• Pierre D. J. Moens
Part of the Protein Reviews book series (PRON, volume 8)

Profilin, a small ubiquitous nonmuscle protein of 12–14 kDa, is found in eukaryotic cells (Carlsson et al. 1977; Reichstein and Korn 1979) including plants (Valenta et al. 1992), and viruses (Machesky et al. 1994) (see chapter by Bearer). It is expressed in all eukaryotic organisms studied to date. Profilin is essential for the normal development and cytokinesis of Dictyostelium Amoeba (Haugwitz et al. 1994). These authors showed that in profilin-null mutants cell motility was significantly reduced and development was blocked prior to fruiting body formation. Furthermore, these cells could not be grown in shaking culture under normal conditions.


Spinal Muscular Atrophy Actin Nucleation Mesangial Proliferative Glomerulonephritis Aldrich Syndrome Thymosin Beta 
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  1. Aldrich, R. A., Steinberg, A. G. and Campbell, D. C. 1954. Pedigree demonstrating a sex-linked recessive condition characterized by draining ears, eczematoid dermatitis and bloody diarrhea. Pediatrics 13, 133-139.PubMedGoogle Scholar
  2. Alekperova, G. A., Orudzhev, A. G. and Javadov, S. A. 2004. Analysis of erythrocyte and platelet membrane proteins in various forms of beta-Thalassemia. Biochemistry 69, 748-753.PubMedGoogle Scholar
  3. Bae, Y. S., Cantley, L. G., Chen, C. S., Kim, S. R., Kwon, K. S. and Rhee, S. G. 1998. Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 273, 4465-4469.CrossRefPubMedGoogle Scholar
  4. Basso, M., Giraudo, S., Corpillo, D., Bergamasco, B., Lopiano, L. and Fasano, M. 2004. Proteome analysis of human substantia nigra in Parkinson’s disease. Proteomics 4, 3943-3952.CrossRefPubMedGoogle Scholar
  5. Belot, N., Pochet, R., Heizmann, C. W., Kiss, R. and Decaestecker, C. 2002. Extracellular S100A4 stimulates the migration rate of astrocytic tumor cells by modifying the organization of their actin cytoskeleton. Biochim. Biophys. Acta 1600,74-83.PubMedGoogle Scholar
  6. Bhargavi, V., Chari, V. B. and Singh, S. S. 1998. Phosphatidylinositol 3-kinase binds to profilin through the p85 alpha subunit and regulates cytoskeletal assembly. Biochem. Mol. Biol. Int. 46, 241-248.PubMedGoogle Scholar
  7. Boettner, B., Govek, E. E., Cross, J. and Van Aelst, L. 2000. The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin. Proc. Natl Acad. Sci. USA 97, 9064-9069.CrossRefPubMedGoogle Scholar
  8. Braun, A., Aszodi, A., Hellebrand, H., Berna, A., Fassler, R. and Brandau, O. 2002. Genomic organization of profilin-III and evidence for a transcript expressed exclusively in testis. Gene 283, 219-225.CrossRefPubMedGoogle Scholar
  9. Camera, P., da Silva, J. S., Griffiths, G., Giuffrida, M. G., Ferrara, L., Schubert, V., Imarisio, S., Silengo, L., Dotti, C. G. and Di Cunto, F. 2003. Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulation. Nat. Cell Biol. 5, 1071-1078.CrossRefPubMedGoogle Scholar
  10. Carlsson, L., Nystrom, L. E., Sundkvist, I., Markey, F. and Lindberg, U. 1977. Actin polymerizability is influenced by profilin, a low molecular weight protein in nonmuscle cells. J. Mol. Biol. 115, 465-483.CrossRefPubMedGoogle Scholar
