Multifunctional Neuroprotective Drugs for the Treatment of Alzheimer's Disease

  • Cornelis J. Van der Schyf
  • Werner J. Geldenhuys
  • Moussa B. H. Youdim

The concept of targeting multiple disease etiologies that lead to cognitive impairment in the neurodegenerative disorder Alzheimer’s disease (AD) is challenging the widely held assumption that “ silver bullet” agents are superior to “ dirty drugs” in drug therapy. Accumulating evidence in the literature suggests that a drug with two or more mechanisms of action targeted at multiple etiologies of the same disease may offer more therapeutic benefit in certain disorders than a drug that targets one disease etiology only. In addition, such multiple mechanism/multifunctional drugs may exhibit a more favorable side effect profile than a polypharmaceutical combination of several drugs that individually target the same disease etiologies than those identified for a single multifunctional drug. In this chapter, we offer a synopsis of therapeutic strategies and novel investigative drugs, developed in our own and other laboratories, which modulate multiple disease targets associated with AD and cognitive impairment disorders.


NMDA Receptor Dementia With Lewy Body Nicotinic Acetylcholine Receptor NMDA Receptor Antagonist Adenosine Receptor Antagonist 
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© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Cornelis J. Van der Schyf
    • 1
  • Werner J. Geldenhuys
    • 1
  • Moussa B. H. Youdim
    • 2
  1. 1.Department of Pharmaceutical SciencesNortheastern Ohio Universities College of PharmacyRootstownUSA
  2. 2.Technion-Rappaport Family-Faculty of Medicine Eve TopfU.S. National Parkinson Foundation Centers of Excellence for Neurodegenerative DiseasesIsrael

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