Cardiac Resynchronization for Heart Failure: Do We Need More Trials?

  • Sunil T. Mathew
  • Christina M. Murray
  • Dwight W. Reynolds


Cardiac Resynchronization Therapy Biventricular Pace Left Ventricular Lead Right Bundle Branch Block Right Bundle Branch Block 
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  1. 1.
    Hochleitner M, Hortnagl H, Choi-Keung N, et al. Usefulness of physiologic dual-chambered pacing in drug-resistant idiopathic dilated cardiomyopathy. Am J Cardiol 1990;66:198–202.PubMedCrossRefGoogle Scholar
  2. 2.
    Gregoratos G, Abrams J, Epstein AE, et al. ACC/AHA/NASPE 2002 guideline update for implantation of cardiac pacemakers and antiarrhythmia devices: summary article. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/NASPE Committee to update the 1998 pacemaker guidelines). Circulation 2002;106:2145–61.PubMedCrossRefGoogle Scholar
  3. 3.
    Hunt SA, Abraham WT, Chin SA, et al. ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): Developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: Endorsed by the Heart Rhythm Society. Circulation 2005;112:154–235.CrossRefGoogle Scholar
  4. 4.
    Cleland JG, Daubert JC, Erdmann E, et al. Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators. The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med 2005;352(15):1539–49.PubMedCrossRefGoogle Scholar
  5. 5.
    Stellbrink C, Breithardt OA, Franke A, et al. PATH-CHF (PAcing THerapies in Congestive Heart Failure) Investigators; CPI Guidant Congestive Heart Failure Research Group. Impact of cardiac resynchronization therapy using hemodynamically optimized pacing on left ventricular remodeling in patients with congestive heart failure and ventricular conduction disturbances. J Am Coll Cardiol 2001;38(7):1957–65.PubMedCrossRefGoogle Scholar
  6. 6.
    Abraham WT, Fisher WG, Smith AL, et al. Cardiac resynchronization in chronic heart failure. N Engl J Med 2002;346:1845–53.PubMedCrossRefGoogle Scholar
  7. 7.
    Young JB, Abraham WT, Smith AL, et al. Multicenter InSync ICD Randomized Clinical Evaluation (MIRACLE ICD) Trial Investigators. Combined cardiac resynchronization and implantable cardioversion defibrillation in advanced chronic heart failure: The MIRACLE ICD trial. JAMA 2003;289:2685–94.PubMedCrossRefGoogle Scholar
  8. 8.
    Cazeau S, Leclercq C, Lavergne T, et al. Effects of multisite biventricular pacing in patients with heart failure and intraventricular conduction delay. N Engl J Med 2001;344:873–80.PubMedCrossRefGoogle Scholar
  9. 9.
    U.S. FDA. Summary of Safety and Effectiveness: Guidant CONTAK CD CRT-D System. U.S. Food and Drug Administration. Available at: http://www.fda. gov/cdrh/pdf/p010012.html.Google Scholar
  10. 10.
    Bristow MR, Saxon LA, Boehmer J, et al. Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N Engl J Med 2004;350:2140–50.PubMedCrossRefGoogle Scholar
  11. 11.
    Foster A, Gold M, McGlaughlin J. Acute hemodynamic effects of atrio-biventricular pacing in humans. Ann Thorac Surg 1995;59:294–300.PubMedCrossRefGoogle Scholar
  12. 12.
    Cazeau S, Ritter P, Lazarus A, et al. Multisite pacing for end-stage heart failure: early experience. PACE 1996;19(Pt II):1742–57.Google Scholar
  13. 13.
    Leclercq C, Cazeau S, Breton H, et al. Acute hemodynamic effects of biventricular DDD pacing in patients with end-stage heart failure. J Am Coll Cardiol 1998;32:1825–31.PubMedCrossRefGoogle Scholar
  14. 14.
    Hamdan M, Zagrodsky J, Joglar J, et al. Biventricular pacing decreases sympathetic activity compared with right ventricular pacing in patients with depressed ejection fraction. Circulation 2000;102:1027–32.PubMedGoogle Scholar
  15. 15.
    Kass D, Chen-Hyan C, Curry C, et al. Improved left ventricular mechanics from acute VDD pacing in patients with dilated cardiomyopathy and ventricular conduction delay. Circulation 1999;99:1567–73.PubMedGoogle Scholar
  16. 16.
    Innes D, Keitch J, Fletcher P, et al. VDD pacing at short atrioventricular intervals does not improve cardiac output in patients with dilated heart failure [abstract]. PACE 1994;17:959.PubMedGoogle Scholar
  17. 17.
