Frequently Ill Children

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 601)


Frequently ill children (FIC) show persistence of infection in the nasopharynx, disbiosis of intestinal flora, and concomitant and allergic diseases. As per our results, FIC with acute respiratory diseases (ARD) frequency of 6–15 times a year plus chronic infection foci at the age of 2–15 y/o at the remission period have heterogeneous nature of immune system disorders. It depends on the age, frequency of ARD, and chronic infection foci. About 20–50% of children have low number of T cells and 70% of children have high number of activated T cells. About 5–23% of children have low level of serum IgG or IgA, while low level of saliva IgA has been determined in 94% of children and low synthesis of IFN-α in 80% and of IFN-γ in 30% of children. About 50% of kids have high level of common IgE (160–220 ME/ml) and diagnostic sensitization to various allergens. In contrast, only 25% of children with ARD frequency of 4–6 times a year without chronic infection foci had low synthesis of IFN-α , 30% had low IgA level in saliva, and 8.3% had low IgA level in serum. After vaccination against hepatitis B, antibody level to HBs-Ag and time of their circulation at FIC had been lower than in children with ARD frequency of 4–6 times a year. Examination of FIC at the remission period showed polymorphism of natural and adaptive immunity disorders associated with the immune system developmental delay and subsequent forming of chronic infection foci being an aggravating factor for these disorders.


Atopic Dermatitis Allergic Rhinitis Acute Respiratory Disease Remission Period Immune System Disorder 
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  1. Albickiy, V.Y. and Baranov, A.A. (1986) Frequently Ill Children: Clinical and SocialAspects. Saratov, Russia.Google Scholar
  2. Ershov, F.I. (2005) Interferons and their Inductors. Goatar-Media Publishing, Moscow, Russia.Google Scholar
  3. Hewson-Bower, B. and Drummond, P.D. (1996) Secretory immunoglobulin A increases during relaxation in children with and without recurrent upper respiratory infections. J. Dev. Behav. Pediatr. 17, 311–316.CrossRefPubMedGoogle Scholar
  4. Holt, P.G. and Sly, P.D. (2002) Interactions between RSV infection, asthma, and atopy: unraveling the complexities. J. Exp. Med. 196, 1271–1275.CrossRefPubMedGoogle Scholar
  5. Khaitov, R.M., Pinegin, B.V. and Istamov, H.I. (1995) Ecological Immunology. VNIRO Publishing, Moscow, Russia.Google Scholar
  6. Makarova, Z.S. (2005) Frequently ill children and their rehabilitation at pediatric polyclinic. Polyclinic (Russ.) 14, 19.Google Scholar
  7. Mancini, C., Iacovani, R. and Fiermonte, V. (1996) Evaluation of serum IgG subclasses at children with recurrent respiratory infections. Minerva Pediatr. 48, 79–83.PubMedGoogle Scholar
  8. Markova, T.P., Chuvirov, D.G. and Chuvirov, G.N. (2003) Children getting ill frequently and for a long time. In: Clinical Immunolology and Allergy Medicine.Ed. Gianni Marone. JGC Publishing, Naples, Italy. 62, 425–429.Google Scholar
  9. Markova, T.P., Khaitov, R.M. and Tchouvirov, G.N. (1997) Methodological approaches to immunological diagnosis. Immunol. Lett. 56, 332.Google Scholar
  10. Markova, T.P. and Kharianova, M.E. (2001) Postvaccinal immunity forcing at frequently and lasting ill children. Allergy Asthma Clin. Immunol. 1, 75–77.Google Scholar
  11. Namazova, A.S., Botvinjeva, V.V. and Torchoeva, R.M. (2005) Frequently ill children of megapolysis. Pediatr. Pharmacol. 2, 3–7.Google Scholar

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© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  1. 1.Federal Educational Establishment Advanced Study Institute, FMBAMoscowRussia

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