Programmability of the Interventricular Interval During Cardiac Resynchronization Therapy

  • S. Serge Barold
  • Arzu Ilercil
  • Bengt Herweg


Right Ventricular Cardiac Resynchronization Therapy Biventricular Pace Velocity Time Integral Anodal Stimulation 
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  1. 1.
    Whinnett ZI, Davies JE, Willson K, et al. Haemodynamic effects of changes in AV and VV delay in cardiac resynchronization therapy show a consistent pattern: analysis of shape, magnitude and relative importance of AV and VV delay. Heart. 2006;92:1628–34.PubMedCrossRefGoogle Scholar
  2. 2.
    Whinnett ZI, Davies JE, Willson K, et al. Determination of optimal atrioventricular delay for cardiac resynchronization therapy using acute non-invasive blood pressure. Europace 2006;8:358–66.PubMedCrossRefGoogle Scholar
  3. 3.
    Burri H, Sunthorn H, Somsen A, et al. Optimizing sequential biventricular pacing using radionuclide ventriculography. Heart Rhythm 2005;2:960–5.PubMedCrossRefGoogle Scholar
  4. 4.
    St. Jude Medical. Analysis of QuickOpt™timing cycle optimization. An IEGM method to optimize AV, PV, and VV delays. Sylmar, CA: St. Jude Medical; 2006.Google Scholar
  5. 5.
    Bax JJ, Abraham T, Barold SS, et al. Cardiac resynchronization therapy: Part 2–issues during and after device implantation and unresolved questions. J Am Coll Cardiol 2005;46:2168–82.PubMedCrossRefGoogle Scholar
  6. 6.
    Jansen AH, Bracke FA, van Dantzig JM, et al. Correlation of echo-Doppler optimization of atrioventricular delay in cardiac resynchronization therapy with invasive hemodynamics in patients with heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 2006;97:552–7.PubMedCrossRefGoogle Scholar
  7. 7.
    Bax JJ, Ansalone G, Breithardt OA, et al. Echocardiographic evaluation of cardiac resynchronization therapy: Ready for routine clinical use? A critical appraisal. J Am Coll Cardiol 2004;44:1–9.PubMedCrossRefGoogle Scholar
  8. 8.
    Breithardt OA, Stellbrink C, Franke A, et al.; Pacing Therapies for Congestive Heart Failure Study Group; Guidant Congestive Heart Failure Research Group. Acute effects of cardiac resynchronization therapy on left ventricular Doppler indices in patients with congestive heart failure. Am Heart J 2002;143: 34–44.PubMedCrossRefGoogle Scholar
  9. 9.
    Breithardt OA. Conventional echocardiography. In: Yu CM, Hayes DL, Auricchio A, eds. Cardiac Resynchronization Therapy. Malden, MA: Blackwell-Futura; 2006:76–88.Google Scholar
  10. 10.
    Auricchio A, Stellbrink C, Block M, et al. Effect of pacing chamber and atrioventricular delay on acute systolic function of paced patients with congestive heart failure. The Pacing Therapies for Congestive Heart Failure Study Group. The Guidant Congestive Heart Failure Research Group. Circulation 1999;99: 2993–3001.PubMedGoogle Scholar
  11. 11.
    Auricchio A, Ding J, Spinelli JC, et al. Cardiac resynchronization therapy restores optimal atrioventricular mechanical timing in heart failure patients with ventricular conduction delay. J Am Coll Cardiol 2002;39:1163–9.PubMedCrossRefGoogle Scholar
  12. 12.
    Hay I, Melenovsky V, Fetics BJ, et al. Short-term effects of right-left heart sequential cardiac resynchronization in patients with heart failure, chronic atrial fibrillation, and atrioventricular nodal block. Circulation 2004;110:3404–10.PubMedCrossRefGoogle Scholar
  13. 13.
    Perego GB, Chianca R, Facchini M, et al. Simultaneous vs. sequential biventricular pacing in dilated cardiomyopathy: An acute hemodynamic study. Eur J Heart Fail 2003;5:305–13.PubMedCrossRefGoogle Scholar
  14. 14.
