Significance of Latency During Left Ventricular Pacing for Cardiac Resynchronization Therapy

  • Bengt Herweg
  • Arzu Ilercil
  • Chris Madramootoo
  • Nadim G. Khan
  • S. Serge Barold


Right Ventricular Cardiac Resynchronization Therapy Biventricular Pace Leave Ventricular Lead Latency Interval 
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  1. 1.
    A Bax JJ, Bleeker GB, Marwick TH, et al. Left ventricular dyssynchrony predicts response and prognosis after cardiac resynchronization therapy. J Am Coll Cardiol 2004;44:1834–40.CrossRefGoogle Scholar
  2. 2.
    Abraham WT, Fisher WG, Smith AL, et al.; MIRACLE Study Group. Multicenter InSync Randomized Clinical Evaluation. Cardiac resynchronization in chronic heart failure. N Engl J Med 2002;346:1845–53.PubMedCrossRefGoogle Scholar
  3. 3.
    Abraham WT. Cardiac resynchronization therapy: A review of clinical trials and criteria for identifying the appropriate patient. Rev Cardiovasc Med 2003;4(Suppl 2):S30–7.Google Scholar
  4. 4.
    Yu CM, Wing-Hong Fung J, Zhang Q, Sanderson JE. Understanding nonresponders of cardiac resynchronization therapy–current and future perspectives. J Cardiovasc Electrophysiol 2005;16:1117–24.PubMedCrossRefGoogle Scholar
  5. 5.
    Doshi RN. Optimizing resynchronization therapy: can we increase the number of true responders? J Cardiovasc Electrophysiol 2005;16(Suppl 1):S48–51.PubMedCrossRefGoogle Scholar
  6. 6.
    Rosanio S, Schwarz ER, Ahmad M, et al. Benefits, unresolved questions, and technical issues of cardiac resynchronization therapy for heart failure. Am J Cardiol 2005;96:710–7.PubMedCrossRefGoogle Scholar
  7. 7.
    Herweg B, Ilercil A, Madramootoo C, et al. Latency during left ventricular pacing from the lateral cardiac veins: A cause of ineffectual biventricular pacing. Pacing Clin Electrophysiol 2006;29:574–81.PubMedCrossRefGoogle Scholar
  8. 8.
    Rodriguez LM, Timmermans C, Nabar A, Beatty G, Wellens HJ. Variable patterns of septal activation in patients with left bundle branch block and heart failure. J Cardiovasc Electrophysiol 2003;14:135–41.PubMedCrossRefGoogle Scholar
  9. 9.
    Fung JW, Yu CM, Yip G, et al. Variable left ventricular activation pattern in patients with heart failure and left bundle branch block. Heart 2004;90:17–9.PubMedCrossRefGoogle Scholar
  10. 10.
    Auricchio A, Fantoni C, Regoli F, et al. Characterization of left ventricular activation in patients with heart failure and left bundle-branch block. Circulation 2004;109:1133–9PubMedCrossRefGoogle Scholar
  11. 11.
    Moss AJ, Goldstein S. Clinical and pharmacological factors associated with pacemaker latency and incomplete pacemaker capture. Br Heart J 1969;31:112–17.PubMedCrossRefGoogle Scholar
  12. 12.
    Kistler PM, Mond HG, Vohra JK. Pacemaker ventricular block. Pacing Clin Electrophysiol 2003;26:1997–99.PubMedCrossRefGoogle Scholar
  13. 13.
    Barold SS, Falkoff MD, Ong LS, Heinle RA. Normal and abnormal patterns of ventricular depolarization during cardiac pacing. In Barold SS, ed. Modern Cardiac Pacing. Mt Kisco, NY: Futura; 1985:545–69.Google Scholar
  14. 14.
    Varriale P, Manolis A. Pacemaker Wenckebach secondary to variable latency: an unusual form of hyperkalemic pacemaker exit block. Am Heart J 1987;114: 189–92.PubMedCrossRefGoogle Scholar
  15. 15.
    Bashour TT. Spectrum of ventricular pacemaker exit block owing to hyperkalemia. Am J Cardiol 1986;57:337–38.PubMedCrossRefGoogle Scholar
  16. 16.
    Klein HO, Di Segni E, Kaplinsky E, Schamroth L. The Wenckebach phenomenon between electric pacemaker and ventricle. Br Heart J 1976;38:961–7.PubMedCrossRefGoogle Scholar
  17. 17.
    Peter T, Harper R, Hunt D, Sloman G. Wenckebach phenomenon in the exit area from transvenous pacing electrode. Br Heart J 1976;38:201–3.PubMedCrossRefGoogle Scholar
  18. 18.
    van Gelder BM, Bracke FA, Meijer A, Lakerveld LJ, Pijls NH. Effect of optimizing the VV interval on left ventricular contractility in cardiac resynchronization therapy. Am J Cardiol 2004;93:1500–1503.PubMedCrossRefGoogle Scholar
  19. 19.
    Perego GB, Chianca R, Facchini M, et al. Simultaneous vs. sequential biventricular pacing in dilated cardiomyopathy: an acute hemodynamic study. Eur J Heart Fail 2003;5:305–13.PubMedCrossRefGoogle Scholar
  20. 20.
