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Serum Levels of Soluble HLA and IL-2R Molecules in Patients with Urogenital Chlamydia Infection

  • Victor V. Novikov
  • Natalya I. Egorova
  • Georgii Yu. Kurnikov
  • Irina V. Evsegneeva
  • Anatoly Yu. Baryshnikov
  • Alexandr V. Karaulov
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 601)

Abstract

Cellular immunity plays a central role in immune response to chlamydial infection, and soluble forms of immune cell membrane antigens take part in the regulation of immune response. Using an immunoenzymatic method, we determined serum levels of soluble HLA molecules (sHLA-I and sHLA-DR) and soluble CD25 molecules (sCD25) in patients with genital chlamydial infection. Specimens from patients with nonspecific inflammation of the urogenital tract were studied and healthy volunteers served as controls. We revealed that serum levels of sHLA-DR and sCD25 increased 3.5- and 2.3-fold, respectively, during chlamydial infection, while the levels of sHLA-I were not changed. Nonspecific inflammation of the urogenital tract was characterized by a 1.5-fold increase in sHLA-I, a 1.6-fold decrease in sCD25, and no changes of sHLA-DR levels in comparison with healthy volunteers. We concluded that Th1 immune responses might dominate during genital chlamydial infection contrary to the state of nonspecific inflammation of urogenital tract.

Keywords

Chlamydia Trachomatis Chlamydial Infection Urogenital Tract Active Pulmonary Tuberculosis Serum sCD25 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Victor V. Novikov
    • 1
  • Natalya I. Egorova
    • 1
  • Georgii Yu. Kurnikov
    • 1
  • Irina V. Evsegneeva
    • 2
  • Anatoly Yu. Baryshnikov
    • 3
  • Alexandr V. Karaulov
    • 2
  1. 1.N.I. Lobachevsky State University of Nizhny NovgorodRussia
  2. 2.I.M. Sechenov Medical Academy of MoscowRussia
  3. 3.N.N. Blohin Russian Oncological Scientific CentreMascowRussia

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