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Experimental Radiosurgery Models

  • Ajay Niranjan
  • Douglas Kondziolka

Abstract

The field of stereotactic radiosurgery represents one of the fundamental shifts in neurologic surgery over the past two decades. Compared with conventional invasive surgery techniques, radiosurgery is minimally invasive and relies on biological response of tissues in order to eradicate or inactivate them. Radiosurgery is conceptually different from fractionated radiation therapy. The efficacy of large-field fractionated radiotherapy to treat brain tumors is dependent on biological differences between normal and tumor cells. Fractionated radiotherapy exploits these differences to limit the risk of normal tissue injury in patients with malignant brain tumors, thus it can increase the therapeutic ratio, which is equivalent to the rate of tumor control divided by the rate of complications.

Keywords

Trigeminal Neuralgia Gamma Knife Stereotactic Radiosurgery Malignant Brain Tumor Suicide Gene Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Ajay Niranjan
    • 1
  • Douglas Kondziolka
    • 1
  1. 1.University of PittsburghPittsburghUSA

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