  11. Chiurazzi, P., Neri, G. and Oostra, B. A. 2003. Understanding the biological underpinnings of fragile X syndrome. Curr. Opin. Pediatr. 15, 559-566.CrossRefPubMedGoogle Scholar
  12. Derry, J. M., Ochs, H. D. and Francke, U. 1994a. Isolation of a novel gene mutated in Wiskott-Aldrich syndrome. Cell 78, 635-644.CrossRefGoogle Scholar
  13. Derry, J. M., Ochs, H. D. and Francke, U. 1994b. Isolation of a novel gene mutated in Wiskott-Aldrich syndrome. Cell 79, following 922.Google Scholar
  14. Di Nardo, A., Gareus, R., Kwiatkowski, D. and Witke, W. 2000. Alternative splicing of the mouse profilin II gene generates functionally different profilin isoforms. J. Cell Sci. 113, 3795-3803.PubMedGoogle Scholar
  15. dos Remedios CG, Chhabra D, Kekic M, Dedova IV, Tsubakihara M, et al. 2003. Actin binding proteins: regulation of cytoskeletal microfilaments. Physiol. Rev. 83, 433-473.PubMedGoogle Scholar
  16. Fedorov, A. A., Ball, T., Mahoney, N. M., Valenta, R. and Almo, S. C. 1997. The molecular basis for allergen cross-reactivity: Crystal structure and IgE-epitope mapping of birch pollen profilin. Structure 5, 33-45.CrossRefPubMedGoogle Scholar
  17. Fedorov, A. A., Pollard, T. D. and Almo, S. C. 1994. Purification, characterization and crystallization of human platelet profilin expressed in Escherichia coli. J. Mol. Biol. 241, 480-482.CrossRefPubMedGoogle Scholar
  18. Gallego, M. D., Santamaria, M., Pena, J. and Molina, I. J. 1997. Defective actin reorganization and polymerization of Wiskott-Aldrich T cells in response to CD3-mediated stimulation. Blood 90, 3089-3097.PubMedGoogle Scholar
  19. Gambhir, A., Hangyas-Mihalyne, G., Zaitseva, I., Cafiso, D. S., Wang, J., Murray, D., Pentyala, S. N., Smith, S. O. and McLaughlin, S. 2004. Electrostatic sequestration of PIP2 on phospholipid membranes by basic/aromatic regions of proteins. Biophys. J. 86, 2188-2207.CrossRefPubMedGoogle Scholar
  20. Gertler, F. B., Niebuhr, K., Reinhard, M., Wehland, J. and Soriano, P. 1996. Mena, a relative of VASP and Drosophila enabled, is implicated in the control of microfilament dynamics. Cell 87, 227-239.CrossRefPubMedGoogle Scholar
  21. Giesemann, T., Rathke-Hartlieb, S., Rothkegel, M., Bartsch, J. W., Buchmeier, S., Jockusch, B. M. and Jockusch, H. 1999. A role for polyproline motifs in the spinal muscular atrophy protein SMN. Profilins bind to and colocalize with smn in nuclear gems. J. Biol. Chem. 274, 37908-37914.CrossRefPubMedGoogle Scholar
  22. Goldschmidt-Clermont, P. J., Furman, M. I., Wachsstock, D., Safer, D., Nachmias, V. T. and Pollard, T. D. 1992. The control of actin nucleotide exchange by thymosin beta 4 and profilin. A potential regulatory mechanism for actin polymerization in cells. Mol. Biol. Cell 3, 1015-1024.PubMedGoogle Scholar
  23. Goldschmidt-Clermont, P. J., Kim, J. W., Machesky, L. M., Rhee, S. G. and Pollard, T. D. 1991. Regulation of phospholipase C-gamma 1 by profilin and tyrosine phosphorylation. Science 251, 1231-1233.CrossRefPubMedGoogle Scholar
  24. Goldschmidt-Clermont, P. J., Machesky, L. M., Baldassare, J. J. and Pollard, T. D. 1990. The actin-binding protein profilin binds to PIP2 and inhibits its hydrolysis by phospholipase C. Science 247, 1575-1578.CrossRefPubMedGoogle Scholar
  25. Gutsche-Perelroizen, I., Lepault, J., Ott, A., Carlier, M. F. 1999. Filament assembly from profilin-actin. J. Biol. Chem. 274, 6234-6243.CrossRefPubMedGoogle Scholar
