Abstract
Coronary artery disease, which may lead to myocardial infarction (MI), is the primary cause of mortality world-wide. In a series of studies in which the rat and canine models were used, the effect of LLLT on infarct size after chronic myocardial infarction in rats was investigated. LLLT caused a profound (50–70%) reduction in infarct size and ventricular dilatation in the rat heart after chronic MI. This phenomenon was achieved by the cardioprotective effect of LLLT on mitochondria, elevation of cytoprotective heat shock proteins and enhanced angiogenesis in the myocardium following laser irradiation. The effect of LLLT on the expression of vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase (iNOS) in the infarcted heart was also investigated. It was found that VGEF and iNOS expression in the infarcted rat heart is markedly upregulated by LLLT and is associated with enhanced angiogenesis and cardioprotection. The possible beneficial effects on implantation of autologeous mesenchymal stem cells (MSCs) that had been laser irradiated prior to their implantation into the infarcted rat heart was also investigated. These findings provided the first evidence that LLLT can significantly increase survival and/or proliferation of MSCs post implanation into the ischemic/ infarcted heart, followed by a marked reduction of scarring, and enhanced angio-genesis. The results of the animal studies may also have clinical relevance. It can be postulated that the use of laser following MI is most probably safe and our observations indicate that delivery of laser energy to the heart may have an important beneficial effect on patients after acute MI or ischemic heart conditions.
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References
Losordo DW, Vale PR, Symes JF, Dunnington CH, Esakof DD, Maysky M, Ashare AB, Lathi K, Isner JM. Gene therapy for myocardial angiogenesis: initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia. Circulation 1998; 98:2800–2804.
Yaakov N, Bdolah A, Wolberg Z, Ben-Haim S, Oron U. Recovery from sarafotoxin-b induced cardiopathological effects in mice following low energy laser irradiation. Basic Res Cardiol 2000; 95:385–389.
Yaakobi T, Shoshani Y, Levkovitz S, Rubin O, Ben-Haim SA, Oron U. Long term effect of low energy laser irradiation on infarction and reperfusion injury in the rat heart. J Appl Physiol 2001; 90:2411–2419.
Oron U, Yaakobi T, Oron A, Mordechovitz D, Shofti R, Hayam G, Dror U, Gepstein L, Wolf T, Haudenschild C, Ben Haim SA. Low energy laser irradiation reduces formation of scar tissue following myocardial infarction in dogs. Circulation 2001; 103:296–301.
Oron U, Yaakobi T, Oron A, Hayam G, Gepstein L, Wolf T, Rubin O, and Ben Haim SA. Attenuation of the formation of scar tissue in rats and dogs post myocardial infarction by low energy laser irradiation. Lasers Surg Med 2001; 28:204–211.
Oron U. Photoengineering of tissue repair in skeletal and cardiac muscles. Photomed Laser Surg 2006; 24:111–120. Review.
Ben-Dov N, Shefer G, Irinitchev A, Wernig A, Oron U, Halevy O. Low-energy laser irradiation affects satellite cell proliferation and differentiation in vitro. Biochim Biophys Acta 1999; 1448:372–381.
Shefer G, Oron U, Irintchev A, Wernig A, Halevy O. Skeletal muscle cell activation by low energy laser irradiation: a role for the MAP/ERK pathway. J Cell Physiol 2001; 187:73–80.
Ilic S, Leichliter S, Streeter J, Oron A, DeTaboada L, Oron U. Effects of power densities, continuous and pulse frequencies, and number of sessions of low-level laser therapy on intact rat brain. Photomed Laser Surg 2006; 24(4):458–466.
Tuner J, Hode L. Low level laser therapy — clinical practice and scientific background. Grangesberg, Sweden: Prima Book in Sweden AB. 1999.
Tuby H, Maltz L, Oron U. Modulations of VEGF and iNOS in the rat heart by low level laser therapy are associated with cardioprotection and enhanced angiogenesis. Laser Surg Med 2006; 38:682–688.
Zachary I, Gliki G. Signaling transduction mechanisms mediating biological action of the vascular endothelial growth factor family. Cardiovascular Res 2001; 49:568–581.
Dawn B, Bolli R. Role of nitric oxide in myocardial preconditioning. Ann NY Sci 2002; 962:18–41.
Li Q, Guo Y, Tan W, Stein AB, Dawn B, Wu WJ, Zhu X, Lu X, Xu X, Siddiqui T, Tiwari S, Bolli R. Gene therapy with inducible nitric oxide synthase provides long-term protection against myocardial provides long term protection against myocardial infarction without adverse functional consequences. Am J Physiol 2006; 290:584–589.
Rumyantsev PP. Interrelations of the proliferation and differentiation processes during cardiac myogenesis and regeneration. Int Rev Cytol 1977; 51:186–273. Review.
Harsdorf R.Von, P Poole-Wilson, R Dietz. Regenerative capacity of the myocardium: implications for treatment of heart failure. Lancet 2004; 363:1306–1313.
Thom T, Haase N, Rosamond W, Howard VJ, Rumsfeld J, Manolio T, Zheng ZJ, Flegal K, O'Donnell C, Kittner S, Lloyd-Jones D, Goff DC, Jr. Hong Y. Heart disease and stroke statistics — 2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2006; 113:85–151.
Anversa P, Fitzpatrick D, Argani S, Capasso JM. Myocyte mitotic division in the aging mammalian rat heart. Circ Res 1991; 69(4):1159–1164.
Beltrami AP, Barlucchi L, Torella D, Baker M, Limana F, Chimenti S, Kasahara H, Rota M, Musso E, Urbanek K, Leri A, Kajstura J, Nadal-Ginard B, Anversa P. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 2003; 114(6):763–776.
Wang QD, Sjoquist PO. Myocardial regeneration with stem cells: pharmacological possibilities for efficacy enhancement. Pharmacol Res 2006; 53:331–340.
Dawn B. and R Bolli. Adult bone marrow-derived cells: regenerative potential, plasticity, and tissue commitment. Basic Res Cardiol 2005; 100:494–503.
Schachinger V, Erbs S, Elsasser A, Haberbosch W, Hambrecht R, Hölschermann H, Yu J, Corti R, Mathey DG, Hamm CW, Süselbeck T, Assmus B, Tonn T, Dimmeler S, Zeiher AM. REPAIR-AMI Investigators. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med 2006; 355(12):1210–1221.
Stamm C, Kleine HD, Choi YH, Dunkelmann S, Lauffs JA, Lorenzen B, David A, Liebold A, Nienaber C, Zurakowski D, Freund M, Steinhoff G. Intramyocardial delivery of CD133+ marrow cells and coronary artery bypass grafting for chronic ischemic heart disease: safety and efficacy studies. J Thora Cardiovas Surg 2007; 133(3):717–725.
Rosenzweig A. Cardiac cell therapy — mixed results from mixed cells. N Eng J Med 2006; 355:1274–1277.
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Tuby, H., Maltz, L., Oron, U. (2008). Light Therapy for the Cardiovascular System. In: Waynant, R., Tata, D.B. (eds) Proceedings of Light-Activated Tissue Regeneration and Therapy Conference. Lecture Notes in Electrical Engineering, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-71809-5_14
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DOI: https://doi.org/10.1007/978-0-387-71809-5_14
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