Natural Killer T (NKT) Cell Subsets in Chlamydial Infections

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 601)


Natural killer T (NKT) cells are a newly identified unique subset of cells that express both α β T cell receptor and NK cell markers. We investigated the role of NKT cells in modulating adaptive T cell responses in chlamydial infections using human-disease-related chlamydial species. Our study provides in vivo evidence that even closely related pathogens may activate different functional NKT subsets, which can further polarize CD4+ and CD8+ cells in adaptive immune responses.


Chlamydial Infection Intracellular Cytokine Staining Cytokine Pattern Related Pathogen CD1d Tetramer 
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© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  1. 1.Laboratory for Infection and Immunity, Departments of Medical Microbiology and ImmunologyUniversity of ManitobaWinnipegCanada

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