  26. Haleva, E., Ben-Tal, N. and Diamant, H. 2004. Increased concentration of polyvalent phospholipids in the adsorption domain of a charged protein. Biophys. J. 86, 2165-2178.CrossRefPubMedGoogle Scholar
  27. Hartwig, J. H., Chambers, K. A., Hopcia, K. L. and Kwiatkowski, D. J. 1989. Association of profilin with filament-free regions of human leukocyte and platelet membranes and reversible membrane binding during platelet activation. J. Cell Biol. 109,1571-1579.CrossRefPubMedGoogle Scholar
  28. Haugwitz, M., Noegel, A. A., Karakesisoglou, J. and Schleicher, M. 1994. Dictyostelium amoebae that lack G-actin-sequestering profilins show defects in F-actin content, cytokinesis, and development. Cell 79, 303-314.CrossRefPubMedGoogle Scholar
  29. Honore, B., Madsen, P., Andersen, A. H. and Leffers, H. 1993. Cloning and expression of a novel human profilin variant, profilin II. FEBS Lett. 330, 151-155.CrossRefPubMedGoogle Scholar
  30. Hu, E., Chen, Z., Fredrickson, T. and Zhu, Y. 2001. Molecular cloning and characterization of profilin-3: A novel cytoskeleton-associated gene expressed in rat kidney and testes. Exp. Nephrol. 9, 265-274.CrossRefPubMedGoogle Scholar
  31. Janke, J., Schluter, K., Jandrig, B., Theile, M., Kolble, K., Arnold, W., Grinstein, E., Schwartz, A., Estevez-Schwarz, L., Schlag, P. M., Jockusch, B. M. and Scherneck, S. 2000. Suppression of tumorigenicity in breast cancer cells by the microfilament protein profilin 1. J. Exp. Med. 191, 1675-1686.CrossRefPubMedGoogle Scholar
  32. Karakesisoglou, I., Schleicher, M., Gibbon, B. C. and Staiger, C. J. 1996. Plant profilins rescue the aberrant phenotype of profilin-deficient Dictyostelium cells. Cell Motil. Cytoskeleton 34, 36-47.CrossRefPubMedGoogle Scholar
  33. Kondo, T., Shirasawa, T., Itoyama, Y. and Mori, H. 1996. Embryonic genes expressed in Alzheimer’s disease brains. Neurosci. Lett. 209, 157-160.CrossRefPubMedGoogle Scholar
  34. Kwiatkowski, D. J., Aklog, L., Ledbetter, D. H. and Morton, C. C. 1990. Identification of the functional profilin gene, its localization to chromosome subband 17p13.3, and demonstration of its deletion in some patients with Miller-Dieker syndrome. Am. J. Hum. Genet. 46, 559-567.PubMedGoogle Scholar
  35. Lambrechts, A., Jonckheere, V., Dewitte, D., Vandekerckhove, J. and Ampe, C. 2002. Mutational analysis of human profilin I reveals a second PI(4,5)-P2 binding site neighbouring the poly(L-proline) binding site. BMC Biochem. 3, 12.CrossRefPubMedGoogle Scholar
  36. Lassing, I. and Lindberg, U. 1988. Specificity of the interaction between phosphatidylinositol 4,5-bisphosphate and the profilin:actin complex. J. Cell Biochem. 37,255-267.CrossRefPubMedGoogle Scholar
  37. Li, F. and Higgs, H. N. 2003. The mouse formin mDia1 is a potent actin nucleation factor regulated by autoinhibition. Curr. Biol. 13, 1335-1340.CrossRefPubMedGoogle Scholar
  38. Lu, P. J., Shieh, W. R., Rhee, S. G., Yin, H. L. and Chen, C. S. 1996. Lipid products of phosphoinositide 3-kinase bind human profilin with high affinity. Biochemistry 35,14027-14034.CrossRefPubMedGoogle Scholar
