Advertisement

Structural Insight into Natural Killer T Cell Receptor Recognition of CD1d

  • Natalie A. Borg
  • Lars Kjer-Nielsen
  • James McCluskey
  • Jamie Rossjohn
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 598)

Keywords

Natural Killer iNKT Cell Human CD1d Mouse CD1d Cell Receptor Recognition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Benlagha, K., Weiss, A., Beavis, A., Teyton, L. & Bendelac, A., 2000, In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers, J Exp Med. 191:1895-903.PubMedCrossRefGoogle Scholar
  2. Borg, N.A., Ely, L.K., Beddoe, T., Macdonald, W.A., Reid, H.H., Clements, C.S., Purcell, A.W., Kjer-Nielsen, L., Miles, J.J., Burrows, S.R., McCluskey, J. & Rossjohn, J., 2005, The CDR3 regions of an immunodominant T cell receptor dictate the ‘energetic landscape’ of peptide-MHC recognition, Nat Immunol. 6:171-80.PubMedCrossRefGoogle Scholar
  3. Brigl, M., van den Elzen, P., Chen, X., Meyers, J.H., Wu, D., Wong, C.H., Reddington, F., Illarianov, P.A., Besra, G.S., Brenner, M.B. & Gumperz, J.E., 2006, Conserved and heterogeneous lipid antigen specificities of CD1d-restricted NKT cell receptors, J Immunol. 176:3625-34.PubMedGoogle Scholar
  4. Brossay, L., Chioda, M., Burdin, N., Koezuka, Y., Casorati, G., Dellabona, P. & Kronenberg, M., 1998, CD1d-mediated recognition of an alpha-galactosylceramide by natural killer T cells is highly conserved through mammalian evolution, J Exp Med. 188:1521-8.PubMedCrossRefGoogle Scholar
  5. Burdin, N., Brossay, L., Degano, M., Iijima, H., Gui, M., Wilson, I.A. & Kronenberg, M., 2000, Structural requirements for antigen presentation by mouse CD1, Proc Natl Acad Sci U S A. 97:10156-61.PubMedCrossRefGoogle Scholar
  6. Cantu, C., 3rd, Benlagha, K., Savage, P.B., Bendelac, A. & Teyton, L., 2003, The paradox of immune molecular recognition of alpha-galactosylceramide: low affinity, low specificity for CD1d, high affinity for alpha beta TCRs, J Immunol. 170:4673-82.PubMedGoogle Scholar
  7. Clements, C.S., Dunstone, M.A., Macdonald, W.A., McCluskey, J. & Rossjohn, J., 2006, Specificity on a knife-edge: the alphabeta T cell receptor, Curr Opin Struct Biol.Google Scholar
  8. Crowe, N.Y., Coquet, J.M., Berzins, S.P., Kyparissoudis, K., Keating, R., Pellicci, D.G., Hayakawa, Y., Godfrey, D.I. & Smyth, M.J., 2005, Differential antitumor immunity mediated by NKT cell subsets in vivo, J Exp Med. 202:1279-88.PubMedCrossRefGoogle Scholar
  9. Ely, L.K., Kjer-Nielsen, L., McCluskey, J. & Rossjohn, J., 2005, Structural studies on the alphabeta T-cell receptor, IUBMB Life. 57:575-82.PubMedCrossRefGoogle Scholar
  10. Fischer, K., Scotet, E., Niemeyer, M., Koebernick, H., Zerrahn, J., Maillet, S., Hurwitz, R., Kursar, M., Bonneville, M., Kaufmann, S.H. & Schaible, U.E., 2004, Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells, Proc Natl Acad Sci U S A. 101:10685-90.PubMedCrossRefGoogle Scholar
  11. Gadola, S.D., Dulphy, N., Salio, M. & Cerundolo, V., 2002, Valpha24-JalphaQ-independent, CD1d-restricted recognition of alpha-galactosylceramide by human CD4(+) and CD8alphabeta(+) T lymphocytes, J Immunol. 168:5514-20.PubMedGoogle Scholar
  12. Gadola, S.D., Koch, M., Marles-Wright, J., Lissin, N.M., Shepherd, D., Matulis, G., Harlos, K., Villiger, P.M., Stuart, D.I., Jakobsen, B.K., Cerundolo, V. & Jones, E.Y., 2006, Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors, J Exp Med. 203:699-710.PubMedCrossRefGoogle Scholar
  13. Giabbai, B., Sidobre, S., Crispin, M.D., Sanchez-Ruiz, Y., Bachi, A., Kronenberg, M., Wilson, I.A. & Degano, M., 2005, Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation, J Immunol. 175:977-84.PubMedGoogle Scholar
  14. Goff, R.D., Gao, Y., Mattner, J., Zhou, D., Yin, N., Cantu, C., 3rd, Teyton, L., Bendelac, A. & Savage, P.B., 2004, Effects of lipid chain lengths in alpha-galactosylceramides on cytokine release by natural killer T cells, J Am Chem Soc. 126:13602-3.PubMedCrossRefGoogle Scholar
