Actin and Actin-Binding Proteins in Cancer Progression and Metastasis

  • Marleen Van Troys
  • Joël Vandekerckhove
  • Christophe Ampe
Part of the Protein Reviews book series (PRON, volume 8)

With over 10 million cases and over 5.7 million deaths a year (GLOBOCAN data 2002; Ferlay et al. 2004), cancer presents a major health problem worldwide. Dealing with cancer, both from a clinical and from a fundamental scientific view, is complicated by the extensive diversity within this disease. Based on their origin, more than 100 different human cancer types have been described and, within one organ, distinct subtypes can occur. In addition, tumors may progress to a malignant state that manifests itself mainly when tumor cells spread out from the primary lesion (or neoplasm) and metastasize, i.e., colonize distant sites of the patient’s body. Metastatic cancer, accounts for 90% of cancer-related lethality (Sporn 1996) and hence forms the primary determining factor in patient outcome. Therefore a detailed molecular understanding of tumor cell spread is required to render treatment of cancer more specific and efficient.


Prostate Cancer Actin Filament Actin Cytoskeleton Anaplastic Lymphoma Kinase Anaplastic Large Cell Lymphoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Marleen Van Troys
    • 1
  • Joël Vandekerckhove
    • 1
  • Christophe Ampe
    • 1
  1. 1.Department of Biochemistry, Faculty of Medicine and Health SciencesGhent University and Medical Protein Research, Flanders Interuniversity Institute for Biotechnology (VIB)GentBelgium

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