    Linde C, Gadler F, Edner M, et al. Results of atrioventricular synchronous pacing with optimized delay in patients with severe congestive heart failure [abstract]. Am J Cardiol 1995;75:919.PubMedCrossRefGoogle Scholar
  18. 18.
    Brecker S, Gibson D. What is the role of pacing in dilated cardiomyopathy? Eur Heart J 1996;17:819.PubMedGoogle Scholar
  19. 19.
    Leclercq C, Cazeau S, Ritter P, et al. A pilot experience with permanent biventricular pacing to treat advanced heart failure. Am Heart J 2000;140(6):862–70.PubMedCrossRefGoogle Scholar
  20. 20.
    Gras D, Leclercq C, Tang AS, et al. Cardiac resynchronization therapy in advanced heart failure the multicenter InSync clinical study. Eur J Heart Fail 2002;4(3): 311–20.PubMedCrossRefGoogle Scholar
  21. 21.
    Kuhlkamp V, InSync 7272 ICD World Wide Investigators. Initial experience with an implantable cardioverter-defibrillator incorporating cardiac resynchronization therapy. J Am Coll Cardiol 2002;39(5):790–7.PubMedCrossRefGoogle Scholar
  22. 22.
    Flather MD, Yusuf S, Kober L, et al. Long-term ACE-inhibitor therapy in patients with heart failure or left-ventricular dysfunction: A systematic overview of data from individual patients. ACE-Inhibitor Myocardial Infarction Collaborative Group. Lancet. 2000;355:1575–81.PubMedCrossRefGoogle Scholar
  23. 23.
    Brophy JM, Joseph L, Rouleau JL. Beta-blockers in congestive heart failure. A Bayesian meta-analysis. Ann Intern Med 2001;134:550–60.PubMedGoogle Scholar
  24. 24.
    Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999;341:709–17.PubMedCrossRefGoogle Scholar
  25. 25.
    Pitt B, Remme W, Zannad F, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 2003;348:1309–21.PubMedCrossRefGoogle Scholar
  26. 26.
    Rector TS, Cohn JN. Assessment of patient outcome with the MinnesotaLiving with Heart Failure questionnaire: Reliability and validity during a randomized, double-blind, placebo-controlled trial of pimobendan. Pimobendan Multicenter Research Group. Am Heart J 1992;124:1017–25.PubMedCrossRefGoogle Scholar
  27. 27.
    Rector TS, Kubo SH, Cohn JN. Validity of the Minnesota Living with Heart Failure questionnaire as a measure of therapeutic response to enalapril or placebo. Am J Cardiol 1993;71:1106–7.PubMedCrossRefGoogle Scholar
  28. 28.
    Rector TS, Johnson G, Dunkman WB, et al. Evaluation by patients with heart failure of the effects of enalapril compared with hydralazine plus isosorbide dinitrate on quality of life. V-HeFT II. The V-HeFT VA Cooperative Studies Group. Circulation 1993;87:VI71–7.PubMedGoogle Scholar
  29. 29.
    Cohn JN, Tognoni G. A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. N Engl J Med 2001;345:1667–75.PubMedCrossRefGoogle Scholar
  30. 30.
    Hjalmarson A, Goldstein S, Fagerberg B, et al. Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure: the Metoprolol CR/XL Randomized Intervention Trial in congestive heart failure (MERIT-HF). MERIT-HF Study Group. JAMA 2000;283:1295–302.PubMedCrossRefGoogle Scholar
  31. 31.
    Bradley DJ, Bradley EA, Baughman KL, et al. Cardiac resynchronization and death from progressive heart failure: a meta-analysis of randomized controlled trials. JAMA 2003;289(6):730–40.PubMedCrossRefGoogle Scholar
  32. 32.
    McAlister FA, Ezekowitz JA, Wiebe N, et al. Systematic review: Cardiac resynchronization in patients with symptomatic heart failure. Ann Intern Med 2004;141:381–90.PubMedGoogle Scholar
  33. 33.
    Davis DR, Krahn AD, Tang ASL, et al. Long-term outcome of cardiac resynchronization therapy in patients with severe congestive heart failure. Can J Cardiol 2005;21:413–7.PubMedGoogle Scholar
  34. 34.
    Bax JJ, Ansalone G, Breithardt OA, et al. Echocardiographic evaluation of cardiac resynchronization therapy: Ready for routine clinical use? A critical appraisal. J Am Coll Cardiol 2004;44:1–9.PubMedCrossRefGoogle Scholar
  35. 35.