  15. Hammond, K.J., Pelikan, S.B., Crowe, N.Y., Randle-Barrett, E., Nakayama, T., Taniguchi, M., Smyth, M.J., van Driel, I.R., Scollay, R., Baxter, A.G. & Godfrey, D.I., 1999, NKT cells are phenotypically and functionally diverse, Eur J Immunol. 29:3768-81.PubMedCrossRefGoogle Scholar
  16. Kamada, N., Iijima, H., Kimura, K., Harada, M., Shimizu, E., Motohashi, S., Kawano, T., Shinkai, H., Nakayama, T., Sakai, T., Brossay, L., Kronenberg, M. & Taniguchi, M., 2001, Crucial amino acid residues of mouse CD1d for glycolipid ligand presentation to V(alpha)14 NKT cells, Int Immunol. 13:853-61.PubMedCrossRefGoogle Scholar
  17. Kang, S.J. & Cresswell, P., 2004, Saposins facilitate CD1d-restricted presentation of an exogenous lipid antigen to T cells, Nat Immunol. 5:175-81.PubMedCrossRefGoogle Scholar
  18. Kawano, T., Cui, J., Koezuka, Y., Toura, I., Kaneko, Y., Motoki, K., Ueno, H., Nakagawa, R., Sato, H., Kondo, E., Koseki, H. & Taniguchi, M., 1997, CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides, Science. 278:1626-9.PubMedCrossRefGoogle Scholar
  19. Kinjo, Y., Tupin, E., Wu, D., Fujio, M., Garcia-Navarro, R., Benhnia, M.R., Zajonc, D.M., Ben-Menachem, G., Ainge, G.D., Painter, G.F., Khurana, A., Hoebe, K., Behar, S.M., Beutler, B., Wilson, I.A., Tsuji, M., Sellati, T.J., Wong, C.H. & Kronenberg, M., 2006, Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria, Nat Immunol. 7:978-86.PubMedCrossRefGoogle Scholar
  20. Kinjo, Y., Wu, D., Kim, G., Xing, G.W., Poles, M.A., Ho, D.D., Tsuji, M., Kawahara, K., Wong, C.H. & Kronenberg, M., 2005, Recognition of bacterial glycosphingolipids by natural killer T cells, Nature. 434:520-5.PubMedCrossRefGoogle Scholar
  21. Kjer-Nielsen, L., Borg, N.A., Pellicci, D.G., Beddoe, T., Kostenko, L., Clements, C.S., Williamson, N.A., Smyth, M.J., Besra, G.S., Reid, H.H., Bharadwaj, M., Godfrey, D.I., Rossjohn, J. & McCluskey, J., 2006, A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition, J Exp Med. 203:661-73.PubMedCrossRefGoogle Scholar
  22. Koch, M., Stronge, V.S., Shepherd, D., Gadola, S.D., Mathew, B., Ritter, G., Fersht, A.R., Besra, G.S., Schmidt, R.R., Jones, E.Y. & Cerundolo, V., 2005, The crystal structure of human CD1d with and without alpha-galactosylceramide, Nat Immunol. 6:819-26.PubMedCrossRefGoogle Scholar
  23. Lantz, O. & Bendelac, A., 1994, An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans, J Exp Med. 180:1097-106.PubMedCrossRefGoogle Scholar
  24. Macdonald, W.A., Purcell, A.W., Mifsud, N.A., Ely, L.K., Williams, D.S., Chang, L., Gorman, J.J., Clements, C.S., Kjer-Nielsen, L., Koelle, D.M., Burrows, S.R., Tait, B.D., Holdsworth, R., Brooks, A.G., Lovrecz, G.O., Lu, L., Rossjohn, J. & McCluskey, J., 2003, A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire, and T cell recognition, J Exp Med. 198:679-91.PubMedCrossRefGoogle Scholar
  25. Matsuda, J.L., Gapin, L., Fazilleau, N., Warren, K., Naidenko, O.V. & Kronenberg, M., 2001, Natural killer T cells reactive to a single glycolipid exhibit a highly diverse T cell receptor beta repertoire and small clone size, Proc Natl Acad Sci U S A. 98:12636-41.PubMedCrossRefGoogle Scholar
  26. Mattner, J., Debord, K.L., Ismail, N., Goff, R.D., Cantu, C., 3rd, Zhou, D., Saint-Mezard, P., Wang, V., Gao, Y., Yin, N., Hoebe, K., Schneewind, O., Walker, D., Beutler, B., Teyton, L., Savage, P.B. & Bendelac, A., 2005, Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections, Nature. 434:525-9.PubMedCrossRefGoogle Scholar
  27. Mercer, J.C., Ragin, M.J. & August, A., 2005, Natural killer T cells: rapid responders controlling immunity and disease, Int J Biochem Cell Biol. 37:1337-43.PubMedCrossRefGoogle Scholar
  28. Miyamoto, K., Miyake, S. & Yamamura, T., 2001, A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells, Nature. 413:531-4.PubMedCrossRefGoogle Scholar
