Introduction: The Emergence of Nanoparticles as Imaging Platform in Biomedicine
Nanoparticles have now emerged as widely used diagnostic agents in biomedicine. They possess unique features that can be exploited with imaging. Among these are an increased sensitivity in detection through amplification of signal changes; a manipulation of surface structures and enhancement of uptake by selected cells (macrophages); altered pharmacokinetics allowing, for instance, their use as blood pool imaging agents; and physicochemical manipulations of energy (i.e., quantum dots). Specific aspects of nanoparticles are introduced to illustrate their use in biomedical imaging.
KeywordsContrast Agent Myocardial Perfusion Imaging Colloidal Gold Biomedical Imaging Chemical Exchange Saturation Transfer
Unable to display preview. Download preview PDF.
- Ohgushi, M., Nagayama, K., Wada, A., 1978. Dextran-magnetite: new relaxation agent and its application to T2 measurements in gel. J Magn Reson 29, 599–601.Google Scholar
- Renshaw, P.F., Owen, C.S., McLaughlin, A.C., Frey, T.G., Leigh, J.S., Jr., 1986b. Ferromagnetic contrast agents: a new approach. Magn Reson Med 3, 217-225.Google Scholar
- Rifkind, D.A., Hsu, K.C., Morgan, Seegal, B.C., Knox, A.W., Rose, H.M., 1960. Use of ferritin-conjugated antibody to localize antigen by electron microscopy. Nature 187, 1094-1095.Google Scholar