  39. Machesky, L. M., Cole, N. B., Moss, B. and Pollard, T. D. 1994. Vaccinia virus expresses a novel profilin with a higher affinity for polyphosphoinositides than actin. Biochemistry 33, 10815-10824.CrossRefPubMedGoogle Scholar
  40. Machesky, L. M., Goldschmidt-Clermont, P. J. and Pollard, T. D. 1990. The affinities of human platelet and Acanthamoeba profilin isoforms for polyphosphoinositides account for their relative abilities to inhibit phospholipase C. Cell Regul. 1, 937-950.PubMedGoogle Scholar
  41. Mammoto, A., Sasaki, T., Asakura, T., Hotta, I., Imamura, H., Takahashi, K., Matsuura, Y., Shirao, T. and Takai, Y. 1998. Interactions of drebrin and gephyrin with profilin. Biochem. Biophys. Res. Commun. 243, 86-89.CrossRefPubMedGoogle Scholar
  42. Markey, F., Persson, T. and Lindberg, U. 1981. Characterization of platelet extracts before and after stimulation with respect to the possible role of profilactin as microfilament precursor. Cell 23, 145-153.CrossRefPubMedGoogle Scholar
  43. Miki, H., Suetsugu, S. and Takenawa, T. 1998. WAVE, a novel WASp-family protein involved in actin reorganization induced by Rac. EMBO J. 17, 6932-6941.CrossRefPubMedGoogle Scholar
  44. Miyagi, Y., Yamashita, T., Fukaya, M., Sonoda, T., Okuno, T., Yamada, K., Watanabe, M., Nagashima, Y., Aoki, I., Okuda, K., Mishina, M. and Kawamoto, S. 2002. Delphilin: A novel PDZ and formin homology domain-containing protein that synaptically colocalizes and interacts with glutamate receptor delta 2 subunit. J. Neurosci. 22, 803-814.PubMedGoogle Scholar
  45. Moens, P. D., Bagatolli, L. A. 2007. Profilin binding to sub-micellar concentrations of phosphatidylinositol (4,5) bisphosphate and phosphatidylinositol (3,4,5) trisphosphate. Biochim. Biophys. Acta 1768, 439-449.CrossRefPubMedGoogle Scholar
  46. Molina, I. J., Sancho, J., Terhorst, C., Rosen, F. S., and Remold’Donnell, E. 1993. T cells of patients with the Wiskott-Aldrich syndrome have a restricted defect in proliferative responses. J. Immunol. 151, 4383-4390.PubMedGoogle Scholar
  47. Obermann, H., Raabe, I., Balvers, M., Brunswig, B., Schulze, W. and Kirchhoff, C. 2005. Novel testis-expressed profilin IV associated with acrosome biogenesis and spermatid elongation. Mol. Hum. Reprod. 11, 53-64.CrossRefPubMedGoogle Scholar
  48. Ostrander, D. B., Gorman, J. A. and Carman, G. M. 1995. Regulation of profilin localization in Saccharomyces cerevisiae by phosphoinositide metabolism. J. Biol. Chem. 270, 27045-27050.CrossRefPubMedGoogle Scholar
  49. Pancoast, M., Dobyns, W. and Golden, J. A. 2005. Interneuron deficits in patients with the Miller-Dieker syndrome. Acta Neuropathol. 109, 400-404.CrossRefPubMedGoogle Scholar
  50. Pantaloni, D. and Carlier, M. F. 1993. How profilin promotes actin filament assembly in the presence of thymosin beta 4. Cell 75, 1007-1014.CrossRefPubMedGoogle Scholar
  51. Parast, M. M. and Otey, C. A. 2000. Characterization of palladin, a novel protein localized to stress fibers and cell adhesions. J. Cell Biol. 150, 643-656.CrossRefPubMedGoogle Scholar
  52. Perelroizen, I., Carlier, M. F. and Pantaloni, D. 1995. Binding of divalent cation and nucleotide to G-actin in the presence of profilin. J. Biol. Chem. 270, 1501-1508.CrossRefPubMedGoogle Scholar
  53. Radauer, C. and Breiteneder, H. 2006. Pollen allergens are restricted to few protein families and show distinct patterns of species distribution. J. Allergy Clin. Immunol. 117, 141-147.CrossRefPubMedGoogle Scholar
