Abstract
Cellular immunity plays a central role in immune response to chlamydial infection, and soluble forms of immune cell membrane antigens take part in the regulation of immune response. Using an immunoenzymatic method, we determined serum levels of soluble HLA molecules (sHLA-I and sHLA-DR) and soluble CD25 molecules (sCD25) in patients with genital chlamydial infection. Specimens from patients with nonspecific inflammation of the urogenital tract were studied and healthy volunteers served as controls. We revealed that serum levels of sHLA-DR and sCD25 increased 3.5- and 2.3-fold, respectively, during chlamydial infection, while the levels of sHLA-I were not changed. Nonspecific inflammation of the urogenital tract was characterized by a 1.5-fold increase in sHLA-I, a 1.6-fold decrease in sCD25, and no changes of sHLA-DR levels in comparison with healthy volunteers. We concluded that Th1 immune responses might dominate during genital chlamydial infection contrary to the state of nonspecific inflammation of urogenital tract.
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References
Aultman, D., Adamashvili, I., Yaturu, K., Langford, M., Gelder, F., Gautreaux, M., Ghali, G.E. and McDonald, J. (1999) Soluble HLA in human body fluids. Hum. Immunol. 60, 239–244.
Bevilacqua, M.P. (1993) Endothelial-leukocyte adhesion molecules. Annu. Rev. Immunol. 11, 767–804.
Bhushan, R., Kirkham, C., Sethi, S. and Murphy, T.F. (1997) Antigenic characterization and analysis of the human immune response to outer membrane protein E of Branhamella catarrhalis. Infect. Immun. 65, 2668–2675.
Bilinska, M., Frydecka, I. and Podemski, R. (2001) [Clinical course and changes of soluble interleukin-2 receptor and soluble forms of intercellular adhesion molecule-1 (ICAM-1) in serum of multiple sclerosis patients]. Neurol. Neurochir. Pol. 35, 47–56.
Brieva, J.A., Villar, L.M., Leoro, G., Alvarez-Cermeno, J.C., Roldan, E. and Gonzalez-Porque, P. (1990) Soluble HLA class I antigen secretion by normal lymphocytes: relationship with cell activation and effect of interferon-gamma. Clin. Exp. Immunol 82, 390–395.
Carbone, E., Terrazzano, G., Colonna, M., Tuosto, L., Piccolella, E., Franksson, L., Palazzolo, G., Perez-Villar, J.J., Fontana, S., Karre, K. and Zappacosta, S. (1996) Natural killer clones recognize specific soluble HLA class I molecules. Eur. J. Immunol. 26, 683–689.
Claus, R., Bittorf, T., Walzel, H., Brock, J., Uhde, R., Meiske, D., Schulz, U., Hobusch, D., Schumacher, K., Witt, M., Bartel, F. and Hausmann, S. (2000) High concentration of soluble HLA-DR in the synovial fluid: generation and significance in “rheumatoid-like” inflammatory joint diseases. Cell. Immunol. 206, 85–100.
Dummer, R., Posseckert, G., Nestle, F., Witzgall, R., Burger, M., Becker, J.C., Schafer, E., Wiede, J., Sebald, W. and Burg, G. (1992) Soluble interleukin-2 receptors inhibit interleukin 2-dependent proliferation and cytotoxicity: explanation for diminished natural killer cell activity in cutaneous T-cell lymphomas in vivo? J. Invest. Dermatol. 98, 50–54.
Egorova, N.I., Kurnikov, G.Y., Babaev, A.A. and Novikov, V.V. (2003) Serum level of soluble molecules of intercellular adhesion in urogenital chlamidiosis. Cytokines Inflamm. 2, 32–36.
Igietseme, J.U., Magee, D.M., Williams, D.M. and Rank, R.G. (1994) Role for CD8+ T cells in antichlamydial immunity defined by Chlamydia-specific T-lymphocyte clones. Infect. Immun. 62, 5195–5197.
Inostroza, J., Munoz, P., Espinoza, R., Millaqueo, L., Diaz, P., Leiva, L. and Sorensen, R. (1994) Quantitation of soluble HLA class I heterodimers and beta 2-microglobulin in patients with active pulmonary tuberculosis. Hum. Immunol. 40, 179–182.
Lebedev, M.J., Krizhanova, M.A., Vilkov, S.A., Sholkina, M.N., Vyasmina, E.S., Baryshnikov, A. and Novikov, V.V. (2003) Peripheral blood lymphocytes immunophenotype and serum concentration of soluble HLA class I in burn patients. Burns 29, 123–128.
Moore, C., Ehlayel, M., Inostroza, J., Leiva, L.E. and Sorensen, R.U. (1997) Elevated levels of soluble HLA class I (sHLA-I) in children with severe atopic dermatitis. Ann. Allergy Asthma Immunol. 79, 113–118.
Morrison, R.P. and Caldwell, H.D. (2002) Immunity to murine chlamydial genital infection. Infect. Immun. 70, 2741–2751.
Ojcius, D.M., Bravo de Alba, Y., Kanellopoulos, J.M., Hawkins, R.A., Kelly, K.A., Rank, R.G. and Dautry-Varsat, A. (1998) Internalization of Chlamydia by dendritic cells and stimulation of Chlamydia-specific T cells. J. Immunol. 160, 1297–1303.
Starnbach, M.N., Bevan, M.J. and Lampe, M.F. (1994) Protective cytotoxic T lymphocytes are induced during murine infection with Chlamydia trachomatis. J. Immunol. 153, 5183–5189.
Su, H. and Caldwell, H.D. (1995) CD4+ T cells play a significant role in adoptive immunity to Chlamydia trachomatis infection of the mouse genital tract. Infect. Immun. 63, 3302–3308.
Symons, J.A., Wood, N.C., Di Giovine, F.S. and Duff, G.W. (1988) Soluble IL-2 receptor in rheumatoid arthritis. Correlation with disease activity, IL-1 and IL-2 inhibition. J. Immunol. 141, 2612–2618.
Vyasmina, E.S., Ptytsina, Y.S., Matveeva, E.M., Komarova, V.D., Barysnikov, AY. and Novikov, V.V. (2001) Soluble forms of HLA class I in HIV-infected persons and patients with syphilis and/or hepatitis C. Russ. J. HIV/AIDS Relat. Probl. 5, 136–137.
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Novikov, V.V., Egorova, N.I., Kurnikov, G.Y., Evsegneeva, I.V., Baryshnikov, A.Y., Karaulov, A.V. (2007). Serum Levels of Soluble HLA and IL-2R Molecules in Patients with Urogenital Chlamydia Infection. In: Shurin, M.R., Smolkin, Y.S. (eds) Immune-Mediated Diseases. Advances in Experimental Medicine and Biology, vol 601. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72005-0_30
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DOI: https://doi.org/10.1007/978-0-387-72005-0_30
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