Intracellular Pathogens and the Actin Cytoskeleton
Intracellular pathogens co-opt cellular machinery in many ways. It has long been recognized that the life cycle of most viruses depends on host cell DNA replication enzymes. More recently, intracellular bacteria as well as viruses have been discovered to disrupt and redirect the host cell cytoskeleton to assist their survival and growth. Understanding pathogen-cytoskeleton interactions will provide fresh insights into targets for drug therapies or for design of immunogens for preventive vaccine development.
KeywordsActin Filament Actin Cytoskeleton Vaccinia Virus Actin Polymerization Intracellular Pathogen
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