  54. Ramesh, N., Anton, I. M., Hartwig, J. H. and Geha, R. S. 1997. WIP, a protein associated with Wiskott-Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells. Proc. Natl Acad. Sci. USA 94, 14671-14676.CrossRefPubMedGoogle Scholar
  55. Reeve, S. P., Bassetto, L., Genova, G. K., Kleyner, Y., Leyssen, M., Jackson, F. R. and Hassan, B. A. 2005. The Drosophila fragile X mental retardation protein controls actin dynamics by directly regulating profilin in the brain. Curr. Biol. 15, 1156-1163.CrossRefPubMedGoogle Scholar
  56. Reichstein, E. and Korn, E. D. 1979. Acanthamoeba profilin. A protein of low molecular weight from Acanthamoeba castellanii that inhibits actin nucleation. J. Biol. Chem. 254, 6174-6179.PubMedGoogle Scholar
  57. Reinhard, M., Giehl, K., Abel, K., Haffner, C., Jarchau, T., Hoppe, V., Jockusch, B. M. and Walter, U. 1995. The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins. EMBO J. 14, 1583-1589.PubMedGoogle Scholar
  58. dos Remedios, C. G., Chhabra, D., Kekic, M., Dedova, I. V., Tsubakihara, M., Berry, D. A. and Nosworthy, N. J. 2003. Actin binding proteins: Regulation of cytoskeletal microfilaments. Physiol. Rev. 83, 433-473.PubMedGoogle Scholar
  59. Rogaev, E. I., Sherrington, R., Rogaeva, E. A., Levesque, G., Ikeda, M., Liang, Y., Chi, H., Lin, C., Holman, K., Tsuda, T., Mar, L., Sorbi, S., Nacmias, B., Piacentini, S., Amaducci, L., Chumakov, I., Cohen, D., Lannfelt, L., Fraser, P. E., Rommens, J. M. and St George-Hyslop, P. 1995. Familial Alzheimer’s disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer’s disease type 3 gene. Nature 376, 775-778.CrossRefPubMedGoogle Scholar
  60. Rosen, F. S., Cooper, M. D. and Wedgwood, R. J. 1995. The primary immunodeficiencies. N. Engl. J. Med. 333, 431-440.CrossRefPubMedGoogle Scholar
  61. Rothkegel, M., Mayboroda, O., Rohde, M., Wucherpfennig, C., Valenta, R. and Jockusch, B. M. 1996. Plant and animal profilins are functionally equivalent and stabilize microfilaments in living animal cells. J. Cell Sci. 109, 83-90.PubMedGoogle Scholar
  62. Roy, P. and Jacobson, K. 2004. Overexpression of profilin reduces the migration of invasive breast cancer cells. Cell Motil. Cytoskeleton 57, 84-95.CrossRefGoogle Scholar
  63. Sathish, K., Padma, B., Munugalavadla, V., Bhargavi, V., Radhika, K. V., Wasia, R., Sairam, M. and Singh, S. S. 2004. Phosphorylation of profilin regulates its interaction with actin and poly (L-proline). Cell Signal. 16, 589-596.CrossRefPubMedGoogle Scholar
  64. Schutt, C. E., Myslik, J. C., Rozycki, M. D., Goonesekere, N. C. and Lindberg, U. 1993. The structure of crystalline profilin-beta-actin. Nature 365, 810-816.CrossRefPubMedGoogle Scholar
  65. Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K. et al. 1995. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer’s disease. Nature 375, 754-760.CrossRefPubMedGoogle Scholar
  66. Singh, S. S., Chauhan, A., Murakami, N. and Chauhan, V. P. 1996a. Profilin and gelsolin stimulate phosphatidylinositol 3-kinase activity. Biochemistry 35, 16544-16549.CrossRefGoogle Scholar