    Sogaard P, Egeblad H, Pedersen AK, et al. Sequential versus simultaneous biventricular resynchronization for severe heart failure: evaluation by tissue Doppler imaging. Circulation 2002;106:2078–84.PubMedCrossRefGoogle Scholar
  21. 21.
    Vanderheyden M, De Backer T, Rivero-Ayerza M, et al. Tailored echocardiographic interventricular delay programming further optimize left ventricular performance after cardiac resynchronization therapy. Heart Rhythm 2005;2: 1066–72.PubMedCrossRefGoogle Scholar
  22. 22.
    Riedlbauchova L, Kautzner J, Fridl P. Influence of different atrioventricular and interventricular delays on cardiac output during cardiac resynchronization therapy. Pacing Clin Electrophysiol 2005;28:S19–23.PubMedCrossRefGoogle Scholar
  23. 23.
    Bordachar P, Lafitte S, Reuter S, et al. Echocardiographic parameters of ventricular dyssynchrony validation in patients with heart failure using sequential biventricular pacing. J Am Coll Cardiol 2004;44:2157–65.PubMedCrossRefGoogle Scholar
  24. 24.
    Burri H, Sunthorn H, Somsen A, et al. Optimizing sequential biventricular pacing using radionuclide ventriculography. Heart Rhythm 2005;2:960–5.PubMedCrossRefGoogle Scholar
  25. 25.
    Mortensen PT, Sogaard P, Mansour H, et al. Sequential biventricular pacing: evaluation of safety and efficacy. Pacing Clin Electrophysiol 2004;27:339–45.PubMedCrossRefGoogle Scholar
  26. 26.
    Kurzidim K, Reinke H, Sperzel J, et al. Invasive optimization of cardiac resynchronization therapy: role of sequential biventricular and left ventricular pacing. Pacing Clin Electrophysiol 2005;28:754–61.PubMedCrossRefGoogle Scholar
  27. 27.
    Porciani MC, Dondina C, Macioce R, et al. Echocardiographic examination of atrioventricular and interventricular delay optimization in cardiac resynchronization therapy. Am J Cardiol 2005;95:1108–10.PubMedCrossRefGoogle Scholar
  28. 28.
    Barold SS, Herweg B, Giudici M. Electrocardiographic follow-up of biventricular pacemakers. Ann Noninvasive Electrocardiol 2005;10:231–55.PubMedCrossRefGoogle Scholar
  29. 29.
    Barold SS, Giudici M, Herweg B, Curtis AB. Diagnostic value of the 12-lead electrocardiogram during conventional and biventricular pacing for cardiac resynchronization. Cardiol Clin 2006;24:471–90.PubMedCrossRefGoogle Scholar
  30. 30.
    Bleeker GB, Kaandorp TA, Lamb HJ, et al. Effect of posterolateral scar tissue on clinical and echocardiographic improvement after cardiac resynchronization therapy. Circulation 2006;113(7):926–8.CrossRefGoogle Scholar
  31. 31.
    Bleeker GB, Schalij MJ, Van Der Wall EE, Bax JJ. Postero-lateral scar tissue resulting in non-response to cardiac resynchronization therapy. J Cardiovasc Electrophysiol 2006;17(8):899–901.PubMedCrossRefGoogle Scholar
  32. 32.
    Arzola-Castaner D, Taub C, Kevin Heist E, et al. Left ventricular lead proximity to an akinetic segment and impact on outcome of cardiac resynchronization therapy. J Cardiovasc Electrophysiol. 2006;17(6):623–7.PubMedCrossRefGoogle Scholar
  33. 33.
    Herweg B, Barold SS. Anodal capture with second-generation biventricular cardioverter-defibrillator. Acta Cardiol 2003;58:435–6.PubMedCrossRefGoogle Scholar
  34. 34.
    Thibault B, Roy D, Guerra PG, et al. Anodal right ventricular capture during left ventricular stimulation in CRT-implantable cardioverter defibrillators. Pacing Clin Electrophysiol 2005;28:613–19.PubMedCrossRefGoogle Scholar
  35. 35.
    van Gelder BM, Bracke FA, Meijer A. The effect of anodal stimulation on V-V timing at varying V-V intervals. Pacing Clin Electrophysiol 2005;28:771–6.PubMedCrossRefGoogle Scholar
  36. 36.
    Tedrow U, Maisel WH, Epstein LM, Soejima K, Stevenson WG. Feasibility of adjusting paced left ventricular activation by manipulating stimulus strength. J Am Coll Cardiol 2004;44(11):2247–52.CrossRefGoogle Scholar
  37. 37.
    Sauer WH, Sussman JS, Verdino RJ, Cooper JM. Increasing left ventricular pacing output decreases interventricular conduction time in patients with biventricular pacing systems. Pacing Clin Electrophysiol 2006;29(6):569–73.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Bengt Herweg
  • Arzu Ilercil
  • Chris Madramootoo
  • Nadim G. Khan
  • S. Serge Barold

There are no affiliations available

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