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Myeloid-Derived Suppressor Cells

  • Srinivas Nagaraj
  • Dmitry I. Gabrilovich
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 601)

Abstract

The development of tumor-specific T cell tolerance is largely responsible for tumor escape. Accumulation of myeloid-derived suppressor cells (MDSCs) in animal tumor models as well as in cancer patients is involved in tumor-associated T cell tolerance. In recent years, it has become increasingly evident that MDSCs bring about antigen-specific T cell tolerance by various mechanisms, which is the focus of this chapter.

Keywords

Myeloid Cell Arginase Activity Cell Tolerance Tumor Escape Immature Myeloid Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  1. 1.H. Lee Moffitt Cancer Center, University of South FloridaTampaUSA

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