  67. Singh, S. S., Chauhan, A., Murakami, N., Styles, J., Elzinga, M. and Chauhan, V. P. 1996b. Phosphoinositide-dependent in vitro phosphorylation of profilin by protein kinase C. Phospholipid specificity and localization of the phosphorylation site. Recept. Signal Transduct. 6, 77-86.Google Scholar
  68. Skare, P. and Karlsson, R. 2002. Evidence for two interaction regions for phosphatidylinositol(4,5)-bisphosphate on mammalian profilin I. FEBS Lett. 522, 119-124.CrossRefPubMedGoogle Scholar
  69. Sohn, R. H., Chen, J., Koblan, K. S., Bray, P. F. and Goldschmidt-Clermont, P. J. 1995. Localization of a binding site for phosphatidylinositol 4,5-bisphosphate on human profilin. J. Biol. Chem. 270, 21114-21120.CrossRefPubMedGoogle Scholar
  70. Stewart, D. M., Tian, L. and Nelson, D. L. 1999. Mutations that cause the Wiskott-Aldrich syndrome impair the interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein. J. Immunol. 162, 5019-5024.PubMedGoogle Scholar
  71. Stocker, H., Andjelkovic, M., Oldham, S., Laffargue, M., Wymann, M. P., Hemmings, B. A. and Hafen, E. 2002. Living with lethal PIP3 levels: Viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB. Science 295, 2088-2091.CrossRefPubMedGoogle Scholar
  72. Stuven, T., Hartmann, E. and Gorlich, D. 2003. Exportin 6: A novel nuclear export receptor that is specific for profilin.actin complexes. EMBO J. 22, 5928-5940.CrossRefPubMedGoogle Scholar
  73. Suetsugu, S., Miki, H. and Takenawa, T. 1998. The essential role of profilin in the assembly of actin for microspike formation. EMBO J. 17, 6516-6526.CrossRefPubMedGoogle Scholar
  74. Tamura, M., Tanaka, H., Hirano, T., Ueta, Y., Higashi, K. and Hirano, H. 1996. Enhanced glomerular profilin gene and protein expression in experimental mesangial proliferative glomerulonephritis. Biochem. Biophys. Res. Commun. 222,683-687.CrossRefPubMedGoogle Scholar
  75. Tamura, M., Tanaka, H., Yashiro, A., Osajima, A., Okazaki, M., Kudo, H., Doi, Y., Fujimoto, S., Higashi, K., Nakashima, Y. and Hirano, H. 2000a. Expression of profilin, an actin-binding protein, in rat experimental glomerulonephritis and its upregulation by basic fibroblast growth factor in cultured rat mesangial cells. J. Am. Soc. Nephrol. 11, 423-433.Google Scholar
  76. Tamura, M., Yanagihara, N., Tanaka, H., Osajima, A., Hirano, T., Higashi, K., Yamada, K. M., Nakashima, Y. and Hirano, H. 2000b. Activation of DNA synthesis and AP-1 by profilin, an actin-binding protein, via binding to a cell surface receptor in cultured rat mesangial cells. J. Am. Soc. Nephrol. 11, 1620-1630.Google Scholar
  77. Valenta, R., Duchene, M., Breitenbach, M., Pettenburger, K., Koller, L., Rumpold, H., Scheiner, O. and Kraft, D. 1991a. A low molecular weight allergen of white birch (Betula verrucosa) is highly homologous to human profilin. Int. Arch. Allergy Appl. Immunol. 94, 368-370.CrossRefGoogle Scholar
  78. Valenta, R., Duchene, M., Ebner, C., Valent, P., Sillaber, C., Deviller, P., Ferreira, F., Tejkl, M., Edelmann, H. and Kraft, D. 1992. Profilins constitute a novel family of functional plant pan-allergens. J. Exp. Med. 175, 377-385.CrossRefPubMedGoogle Scholar
  79. Valenta, R., Duchene, M., Pettenburger, K., Sillaber, C., Valent, P., Bettelheim, P., Breitenbach, M., Rumpold, H., Kraft, D. and Scheiner, O. 1991b. Identification of profilin as a novel pollen allergen: IgE autoreactivity in sensitized individuals. Science 253, 557-560.CrossRefGoogle Scholar
