Rational Development of Antigen-Specific Therapies for Type 1 Diabetes

  • Georgia Fousteri
  • Damien Bresson
  • Matthias Von Herrath
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 601)


Administration of autoantigens, especially via the mucosal route, can induce tolerance under certain circumstances. In autoimmune diabetes, mucosal vaccination with autoantigens was frequently effective in restoring tolerance in mice but has not yet succeeded in humans. Furthermore, in some instances, autoimmunity can be precipitated upon autoantigen administration. We will here briefly discuss the underlying reasons and delineate which efforts should be made in the future to rationally translate antigen-specific immunotherapy, for example, by establishing better assays to reduce the risk for possible adverse events in humans.


Major Histocompatibility Complex Class Oral Insulin Intranasal Insulin Fatal Anaphylaxis Mucosal Vaccination 
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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Georgia Fousteri
    • 1
  • Damien Bresson
    • 1
  • Matthias Von Herrath
    • 1
  1. 1.Department of Developmental ImmunologyLa Jolla Institute for Allergy and ImmunologyLa JollaUSA

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