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Interleukin-7 Immunotherapy

  • Conference paper
Immune-Mediated Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 601))

Abstract

IL-7 is a member of the common γ -chain family of cytokines sharing a common γ -chain in their receptor. Beyond its long-established pivotal role in immune development, it has been more recently recognized as a critically important regulator of peripheral naïve and memory T cell homeostasis while its role in postdevelopment thymic function remains at best, poorly defined, and controversial. Its multiple immune-enhancing properties, most notably in the maintenance of T cell homeostasis, make it a very attractive candidate for immunotherapy in a wide variety of clinical situations. Following many years of rich preclinical data in murine and simian models, IL-7 is now emerging in human phase I trials as a very promising immunotherapeutic agent. Human in vivo data discussed here are derived from the phase I study initiated at the National Cancer Institute in collaboration with Cytheris, Inc., in a cohort of subjects with incurable malignancy.

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Authors and Affiliations

  1. Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Claude Sportès & Ronald E. Gress

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  1. Claude Sportès
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  2. Ronald E. Gress
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Correspondence to Claude Sportès .

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Editors and Affiliations

  1. Division of Clinical Immunopathology, 5725 Children’s Hospital of Pittsburgh, Main Tower, 200 Lothrop Street, Pittsburgh, PA, 15213, USA

    Michael R. Shurin (Associate Professor of Pathology and Immunology, Associate Director) (Associate Professor of Pathology and Immunology, Associate Director)

  2. Institute for Continuing Medical Education, Russian Association of Pediatric Allergology and Immunology, Clinical and Research Center of Allergy and Immunology, Ostrovitianova St., Bldg. 6, Moscow, 117513, Russia

    Yuri S. Smolkin (Professor of Immunology, Vise-President, Director) (Professor of Immunology, Vise-President, Director)

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Sportès, C., Gress, R.E. (2007). Interleukin-7 Immunotherapy. In: Shurin, M.R., Smolkin, Y.S. (eds) Immune-Mediated Diseases. Advances in Experimental Medicine and Biology, vol 601. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72005-0_35

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