  29. Nieda, M., Okai, M., Tazbirkova, A., Lin, H., Yamaura, A., Ide, K., Abraham, R., Juji, T., Macfarlane, D.J. & Nicol, A.J., 2004, Therapeutic activation of Valpha24+Vbeta11+ NKT cells in human subjects results in highly coordinated secondary activation of acquired and innate immunity, Blood. 103:383-9.PubMedCrossRefGoogle Scholar
  30. Ortaldo, J.R., Young, H.A., Winkler-Pickett, R.T., Bere, E.W., Jr., Murphy, W.J. & Wiltrout, R.H., 2004, Dissociation of NKT stimulation, cytokine induction, and NK activation in vivo by the use of distinct TCR-binding ceramides, J Immunol. 172:943-53.PubMedGoogle Scholar
  31. Parekh, V.V., Singh, A.K., Wilson, M.T., Olivares-Villagomez, D., Bezbradica, J.S., Inazawa, H., Ehara, H., Sakai, T., Serizawa, I., Wu, L., Wang, C.R., Joyce, S. & Van Kaer, L., 2004, Quantitative and qualitative differences in the in vivo response of NKT cells to distinct alpha- and beta-anomeric glycolipids, J Immunol. 173:3693-706.PubMedGoogle Scholar
  32. Schumann, J., Voyle, R.B., Wei, B.Y. & MacDonald, H.R., 2003, Cutting edge: influence of the TCR V beta domain on the avidity of CD1d:alpha-galactosylceramide binding by invariant V alpha 14 NKT cells, J Immunol. 170:5815-9.PubMedGoogle Scholar
  33. Sidobre, S., Naidenko, O.V., Sim, B.C., Gascoigne, N.R., Garcia, K.C. & Kronenberg, M., 2002, The V alpha 14 NKT cell TCR exhibits high-affinity binding to a glycolipid/CD1d complex, J Immunol. 169:1340-8.PubMedGoogle Scholar
  34. Sriram, V., Du, W., Gervay-Hague, J. & Brutkiewicz, R.R., 2005, Cell wall glycosphingolipids of Sphingomonas paucimobilis are CD1d-specific ligands for NKT cells, Eur J Immunol. 35:1692-701.PubMedCrossRefGoogle Scholar
  35. Wu, D., Xing, G.W., Poles, M.A., Horowitz, A., Kinjo, Y., Sullivan, B., Bodmer-Narkevitch, V., Plettenburg, O., Kronenberg, M., Tsuji, M., Ho, D.D. & Wong, C.H., 2005, Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells, Proc Natl Acad Sci U S A. 102:1351-6.PubMedCrossRefGoogle Scholar
  36. Wu, D., Zajonc, D.M., Fujio, M., Sullivan, B.A., Kinjo, Y., Kronenberg, M., Wilson, I.A. & Wong, C.H., 2006, Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d, Proc Natl Acad Sci U S A. 103:3972-7.PubMedCrossRefGoogle Scholar
  37. Wu, D.Y., Segal, N.H., Sidobre, S., Kronenberg, M. & Chapman, P.B., 2003, Cross-presentation of disialoganglioside GD3 to natural killer T cells, J Exp Med. 198:173-81.PubMedCrossRefGoogle Scholar
  38. Yu, K.O., Im, J.S., Molano, A., Dutronc, Y., Illarionov, P.A., Forestier, C., Fujiwara, N., Arias, I., Miyake, S., Yamamura, T., Chang, Y.T., Besra, G.S. & Porcelli, S.A., 2005, Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of alpha-galactosylceramides, Proc Natl Acad Sci U S A. 102:3383-8.PubMedCrossRefGoogle Scholar
  39. Zajonc, D.M., Ainge, G.D., Painter, G.F., Severn, W.B. & Wilson, I.A., 2006, Structural characterization of mycobacterial phosphatidylinositol mannoside binding to mouse CD1d, J Immunol. 177:4577-83.Google Scholar
  40. Zajonc, D.M., Cantu, C., 3rd, Mattner, J., Zhou, D., Savage, P.B., Bendelac, A., Wilson, I.A. & Teyton, L., 2005a, Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor, Nat Immunol. 6:810-8.CrossRefGoogle Scholar
  41. Zajonc, D.M., Maricic, I., Wu, D., Halder, R., Roy, K., Wong, C.H., Kumar, V. & Wilson, I.A., 2005b, Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity, J Exp Med. 202:1517-26.CrossRefGoogle Scholar
  42. Zhou, D., Mattner, J., Cantu, C., 3rd, Schrantz, N., Yin, N., Gao, Y., Sagiv, Y., Hudspeth, K., Wu, Y.P., Yamashita, T., Teneberg, S., Wang, D., Proia, R.L., Levery, S.B., Savage, P.B., Teyton, L. & Bendelac, A., 2004, Lysosomal glycosphingolipid recognition by NKT cells, Science. 306:1786-9.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Natalie A. Borg
    • 1
  • Lars Kjer-Nielsen
    • 2
  • James McCluskey
    • 2
  • Jamie Rossjohn
    • 1
  1. 1.Protein Crystallography Unit, Department of Biochemistry and Molecular BiologyMonash UniversityVictoriaAustralia, 3800
  2. 2.Department of Microbiology and ImmunologyThe University of MelbourneVictoriaAustralia, 3800

Personalised recommendations