    Yu CM, Fung WH, Lin H, et al. Predictors of left ventricular reverse remodeling after cardiac resynchronization therapy for heart failure secondary to idiopathic dilated or ischemic cardiomyopathy. Am J Cardiol 2003;91:684–88.PubMedCrossRefGoogle Scholar
  36. 36.
    Kim WY, Sogaard P, Mortensen PT, et al. Three dimensional echocardiography documents haemodynamic improvement by biventricular pacing in patients with severe heart failure. Heart 2001;85:514–20.PubMedCrossRefGoogle Scholar
  37. 37.
    Pitzalis MV, Iacoviello M, Romito R, et al. Cardiac resynchronization therapy tailored by echocardiographic evaluation of ventricular asynchrony. J Am Coll Cardiol 2002;40:1615–22.PubMedCrossRefGoogle Scholar
  38. 38.
    Reuter S, Garrigue S, Barold SS, et al. Comparison of characteristics in responders versus nonresponders with biventricular pacing for drug-resistant congestive heart failure. Am J Cardiol 2002;89:346–50.PubMedCrossRefGoogle Scholar
  39. 39.
    Sogaard P, Egeblad H, Kim WY, et al. Tissue Doppler imaging predicts improved systolic performance and reversed left ventricular remodeling during long-term cardiac resynchronization therapy. J Am Coll Cardiol 2002;40:723–30.PubMedCrossRefGoogle Scholar
  40. 40.
    Rossillo A, Verma A, Saad EB, et al. Impact of coronary sinus lead position on biventricular pacing: Mortality and echocardiographic evaluation during long-term follow-up. J Cardiovasc Electrophysiol 2004;15:1120–25.PubMedCrossRefGoogle Scholar
  41. 41.
    Auricchio A, Fantoni C. Cardiac resynchronization therapy in heart failure. Ital Heart J 2005;6(3):256–60.PubMedGoogle Scholar
  42. 42.
    Bardy GH, Lee KL, Mark DB, et al, for the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) Investigators. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med 2005;352:225–37.PubMedCrossRefGoogle Scholar
  43. 43.
    Ellenbogen KA, Hellkamp AS, Wilkoff BL, et al. Complications arising after implantation of DDD pacemakers: the MOST experience. Am J Cardiol 2003;92:740–1.PubMedCrossRefGoogle Scholar
  44. 44.
    Ezekowitz JA, Armstrong PW, McAlister FA. Implantable cardioverter defibrillators in primary and secondary prevention: A systematic review of randomized, controlled trials. Ann Intern Med 2003;138:445–52.PubMedGoogle Scholar
  45. 45.
    Higgins SL, Hummel JD, Niazi IK, et al. Cardiac resynchronization therapy for the treatment of heart failure in patients with intraventricular conduction delay and malignant ventricular tachyarrhythmias. J Am Coll Cardiol 2003;42: 1454–59.PubMedCrossRefGoogle Scholar
  46. 46.
    Auricchio A, Stellbrink C, Sack S, et al. Long-term clinical effect of hemodynamically optimized cardiac resynchronization therapy in patients with heart failure and ventricular conduction delay. J Am Coll Cardiol 2002;39:2026–33.PubMedCrossRefGoogle Scholar
  47. 47.
    Garrigue S, Bordachar P, Reuter S, et al. Comparison of permanent left ventricular and biventricular pacing in patients with heart failure and chronic atrial fibrillation: prospective haemodynamic study. Heart 2002;87:529–34.PubMedCrossRefGoogle Scholar
  48. 48.
    Leclercq C, Cazeau S, Lellouche D, et al. Upgrading from right ventricular pacing to biventricular pacing in previously paced patients with advanced heart failure: A randomized controlled study [the RD-CHF Trial] [abstract]. Presented at the European Society of Cardiology Congress, Vienna, Austria, 30 August–3 September 2003.Google Scholar
  49. 49.
    Leclercq C, Walker S, Linde C, et al. Comparative effects of permanent biventricular and right-univentricular pacing in heart failure patients with chronic atrial fibrillation. Eur Heart J 2002;23:1780–7.PubMedCrossRefGoogle Scholar
  50. 50.
    Turner MS, Bleasdale RA, Vinereanu D, et al. Electrical and mechanical components of dyssynchrony in heart failure patients with normal QRS duration and left bundle-branch block: Impact of left and biventricular pacing. Circulation 2004;109:2544–9.PubMedCrossRefGoogle Scholar
  51. 51.
