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Vaccine Containing Natural TLR Ligands Protects from Salmonella typhimurium Infection in Mice and Acute Respiratory Infections in Children

  • Boris Semenov
  • Vitaly Zverev
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 601)

Abstract

It has been shown that a single parenteral administration of vaccine containing bacterial ligands for TLR1, TLR2, TLR4, TLR6, and TLR9 in mice induced rapid (24 h after administration) and effective (100%), but short-term (96 h) protection against lethal challenge with Salmonella typhimurium. Repeated mucosal applications of this vaccine stimulated long-term (up to 9 months) protection against acute respiratory infections in children of preschool age.

Keywords

Innate Immunity Avian Influenza Avian Influenza Virus Acute Respiratory Infection Lethal Challenge 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  1. 1.Mechnikov Research Institute of Vaccines and SeraMoscowRussia

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