Gelsolin and Disease

  • Leslie D. Burtnick
  • Robert C. Robinson
Part of the Protein Reviews book series (PRON, volume 8)

Gelsolin is a multifunctional regulator of actin filament formation and disassembly (reviewed in Sun et al. 1999; Kwiatkowski 1999; McGough et al. 2003; Silacci et al. 2004). It can bind to the side of an F-actin filament, sever that filament in a nonhydrolytic manner, and cap the fast growing end of one of the resultant fragments. Uncapping can be induced through the binding of specific phospholipids (see chapter by dos Remedios), for example, phosphatidylinositol 4,5-bisphosphate (PIP2), to expose the fast growing end of a prenucleated filament.


Actin Monomer Finnish Type Plasma Gelsolin Actin Regulatory Protein Familial Amyloidosis 
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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Leslie D. Burtnick
    • 1
  • Robert C. Robinson
    • 2
  1. 1.Chemistry Department and Centre for Blood Research, Life Sciences InstituteUniversity of British ColumbiaVancouverCanada
  2. 2.Institute of Molecular and Cell Biology ProteosSingapore

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