    Kurzidim K, Reinke H, Sperzel J, et al. Invasive optimization of cardiac resynchronization therapy: Role of sequential ventricular and left ventricular pacing. Pacing Clin Electrophysiol 2005;28:754–61.PubMedCrossRefGoogle Scholar
  15. 15.
    van Gelder BM, Bracke FA, Meijer A, Lakerveld LJ, Pijls NH. Effect of optimizing the VV interval on left ventricular contractility in cardiac resynchronization therapy. Am J Cardiol 2004;93:1500–3.PubMedCrossRefGoogle Scholar
  16. 16.
    Marcus GM, Rose E, Viloria EM, et al.; VENTAK CHF/CONTAK-CD Biventricular Pacing Study Investigators. Septal to posterior wall motion delay fails to predict reverse remodeling or clinical improvement in patients undergoing cardiac resynchronization therapy. J Am Coll Cardiol 2005;46:2208–14.PubMedCrossRefGoogle Scholar
  17. 17.
    Yu CM, Zhang Q, Chan YS, et al. Tissue doppler velocity is superior to displacement and strain mapping in predicting left ventricular reverse remodeling response after cardiac resynchronization therapy. Heart 2006;92:1452–6.PubMedCrossRefGoogle Scholar
  18. 18.
    Yu CM, Wing-Hong Fung J, Zhang Q, Sanderson JE. Understanding nonresponders of cardiac resynchronization therapy—current and future perspectives. J Cardiovasc Electrophysiol 2005;16:1117–24.PubMedCrossRefGoogle Scholar
  19. 19.
    Delfino JG, Bhasin M, Cole R, Eisner RL, Merlino J, Leon AR, Oshinski JN. Comparison of myocardial velocities obtained with magnetic resonance phase velocity mapping and tissue doppler imaging in normal subjects and patients with left ventricular dyssynchrony. J Magn Reson Imaging 2006;24:304–11.PubMedCrossRefGoogle Scholar
  20. 20.
    Burri H, Lerch R. Echocardiography and patient selection for cardiac resynchronization therapy: A critical appraisal. Heart Rhythm 2006;3:474–9.PubMedCrossRefGoogle Scholar
  21. 21.
    Notabartolo D, Merlino JD, Smith AL, et al. Usefulness of the peak velocity difference by tissue Doppler imaging technique as an effective predictor of response to cardiac resynchronization therapy. Am J Cardiol 2004;94:817–20.PubMedCrossRefGoogle Scholar
  22. 22.
    Ramanathan C, Jia P, Ghanem R, Ryu K, Rudy Y. Activation and repolarization of the 6normal human heart under complete physiological conditions. Proc Natl Acad Sci U S A 2006;103:6309–14.Google Scholar
  23. 23.
    Wyndham CR, Meeran MK, Smith T, et al. Epicardial activation of the intact human heart without conduction defect. Circulation 1979;59:161–8.PubMedGoogle Scholar
  24. 24.
    Nelson GS, Curry CW, Wyman BT, et al. Predictors of systolic augmentation from left ventricular preexcitation in patients with dilated cardiomyopathy and intraventricular conduction delay. Circulation 2000;101:2703–2709.PubMedGoogle Scholar
  25. 25.
    Rodriguez LM, Timmermans C, Nabar A, Beatty G, Wellens HJ. Variable patterns of septal activation in patients with left bundle branch block and heart failure. J Cardiovasc Electrophysiol 2003;14:135–41.PubMedCrossRefGoogle Scholar
  26. 26.
    Fung JW, Yu CM, Yip G, et al. Variable left ventricular activation pattern in patients with heart failure and left bundle branch block. Heart 2004;90:17–9.PubMedCrossRefGoogle Scholar
  27. 27.
    Auricchio A, Fantoni C, Regoli F, et al. Characterization of left ventricular activation in patients with heart failure and left bundle-branch block. Circulation 2004;109:1133–9.PubMedCrossRefGoogle Scholar
  28. 28.
