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Neuroinflammation, Alzheimer Disease, and Other Aging Disorders

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Pharmacological Mechanisms in Alzheimer's Therapeutics

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Neuroinflammation is defined as a localized response to CNS tissue damage. It is characterized by activated microglia attacking the injury source, activated astrocytes limiting the area of involvement, and resident brain cells, including neurons, generating multiple inflammatory mediators. It may expand to involve invasion by leukocytes and serum factors. Studies on Alzheimer disease (AD) over the past two decades have provided much new information about chronic neuroinflammation. This information may have relevance not only to many neurological disorders but also, by extension and with some modification, to such important diseases as atherosclerosis, heart disease, and macular degeneration.

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  1. Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, BC, Canada

    Edith G. McGeer & Patrick L. McGeer

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McGeer, E.G., McGeer, P.L. (2007). Neuroinflammation, Alzheimer Disease, and Other Aging Disorders. In: Pharmacological Mechanisms in Alzheimer's Therapeutics. Springer, New York, NY. https://doi.org/10.1007/978-0-387-71522-3_10

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