleder, R., 2000. Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells, Nat Biotechnol 18,4, 410–414.
McDonald, D.M., Choyke, P.L., 2003. Imaging of angiogenesis: from microscope to clinic, Nat Med, 9, 6, 713–725.
Medintz, I.L., Uyeda, H.T., Goldman, E.R., Mattoussi, H., 2005. Quantum dot bioconjugates for imaging, labelling and sensing, Nat Mater 4,6, 435–446.
Michalet, X., Pinaud, F.F., Bentolila, L.A., Tsay, J.M., Doose, S., Li, J.J., Sundaresan, G., Wu, A.M., Gambhir, S.S., Weiss, S., 2005. Quantum dots for live cells, in vivo imaging, and diagnostics, Science 307, 5709, 538–544.
Mulder, W.J., Koole, R., Brandwijk, R.J., Storm, G., Chin, P.T., Strijkers, G.J., de Mello, D.C., Nicolay, K., Griffioen, A.W., 2006a. Quantum dots with a paramagnetic coating as a bimodal molecular imaging probe, Nano Lett, 6, 1, 1–6.
Mulder, W.J., Strijkers, G.J., Griffioen, A.W., van Bloois, L., Molema, G., Storm, G., Koning, G.A., Nicolay, K., 2004. A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets, Bioconjug Chem, 15, 4, 799–806.
Mulder, W.J., Strijkers, G.J., Habets, J.W., Bleeker, E.J., van der Schaft, D.W., Storm, G., Koning, G.A., Griffioen, A.W., Nicolay, K., 2005. MR molecular imaging and fluorescence microscopy for identification of activated tumor endothelium using a bimodal lipidic nanoparticle, FASEB J, 19,14, 2008–2010.
Mulder, W.J., Strijkers, G.J., van Tilborg, G.A., Griffioen, A.W., Nicolay, K., 2006b. Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging, NMR Biomed, 19,1, 142–164.
Roy, I., Ohulchanskyy, T.Y., Bharali, D.J., Pudavar, H.E., Mistretta, R.A., Kaur, N., Prasad, P.N., 2005. Optical tracking of organically modified silica nanoparticles as DNA carriers: a nonviral, nanomedicine approach for gene delivery, Proc Natl Acad Sci U S A., 102,2, 279–284.
Sipkins, D.A., Cheresh, D.A., Kazemi, M.R., Nevin, L.M., Bednarski, M.D., Li, K.C., 1998. Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging, Nat Med, 4,5, 623–626.
Stroh, M., Zimmer, J.P., Duda, D.G., Levchenko, T.S., Cohen, K.S., Brown, E.B., Scadden, D.T., Torchilin, V.P., Bawendi, M.G., Fukumura, D., Jain, R.K., 2005. Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo, Nat Med, 11,6, 678–682.
Torchilin, V.P., 2005. Recent advances with liposomes as pharmaceutical carriers, Nat Rev Drug Discov, 4,2, 145–160.
van Beijnum, J.R., Griffioen, A.W., 2005. In silico analysis of angiogenesis associated gene expression identifies angiogenic stage related profiles, Biochim Biophys Acta, 1755, 2, 121–134.
Weissleder, R., 2002. Scaling down imaging: molecular mapping of cancer in mice, Nat Rev Cancer, 2, 1, 11–18.
Weissleder, R., Mahmood, U., 2001. Molecular imaging, Radiology, 219,2, 316–333.
Winter, P.M., Caruthers, S.D., Kassner, A., Harris, T.D., Chinen, L.K., Allen, J.S., Lacy, E.K., Zhang, H., Robertson, J.D., Wickline, S.A., Lanza, G.M., 2003. Molecular imaging of angiogenesis in nascent Vx2 rabbit tumors using a novel alpha(nu)beta3targeted nanoparticle and 1.5 tesla magnetic resonance imaging, Cancer Res, 63,18, 5838–5843.
Xie, R., Kolb, U., Li, J., Basche, T., Mews, A., 2005. Synthesis and characterization of highly luminescent CdSe-core CdS/Zn0.5Cd0.5S/ZnS multishell nanocrystals, J Am Chem Soc, 127, 20, 7480–7488.
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Mulder, W.J. et al. (2008). Bimodal Liposomes and Paramagnetic QD-Micelles for Multimodality Molecular Imaging of Tumor Angiogenesis. In: Bulte, J.W., Modo, M.M. (eds) Nanoparticles in Biomedical Imaging. Fundamental Biomedical Technologies, vol 102. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72027-2_23
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DOI: https://doi.org/10.1007/978-0-387-72027-2_23
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