Myeloid-Derived Suppressor Cells
The development of tumor-specific T cell tolerance is largely responsible for tumor escape. Accumulation of myeloid-derived suppressor cells (MDSCs) in animal tumor models as well as in cancer patients is involved in tumor-associated T cell tolerance. In recent years, it has become increasingly evident that MDSCs bring about antigen-specific T cell tolerance by various mechanisms, which is the focus of this chapter.
KeywordsMyeloid Cell Arginase Activity Cell Tolerance Tumor Escape Immature Myeloid Cell
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