Metastatic and Secondary Tumors

Part of the Essentials in Cytopathology book series (EICP, volume 4)


Metastatic and secondary tumors are uncommon in the breast (0.5%–2%) compared with primary neoplasms, but an accurate diagnosis on FNA is imperative for a definitive and rapid diagnosis, preceding the often nonsurgical treatment of these cases. The most common of these include malignant melanoma, non-Hodgkin lymphoma, and carcinomas of the lung, urogenital tract, and gynecologic tract. However, almost every known tumor has been seen metastatic to the breast and can create real diagnostic problems not only for the treating physicians and radiologists but also for pathologists when these lesions are aspirated. Radiologically (mammographically or on ultrasound), these lesions appear as single, round, discrete, and often large nodule or mass usually lacking the irregularities and microcalcifications of primary breast cancer.


Invasive Lobular Carcinoma Neuroendocrine Carcinoma Primary Breast Carcinoma Hematologic Tumor Psammoma Body 
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Selected Reading

  1. Akcay MN: Metastatic disease in the breast. Breast 2002, 11:526–528.PubMedCrossRefGoogle Scholar
  2. Cangiarella J, Symmans WF, Cohen JM, Goldenberg A, Shapiro RL, Waisman J: Malignant melanoma metastatic to the breast: a report of seven cases diagnosed by fine-needle aspiration cytology. Cancer 1998, 84:160–162.PubMedCrossRefGoogle Scholar
  3. Cangiarella J, Waisman J, Cohen JM, Chhieng D, Symmans WF, Goldenberg A: Plasmacytoma of the breast. A report of two cases diagnosed by aspiration biopsy. Acta Cytol 2000, 44:91–94.PubMedGoogle Scholar
  4. David O, Gattuso P, Razan W, Moroz K, Dhurandhar N: Unusual cases of metastases to the breast. A report of 17 cases diagnosed by fine needle aspiration. Acta Cytol 2002, 46:377–385.PubMedGoogle Scholar
  5. Domanski HA: Metastases to the breast from extramammary neoplasms. A report of six cases with diagnosis by fine needle aspiration cytology. Acta Cytol 1996, 40:1293–1300.PubMedGoogle Scholar
  6. Ewing CA, Miller MJ, Chhieng D, Lin O: Nonepithelial malignancies mimicking primary carcinoma of the breast. Diagn Cytopa-thol 2004, 31:352–357.CrossRefGoogle Scholar
  7. Filie AC, Simsir A, Fetsch P, Abati A: Melanoma metastatic to the breast: utility of fine needle aspiration and immunohistochemistry. Acta Cytol 2002, 46:13–18.PubMedGoogle Scholar
  8. Levine PH, Zamuco R, Yee HT: Role of fine-needle aspiration cytology in breast lymphoma. Diagn Cytopathol 2004, 30:332–340.PubMedCrossRefGoogle Scholar
  9. Singh NG, Kapila K, Dawar R, Verma K: Fine needle aspiration cytology diagnosis of lymphoproliferative disease of the breast. Acta Cytol 2003, 47:739–743.PubMedGoogle Scholar
  10. Sneige N, Zachariah S, Fanning TV, Dekmezian RH, Ordonez NG: Fine-needle aspiration cytology of metastatic neoplasms in the breast. Am J Clin Pathol 1989, 92:27–35.PubMedGoogle Scholar

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© Springer Science+Business Media, LLC 2007

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