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Lymphatic Vascular System and Lymphangiogenesis

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Book cover Angiogenesis

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The lymphatic system plays an important role in the maintenance of tissue fluid homeostasis, in the afferent phase of the immune response, and in metastatic cancer spread. However, the scientific exploration of the lymphatic system has lagged behind that of the blood vascular system, largely due to the absence of specific markers for lymphatic endothelium and to the paucity of knowledge about the molecular regulators of its development and function. The recent identification of genes that specifically control lymphatic development and the growth of lymphatic vessels (lymphangiogenesis), as well as the discovery of novel lymphatic endothelium-specific markers, have now provided important insights into the molecular mechanisms that control lymphatic growth and function. Studies of genetic mouse models have led to a new molecular model for embryonic lymphatic vascular development, and they have identified molecular pathways whose mutational inactivation leads to human diseases associated with lymphedema. Moreover, recent evidence indicates that malignant tumors can directly promote lymphangiogenesis and lymphatic metastasis, and that lymphangiogenesis also has a major role in chronic inflammation.

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Authors and Affiliations

  1. Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland

    Leah N. Cueni & Michael Detmar

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  1. Leah N. Cueni
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  2. Michael Detmar
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Editors and Affiliations

  1. Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA

    William D. Figg

  2. Department of Surgery Harvard Medical School and Vascular Biology Program, Children's Hospital Boston, Boston, MA, USA

    Judah Folkman

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Cueni, L.N., Detmar, M. (2008). Lymphatic Vascular System and Lymphangiogenesis. In: Figg, W.D., Folkman, J. (eds) Angiogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-71518-6_43

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  • DOI: https://doi.org/10.1007/978-0-387-71518-6_43

  • Publisher Name: Springer, Boston, MA

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