    Herweg B, Ilercil A, Madramootoo C, et al. Latency during left ventricular pacing from the lateral cardiac veins: A cause of ineffectual biventricular pacing. Pacing Clin Electrophysiol 2006;29:574–81.PubMedCrossRefGoogle Scholar
  29. 29.
    Sogaard P, Egeblad H, Pedersen AK, et al. Sequential versus simultaneous biventricular resynchronization for severe heart failure: Evaluation by tissue Doppler imaging. Circulation 2002;106:2078–84.PubMedCrossRefGoogle Scholar
  30. 30.
    Mortensen PT, Sogaard P, Mansour H, et al. Sequential biventricular pacing: evaluation of safety and efficacy. Pacing Clin Electrophysiol 2004;27:339–45.PubMedCrossRefGoogle Scholar
  31. 31.
    Porciani MC, Dondina C, Macioce R, et al. Echocardiographic examination of atrioventricular and interventricular delay optimization in cardiac resynchronization therapy. Am J Cardiol 2005;95:1108–10.PubMedCrossRefGoogle Scholar
  32. 32.
    Riedlbauchova L, Kautzner J, Fridl P. Influence of different atrioventricular and interventricular delays on cardiac output during cardiac resynchronization therapy. Pacing Clin Electrophysiol 2005;28(Suppl 1):S19–23.PubMedCrossRefGoogle Scholar
  33. 33.
    Vanderheyden M, De Backer T, Rivero-Ayerza M, et al. Tailored echocardiographic interventricular delay programming further optimizes left ventricular performance after cardiac resynchronization therapy. Heart Rhythm 2005;2: 1066–72.PubMedCrossRefGoogle Scholar
  34. 34.
    Leon AR, Abraham WT, Brozena S, et al.; InSync III Clinical Study Investigators. Cardiac resynchronization with sequential biventricular pacing for the treatment of moderate-to-severe heart failure. J Am Coll Cardiol 2005;46:2298–304.PubMedCrossRefGoogle Scholar
  35. 35.
    Bordachar P, Lafitte S, Reuter S, et al.. Echocardiographic parameters of ventricular dyssynchrony validation in patients with heart failure using sequential biventricular pacing. J Am Coll Cardiol 2004;44:2157–65.PubMedCrossRefGoogle Scholar
  36. 36.
    Boriani G, Muller CP, Seidl KH, et al.; Resynchronization for the HemodYnamic Treatment for Heart Failure Management II Investigators. Randomized comparison of simultaneous biventricular stimulation versus optimized interventricular delay in cardiac resynchronization therapy. The Resynchronization for the HemodYnamic Treatment for Heart Failure Management II implantable cardioverter defibrillator (RHYTHM II ICD) study. Am Heart J 2006;151:1050–8.PubMedCrossRefGoogle Scholar
  37. 37.
    Bordachar P, Lafitte S, Reuter S, et al. Echocardiographic assessment during exercise of heart failure patients with cardiac resynchronization therapy. Am J Cardiol 2006;97:1622–5.PubMedCrossRefGoogle Scholar
  38. 38.
    Kay GN. Troubleshooting and programming of cardiac resynchronization therapy. In: Ellenbogen KA, Kay GN, Wilkoff BL, eds. Device Therapy for Congestive Heart Failure. Philadelphia: Saunders; 2004:232–93.Google Scholar
  39. 39.
    O’Donnell D, Nadurata V, Hamer A, Kertes P, Mohammed W. Long-term variations in optimal programming of cardiac resynchronization therapy devices. Pacing Clin Electrophysiol 2005;28(Suppl 1):S24–6.PubMedCrossRefGoogle Scholar
  40. 40.
    van Gelder BM, Bracke FA, Meijer A. The effect of anodal stimulation on V-V timing at varying V-V intervals. Pacing Clin Electrophysiol 2005;28:771–6.PubMedCrossRefGoogle Scholar
  41. 41.
    Tamborero D, Mont L, Alanis R, et al. Anodal capture in cardiac resynchronization therapy. Implications for device programming. Pacing Clin Electrophysiol 2006;29:940–5.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • S. Serge Barold
  • Arzu Ilercil
  • Bengt Herweg

There are no affiliations available

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