    Leon A, Greenberg J, Kanaru N, et al. Cardiac resynchronization in patients with congestive heart failure and chronic atrial fibrillation. J Am Coll Cardiol 2002;39(8):1258–63.PubMedCrossRefGoogle Scholar
  52. 52.
    Doshi R, Daoud E, Fellows C, et al. Left ventricular-based cardiac stimulation post AV nodal ablation evaluation (The PAVE Study). J Cardiovasc Electrophysiol 2005;16(11):1160–5.PubMedCrossRefGoogle Scholar
  53. 53.
    Hoppe U, Cesares J, Eiskjaer H, et al. Effect of cardiac resynchronization on the incidence of atrial fibrillation in patients with severe heart failure. Circulation 2006;114(1):18–25.PubMedCrossRefGoogle Scholar
  54. 54.
    Padeletti L, Musilli N, Porciani M, et al. Atrial fibrillation and cardiac resynchronization therapy: the MASCOT Study. Europace 2004;5(Suppl 1):S49–54.PubMedCrossRefGoogle Scholar
  55. 55.
    Aranda J, Conti J, Johnson J, et al. Cardiac resynchronization therapy in patients with heart failure and conduction abnormalities other than left bundle branch block: analysis of the Multicenter InSync Randomized Clinical Evaluation. Clin Cardiol 2004;27(12):678–82.PubMedCrossRefGoogle Scholar
  56. 56.
    Egoavil C, Ho R, Greenspoon A, et al. Cardiac resynchronization therapy in patients with right bundle branch block: Analysis of pooled data from the MIRACLE and CONTAK CD Trials, Comment. Heart Rhythm 2005;2(6):616–8.CrossRefGoogle Scholar
  57. 57.
    Achilli A, Sassara M, Ficili S, et al. Long-term effectiveness of cardiac resynchronization therapy in patients with refractory heart failure and narrow QRS. J Am Coll Cardiol 2003;42:2117–24.PubMedCrossRefGoogle Scholar
  58. 58.
    Yu C, Lin H, Zhang Q, et al. High prevalence of left ventricular systolic and diastolic asynchrony in patients with congestive heart failure and normal QRS duration. Heart 2003;89:54–60.PubMedCrossRefGoogle Scholar
  59. 59.
    Yu C, Fung W, Lin H, et al. Predictors of left ventricular reverse remodeling after cardiac resynchronization therapy for heart failure secondary to idiopathic dilated or ischemic cardiomyopathy. Am J Cardiol 2002;91:684–8.CrossRefGoogle Scholar
  60. 60.
    Yu C, Abraham W, Bax J, Chung E, et al. PROSPECT Investigators. Predictors of response to cardiac resynchronization therapy (PROSPECT)—study design. Am Heart J 2005;149(4):600–5.PubMedCrossRefGoogle Scholar
  61. 61.
    Kedia N, Ng K, Apperson-Hansen C, et al. Usefulness of atrioventricular delay optimization using doppler assessment of mitral inflow in patients undergoing cardiac resynchronization therapy. Am J Cardiol 2006;98:780–5.PubMedCrossRefGoogle Scholar
  62. 62.
    Butter C, Auriccio A, Stellbrink C, et al. Effect of resynchronization therapy stimulation site on the systolic function of heart failure patients. Circulation 2001;104:3026–9.PubMedCrossRefGoogle Scholar
  63. 63.
    Murphy R, Sigurdsson G, Mulamalla S, et al. Tissue synchronization imaging and optimal left ventricular pacing site in cardiac resynchronization therapy. Am J Cardiol 2006;97(11)1615–21.PubMedCrossRefGoogle Scholar
  64. 64.
    Linde C, Gold M, Abraham W, et al., REVERSE Study Group. Rationale and design of a randomized controlled trial to assess the safety and efficacy of cardiac resynchronization therapy in patients with asymptomatic left ventricular dysfunction with previous symptoms or mild heart failure. Am Heart J 2006;151(2):288–94.PubMedCrossRefGoogle Scholar
  65. 65.
    Moss A, Zareba W, Hall W, et al. Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med 2002;346(12):877–83.PubMedCrossRefGoogle Scholar
  66. 66.
    DAVID Trial Investigators. Dual chamber or ventricular backup pacing in patients with an implantable defibrillator. JAMA 2002;288(24):3115–23.Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Sunil T. Mathew
  • Christina M. Murray
  • Dwight W. Reynolds

There are no affiliations available

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