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Photobiomodulation by Low Power Laser Irradiation Involves Activation of Latent TGF-β1

  • Conference paper
Proceedings of Light-Activated Tissue Regeneration and Therapy Conference

Part of the book series: Lecture Notes in Electrical Engineering ((LNEE,volume 12))

Abstract

Laser mediated stimulation of biological process was amongst its very first effects documented by Mester et al. but the ambiguous and tissue-cell context specific biological effects of laser radiation is now termed ‘Photobiomodulation’. We found many parallels between the reported biological effects of lasers and a multiface-ted growth factor, Transforming Growth Factor-β (TGF-β). This review outlines the interestingparallelsbetween the twofieldsand our rationalefor pursuingtheir potential causal correlation. We explored this correlation using an in vitro assay systems and a human clinical trial on healing wound extraction sockets that we reported in a recent publication. In conclusion we report that low power laser irradiation can activate latent TGF-β1 and β3 complexes and suggest that this might be one of the major modes of the photobiomodulatory effects of low power lasers.

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Authors and Affiliations

  1. Programs in Oral and Maxillofacial Pathology, Biological Sciences in Dental Medicine and Leder Medical Sciences, Harvard School of Dental Medicine, Boston, MA, USA

    Praveen R. Arany

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  1. Praveen R. Arany
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Editors and Affiliations

  1. U.S. Food and Drug Administration, Center for Devices and Radiological Health, White Oak, MD, USA

    Ronald Waynant  & Darrell B. Tata  & 

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Arany, P.R. (2008). Photobiomodulation by Low Power Laser Irradiation Involves Activation of Latent TGF-β1. In: Waynant, R., Tata, D.B. (eds) Proceedings of Light-Activated Tissue Regeneration and Therapy Conference. Lecture Notes in Electrical Engineering, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-71809-5_19

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  • DOI: https://doi.org/10.1007/978-0-387-71809-5_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-71808-8

  • Online ISBN: 978-0-387-71809-5

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