Phosphatidylinositol(4,5) bisphosphate (PI(4,5)P2 or more simply, PIP2 is only a minor component of the cell membrane lipids but it is the most abundant of the bisphorylated phosphoinositides. PIP2 is a key ligand in regulating the activity of a number of actin-binding proteins that regulate the assembly of actin microfilaments (Logan and Mandato 2006; Yin and Janmey 2003). Because of its central role, abnormal accumulation of PIP2 in the cell might be expected to produce defects in the assembly of cytoplasmic actin microfilaments. Similarly, a substantial reduction in cellular PIP2 is also not likely to be tolerated. Thus, mutations in enzymes that control cellular PIP2 content may be responsible, either directly or indirectly, for a number of human diseases/disorders.
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dos Remedios, C.G., Nosworthy, N.J. (2008). The Role of PIP2 in Actin, Actin-Binding Proteins and Disease. In: dos Remedios, C.G., Chhabra, D. (eds) Actin-Binding Proteins and Disease. Protein Reviews, vol 8. Springer, New York, NY. https://doi.org/10.1007/978-0-387-71749-4_12
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