Advertisement

Innate Immunity in Type C Hepatitis

  • Tetsuo Takehara
  • Norio Hayashi

Keywords

Hepatoma Cell Line NKG2D Expression NKG2A Expression Decrease NKG2D Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ahmad, A., Alvarez, F. (2004). Role of NK and NKT cells in the immunopathogenesis of HCV-induced hepatitis. Journal of Leukocyte Biology, 76: 743–759.PubMedCrossRefGoogle Scholar
  2. Akira, S., Uematsu, S., Takeuchi, O. (2006). Pathogen recognition and innate immunity. Cell, 124: 783–801.PubMedCrossRefGoogle Scholar
  3. Armeanu, S., Bitzer, M., Lauer, U.M., Venturelli, S., Pathil, A., Krusch, M., Kaiser, S., Jobst, J., Smirnow, I., Wagner, A., Steinle, A., Salih, H.R. (2005). Natural killer cell-mediated lysis of hepatoma cells via specific induction of NKG2D ligands by the histone deacetylase inhibitor sodium valproate. Cancer Research, 65: 6321–6329.PubMedCrossRefGoogle Scholar
  4. Avila, M.A., Berasain, C., Sangro, B., Prieto, J. (2005). New therapies for hepatocellular carcinoma. Oncogene, 25: 3866–3884.CrossRefGoogle Scholar
  5. Bahram, S., Bresnahan, M., Geraghty, D.E., Spies, T. (1994). A second lineage of mammalian major histocompatibility complex class I genes. Proceedings of the National Academy of Sciences of the United States of America, 91: 6259–6263.Google Scholar
  6. Bauer, S., Groh, V., Wu, J., Steinle, A., Phillips, J.H., Lanier, L.L., Spies, T. (1999). Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science, 285: 727–729.PubMedCrossRefGoogle Scholar
  7. Biron, C.A. (2001). Interferons alpha and beta as immune regulators—a new look. Immunity, 6: 661–664.CrossRefGoogle Scholar
  8. Butterfield, L.H. (2004). Immunotherapeutic strategies for hepatocellular carcinoma. Gastroenterology, 127: S232–S241.PubMedCrossRefGoogle Scholar
  9. Choo, Q.L., Kuo, G., Weiner, A.J., Overby, L.R., Bradley, D.W., Houghton, M. (1989). Isolation of cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science, 244: 359–362.PubMedCrossRefGoogle Scholar
  10. Dranoff, G. (2004). Cytokines in cancer pathogenesis and cancer therapy. Nature Reviews Cancer, 4: 11–22.PubMedCrossRefGoogle Scholar
  11. Gasser, S., Orrulic, S., Brown, E.J., Raulet, D.H. (2005). The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature, 436: 1186–1190.PubMedCrossRefGoogle Scholar
  12. Gerosa, F., Baldani-Guerra, B., Nisii, C., Marchesini, V., Carra, G., Trinchieri, G. (2002). Reciprocal activating interaction between natural killer cells and dendritic cells. Journal of Experimental Medicine, 195: 327–333.PubMedCrossRefGoogle Scholar
  13. Golden-Mason, L., Rosen, H.R. (2006). Natural killer cells: primary target for hepatitis C virus immune evasion strategies? Liver Transplantation, 12: 363–372.PubMedCrossRefGoogle Scholar
  14. Groh, V., Wu, J., Yee, C., Spies, T. (2002). Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. Nature, 419: 734–738.PubMedCrossRefGoogle Scholar
  15. Hayashi, N., Takehara, T. (2006). Anti-viral therapy for chronic hepatitis C: past, present, and future. Journal of Gastroenterology, 41: 17–27.PubMedCrossRefGoogle Scholar
