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Stereotactic Body Radiation Therapy: Brachytherapy Perspective

  • Caroline L. Holloway
  • Desmond O’Farrell
  • Phillip M. Devlin

Abstract

Brachytherapy was conceptualized in the early 1900s when Pierre Curie suggested that a small radium tube could be inserted directly into cancer. Experiments carried out at that time showed tumor shrinkage in response to the directed radiation. The first therapeutic brachytherapy treatments used surface molds to deliver low dose rate (LDR) radiation to skin cancers, and by 1903 the first intracavitary radium treatment for cervical cancer was delivered. The use of brachytherapy waned over the 20th century with the advent of external beam radiation therapy and the development of the linear accelerator. However, brachytherapy continued to be integral in the treatment of many Gynecologic cancers. Developments in image guidance, high dose rate (HDR) and pulsed dose rate (PDR) after-loading machines, and the ability to computer-optimize treatments have again made brachytherapy a prominent component of radiation oncology departments. Brachytherapy is used for curative-intent treatments in sarcomas, Gynecologic, prostate, and head and neck malignancies, partial breast irradiation, and can be used with surface applicators for skin cancer. It is also part of the management of cancer in the lung in both curative and palliative settings. Brachytherapy can also be used in the palliative setting in rectal, esophageal, and hepatobiliary cancers.

Keywords

External Beam Radiation Therapy Radiat Oncol Biol Phys Stereotactic Body Radiation Therapy High Dose Rate Radiation Pneumonitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Kim TH, Cho KH, Pyo HR, et al. Dose-volumetric parameters for predicting severe radiation pneumonitis after three-dimensional conformal radiation therapy for lung cancer. Radiology 2005; 235:208–215.CrossRefPubMedGoogle Scholar
  2. 2.
    Yorke ED, Jackson A, Rosenzweig KE, et al. Correlation of dosimetric factors and radiation pneumonitis for non-small-cell lung cancer patients in a recently completed dose escalation study. Int J Radiat Oncol Biol Phys 2005; 63:672–682.PubMedGoogle Scholar
  3. 3.
    Voynov G, Heron DE, Lin CJ, et al. Intraoperative 125I Vicryl mesh brachytherapy after sublobar resection for high-risk stage I nonsmall cell lung cancer. Brachytherapy 2005; 4:278.CrossRefPubMedGoogle Scholar
  4. 4.
    Mutyala S, Stewart AJ, Cormack R, et al. Toxicity of permanent I-125 interstitial planar seed brachytherapy for close or positive margins for thoracic malignancies. Int J Radiat Oncol Biol Phys 2005; 63:S392–S393.Google Scholar
  5. 5.
    Chen A, Galloway M, Landreneau R, et al. Intraoperative 125I brachytherapy for high-risk stage I non-small cell lung carcinoma. [see comment]. Int J Radiat Oncol Biol Phys 1999; 44:1057–1063.PubMedGoogle Scholar
  6. 6.
    Raben A, Mychalczak B. Brachytherapy for non-small cell lung cancer and selected neoplasms of the chest. Chest 1997; 112(4 Suppl):2765–2865.CrossRefGoogle Scholar
  7. 7.
    Stewart AJ, O’Farrell DA, Mutyala S, et al. Severe toxicity after permanent radioactive seed implantation for mediastinal carcinoid tumor. Brachytherapy 2007; 6(1):58–61.CrossRefPubMedGoogle Scholar
  8. 8.
    Kelly JF, Delclos ME, Morice RC, et al. High-dose-rate endobronchial brachytherapy effectively palliates symptoms due to airway tumors: the 10-year M. D. Anderson cancer center experience. Int J Radiat Oncol Biol Phys 2000; 48:697–702.PubMedGoogle Scholar
  9. 9.
    Nag S, Kelly JF, Horton JL, et al. Brachytherapy for carcinoma of the lung. Oncology 2001; 15:371–381.PubMedGoogle Scholar
  10. 10.
    Deodato F, Clemente G, Mattiucci GC, et al. Chemoradiation and brachytherapy in biliary tract carcinoma: Long-term results. Int J Radiat Oncol Biol Phys 2006; 64:483–488.PubMedGoogle Scholar
  11. 11.
    Kennedy AS, Nutting C, Coldwell D, et al. Pathologic response and microdosimetry of (90)Y microspheres in man: review of four explanted whole livers. Int J Radiat Oncol Biol Phys 2004; 60:1552–1563.PubMedGoogle Scholar
  12. 12.
    Stubbs RS, Cannan RJ, Mitchell AW. Selective internal radiation therapy with 90yttrium microspheres for extensive colorectal liver metastases. J Gastrointest Surg 2001; 5:294–302.CrossRefPubMedGoogle Scholar
  13. 13.
    Van Hazel G, Blackwell A, Anderson J, et al. Randomised phase 2 trial of SIR-Spheres plus fluorouracil/leucovorin chemotherapy versus fluorouracil/leucovorin chemotherapy alone in advanced colorectal cancer. J Surg Oncol 2004; 88:78–85.CrossRefPubMedGoogle Scholar
  14. 14.
    Lambert B, Van de Wiele C. Treatment of hepatocellular carcinoma by means of radiopharmaceuticals. Eur J Nucl Med Mol Imaging 2005; 32:980–989.CrossRefPubMedGoogle Scholar
  15. 15.
    Schuricht AL, Spitz F, Barbot D, et al. Intraoperative radiotherapy in the combined-modality management of pancreatic cancer. Am Surg 1998; 64:1043–1049.PubMedGoogle Scholar
  16. 16.
    Pfreundner L, Baier K, Schwab F, et al. [3D-Ct-planned interstitial HDR brachytherapy + percutaneous irradiation and chemotherapy in inoperable pancreatic carcinoma. Methods and clinical outcome]. Strahlenther Onkol 1998; 174:133–141.CrossRefPubMedGoogle Scholar
  17. 17.
    Zhang K, Loong SL, Connor S, et al. Complete tumor response following intratumoral 32P BioSilicon on human hepatocellular and pancreatic carcinoma xenografts in nude mice. Clin Cancer Res 2005; 11:7532–7537.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Caroline L. Holloway
    • 1
  • Desmond O’Farrell
    • 2
  • Phillip M. Devlin
    • 3
    • 4
  1. 1.Department of Radiation OncologyBCCA—Centre for the Southern InteriorKelownaCanada
  2. 2.Division of Brachytherapy, Department of Radiation OncologyDana Farber/Brigham & Women’s HospitalBostonUSA
  3. 3.Department of Radiation OncologyHarvard Medical SchoolUSA
  4. 4.Department of Radiation OncologyDana Farber/Brigham & Women’s HospitalBostonUSA

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