  80. Vemuri, B. and Singh, S. S. 2001. Protein kinase C isozyme-specific phosphorylation of profilin. Cell Signal. 13, 433-439.CrossRefPubMedGoogle Scholar
  81. Vinson, V. K., De La Cruz, E. M., Higgs, H. N. and Pollard, T. D. 1998. Interactions of Acanthamoeba profilin with actin and nucleotides bound to actin. Biochemistry 37,10871-10880.CrossRefPubMedGoogle Scholar
  82. Vivanco, I. and Sawyers, C. L. 2002. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat. Rev. Cancer 2, 489-501.CrossRefPubMedGoogle Scholar
  83. Wang, J., Gambhir, A., McLaughlin, S. and Murray, D. 2004. A computational model for the electrostatic sequestration of PI(4,5)P2 by membrane-adsorbed basic peptides. Biophys. J. 86, 1969-1986.CrossRefPubMedGoogle Scholar
  84. Wang, X., Kibschull, M., Laue, M. M., Lichte, B., Petrasch-Parwez, E. and Kilimann, M. W. 1999. Aczonin, a 550-kD putative scaffolding protein of presynaptic active zones, shares homology regions with Rim and Bassoon and binds profilin. J. Cell Biol. 147, 151-162.CrossRefPubMedGoogle Scholar
  85. Watanabe, N., Madaule, P., Reid, T., Ishizaki, T., Watanabe, G., Kakizuka, A., Saito, Y., Nakao, K., Jockusch, B. M. and Narumiya, S. 1997. p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin. EMBO J. 16, 3044-3056.CrossRefPubMedGoogle Scholar
  86. Witke, W. 2004. The role of profilin complexes in cell motility and other cellular processes. Trends Cell Biol. 14, 461-469.CrossRefPubMedGoogle Scholar
  87. Witke, W., Podtelejnikov, A. V., Di Nardo, A., Sutherland, J. D., Gurniak, C. B., Dotti, C. and Mann, M. 1998. In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly. EMBO J. 17, 967-976.CrossRefPubMedGoogle Scholar
  88. Witke, W., Sutherland, J. D., Sharpe, A., Arai, M. and Kwiatkowski, D. J. 2001. Profilin I is essential for cell survival and cell division in early mouse development. Proc. Natl Acad. Sci. USA 98, 3832-3836.CrossRefPubMedGoogle Scholar
  89. Wittenmayer, N., Jandrig, B., Rothkegel, M., Schluter, K., Arnold, W., Haensch, W., Scherneck, S. and Jockusch, B. M. 2004. Tumor suppressor activity of profilin requires a functional actin binding site. Mol. Biol. Cell 15, 1600-1608.CrossRefPubMedGoogle Scholar
  90. Yang, C., Huang, M., DeBiasio, J., Pring, M., Joyce, M., Miki, H., Takenawa, T. and Zigmond, S. H. 2000. Profilin enhances Cdc42-induced nucleation of actin polymerization. J. Cell Biol. 150, 1001-1012.CrossRefPubMedGoogle Scholar
  91. Yayoshi-Yamamoto, S., Taniuchi, I. and Watanabe, T. 2000. FRL, a novel forminrelated protein, binds to Rac and regulates cell motility and survival of macrophages. Mol. Cell Biol. 20, 6872-6881.CrossRefPubMedGoogle Scholar
  92. Yu, F. X., Sun, H. Q., Janmey, P. A. and Yin, H. L. 1992. Identification of a polyphosphoinositide-binding sequence in an actin monomer-binding domain of gelsolin. J. Biol. Chem. 267, 14616-14621.PubMedGoogle Scholar

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© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Pierre D. J. Moens
    • 1
  1. 1.School of Biological, Biomedical and Molecular SciencesThe University of New EnglandArmidaleAustralia

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