  16. Jinushi, M., Takehara, T., Kanto, T., Tatsumi, T., Groh, V., Spies, T., Miyagi, T., Suzuki, T., Sasaki, Y., Hayashi, N. (2003a). Critical role of MHC class I-related chain A and B expression on interferon α-stimulated dendritic cells in NK cell activation: Impairment in chronic hepatitis C virus infection. Journal of Immunology, 170: 1249–1256.Google Scholar
  17. Jinushi, M., Takehara, T., Tatsumi, T., Kanto, T., Groh, V., Spies, T., Suzuki, T., Miyagi, T., Hayashi, N. (2003b). Autocrine/paracrine IL-15 that is required for type I IFN-mediated dendritic cell expression of MHC class I-related chain A and B is impaired in hepatitis C virus infection. Journal of Immunology, 171: 5423–5429.Google Scholar
  18. Jinushi, M., Takehara, T., Tatsumi, T., Kanto, T., Groh, V., Spies, T., Kimura, R., Miyagi, T., Mochizuki, K., Sasaki, Y., Hayashi, N. (2003c). Expression and role of MICA and MICB in human hepatocellular carcinomas and their regulation by retinoic acid. International Journal of Cancer, 104: 354–361.CrossRefGoogle Scholar
  19. Jinushi, M., Takehara, T., Tatsumi, T., Kanto, T., Miyagi, T., Suzuki, T., Kanazawa, Y., Hiramatsu, N., Hayashi, N. (2004). Negative regulation of NK cell activities by inhibitory receptor CD94/NKG2A leads to altered NK cell-induced modulation of dendritic cell functions in chronic hepatitis C virus infection. Journal of Immunology, 173: 6072–6081.Google Scholar
  20. Jinushi, M., Takehara, T., Tatsumi, T., Hiramatsu, N., Sakamori, R., Yamaguchi, S., Hayashi, N. (2005). Impairment of natural killer cell and dendritic cell functions by the soluble form of MHC class I-related chain A in advanced human hepatocellular carcinomas. Journal of Hepatology, 43: 1013–1020.PubMedCrossRefGoogle Scholar
  21. Jinushi, M., Takehara, T., Tatsumi, T., Yamaguchi, S., Sakamori, R., Hiramatsu, N., Kanto, T., Ohkawa, K., Hayashi, N. (2006). Natural killer cell and hepatic cell interaction via NKG2A leads to dendritic cell-mediated induction of CD4+ CD25+ T cells with PD-1-dependent regulatory activities. Immunology, in press.Google Scholar
  22. Kaisho, T., Akira, S. (2003). Regulation of dendritic cell function through Toll-like receptors. Current Molecular Medicine, 4: 373–385.CrossRefGoogle Scholar
  23. Karre, K., Ljunggren, H.G., Piontek, G., Keissling, R. (1986). Selective rejection of H-2 deficient lymphoma variants suggest alternative immune defense strategy. Nature, 319: 675–678.PubMedCrossRefGoogle Scholar
  24. Kato, T., Miyamoto, M., Date, T., Yasui, K., Taya, C., Yonekawa, H., Ohue, C., Yagi, S., Seki, E., Hirano, T., Fujimoto, J., Shirai, T., Wakita, T. (2003). Repeated hepatocyte injury promotes hepatic tumorigenesis in hepatitis C virus transgenic mice. Cancer Science, 94: 679–685.PubMedCrossRefGoogle Scholar
  25. Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J.M., Hoffmann, J.A. (1996). The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell, 86: 973–983.PubMedCrossRefGoogle Scholar
  26. Ljunggren, H.G., Karre, K. (1990). In search on the “missing self”: MHC molecules and NK cell recognition. Immunology Today, 11: 7–10.CrossRefGoogle Scholar
  27. Miyagi, T., Tatsumi, T., Takehara, T., Kanto, T., Kuzushita, N., Sugimoto, Y., Jinushi, M., Kasahara, A., Sasaki, Y., Hori, M., Hayashi, N. (2003). Impaired expression of proteasome subunits and human leukocyte antigens class I in human colon cancer cells. Journal of Gastroenterology and Hepatology, 18: 32–40.PubMedCrossRefGoogle Scholar
  28. Moriya, K., Fujie, H., Shintani, Y., Yotsuyanagi, H., Tsutsumi, T., Ishibashi, K., Matsuura, Y., Kimura, S., Miyamura, T., Koike, K. (1998). The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nature Medicine, 4: 1065–1067.PubMedCrossRefGoogle Scholar
  29. Okuda, M., Li, K., Beard, M.R., Showalter, L.A., Scholle, F., Lemon, S.M., Weinman, S.A. (2002). Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology, 122: 366–375.PubMedCrossRefGoogle Scholar
  30. Otsuka, M., Kato, N., Taniguchi, H., Yoshida, H., Goto, T., Shiratori, Y., Omata, M. (2002). Hepatitis C virus core protein inhibits apoptosis via enhanced Bcl-xL expression. Virology, 296: 84–93.PubMedCrossRefGoogle Scholar
  31. Palmer, D.H., Hussain, S.A., Johnson, P.J. (2005). Gene- and immunotherapy for hepatocellular carcinoma. Expert Opinion on Biological Therapy, 5: 507–523.PubMedCrossRefGoogle Scholar
  32. Prince, A.M., Brotman, B., Grady, G.F., Kuhns, W.J., Hazzi, C., Levine, R.W., Millian, S.J. (1974). Long-incubation post-transfusion hepatitis without serological evidence of exposure to hepatitis-B virus. Lancet, 7875: 241–246.CrossRefGoogle Scholar
  33. Raulet, D.H. (2003). Roles of the NKG2D immunoreceptor and its ligands. Nature Reviews Immunology, 10: 781–790.CrossRefGoogle Scholar
  34. Ravetch, J.V., Lanier, L.L. (2000). Immune inhibitory receptors. Science, 290: 84–89.PubMedCrossRefGoogle Scholar
  35. Salih, H.R., Rammensee, H.G., Steinle, A. (2002). Downregulation of MICA on human tumors by proteolytic shedding. Journal of Immunology, 169: 4098–4102.Google Scholar
  36. Skov, S., Pedersen, M.T., Andresen, L., Straten, P.T., Woetmann, A., Odum, N. (2005). Cancer cell become susceptible to natural killer cell killing after exposure to histone deacetylase inhibitors due to glycogen synthase kinase-3-dependent expression of MHC class I-related chain A and B. Cancer Research, 65: 11136–11145.PubMedCrossRefGoogle Scholar
  37. Smyth, M.J., Hayakawa, Y., Takeda, K., Yagita, H. (2002). New aspects of natural-killer-cell surveillance and therapy of cancer. Nature Reviews Cancer, 2: 850–861.PubMedCrossRefGoogle Scholar
  38. Takehara, T., Hayashi, N., Katayama, K., Ueda, K., Towata, T., Kasahara, A., Fusamoto, H., Kamada, T. (1992). Enhanced expression of HLA class I by inhibited replication of hepatitis B virus. Journal of Hepatology, 14: 232–236.PubMedCrossRefGoogle Scholar
  39. Takehara, T., Liu, X., Fujimoto, J., Friedman, S.L., Takahashi, H. (2001). Expression and role of Bcl-xL in human hepatocellular carcinomas. Hepatology, 34: 55–61.PubMedCrossRefGoogle Scholar
  40. Takehara, T., Takahashi, H. (2003). Suppression of Bcl-xL deamidation in human hepatocellular carcinomas. Cancer Research, 63: 3054–3057.PubMedGoogle Scholar
  41. Takehara, T., Hayashi, N. (2005). Natural killer cells in hepatitis C virus infection: from innate immunity to adaptive immunity. Clinical Gastroenterology and Hepatology, 3: S78–S81.PubMedCrossRefGoogle Scholar
  42. Trinchieri, (1989). Biology of natural killer cells. Advances in Immunology, 47: 187–376.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Tetsuo Takehara
  • Norio Hayashi

There are no affiliations available

Personalised recommendations